2024
Genomic surveillance of malaria parasites in an indigenous community in the Peruvian Amazon
Cabrera-Sosa L, Nolasco O, Kattenberg J, Fernandez-Miñope C, Valdivia H, Barazorda K, Arévalo de los Rios S, Rodriguez-Ferrucci H, Vinetz J, Rosanas-Urgell A, Van geertruyden J, Gamboa D, Delgado-Ratto C. Genomic surveillance of malaria parasites in an indigenous community in the Peruvian Amazon. Scientific Reports 2024, 14: 16291. PMID: 39009685, PMCID: PMC11250820, DOI: 10.1038/s41598-024-66925-x.Peer-Reviewed Original ResearchConceptsPassive case detectionPf parasitesPersistent malaria transmissionPfhrp2/3 gene deletionsDeep sequencing assaySulfadoxine-pyrimethamineMalaria casesMalaria eliminationPlasmodium vivaxMalaria parasitesMalaria transmissionP. falciparumResistance mutationsImported infectionsMalariaPopulation genetic indicesSequencing assayCase detectionGene deletionPV populationResistance markersGenetic diversityPeruvian AmazonGenomic surveillanceGenetic indices
2022
Geographical distribution and genetic characterization of pfhrp2 negative Plasmodium falciparum parasites in the Peruvian Amazon
Bendezu J, Torres K, Villasis E, Incardona S, Bell D, Vinetz J, Gamboa D. Geographical distribution and genetic characterization of pfhrp2 negative Plasmodium falciparum parasites in the Peruvian Amazon. PLOS ONE 2022, 17: e0273872. PMID: 36413547, PMCID: PMC9681099, DOI: 10.1371/journal.pone.0273872.Peer-Reviewed Original Research
2010
Apical Surface Expression of Aspartic Protease Plasmepsin 4, a Potential Transmission-blocking Target of the Plasmodium Ookinete*
Li F, Patra KP, Yowell CA, Dame JB, Chin K, Vinetz JM. Apical Surface Expression of Aspartic Protease Plasmepsin 4, a Potential Transmission-blocking Target of the Plasmodium Ookinete*. Journal Of Biological Chemistry 2010, 285: 8076-8083. PMID: 20056606, PMCID: PMC2832958, DOI: 10.1074/jbc.m109.063388.Peer-Reviewed Original ResearchConceptsPlasmepsin 4Midgut invasionAspartic proteasesDigestive vacuoleMidgut peritrophic matrixApical surface expressionChitin-binding proteinsMass spectrometry sequencingMalaria parasitesPeritrophic matrixPlasmodium invasionAspartic protease inhibitorsPlasmodium ookinetesParasite infectivityApical surfaceDefinitive hostsMechanistic roleAffinity columnBlood-stage PlasmodiumSurface expressionCalpain inhibitorsMidgut basal laminaProteinVaccine targetsVacuoles
1989
Interdependence of CD4+ T cells and malarial spleen in immunity to Plasmodium vinckei vinckei. Relevance to vaccine development.
Kumar S, Good M, Dontfraid F, Vinetz J, Miller L. Interdependence of CD4+ T cells and malarial spleen in immunity to Plasmodium vinckei vinckei. Relevance to vaccine development. The Journal Of Immunology 1989, 143: 2017-23. PMID: 2570802, DOI: 10.4049/jimmunol.143.6.2017.Peer-Reviewed Original ResearchConceptsBALB/c micePlasmodium vinckei vinckeiT cellsImmune miceC miceVivo depletionSpleen cellsNaive BALB/cAthymic nu/nu miceBALB/c nude miceC3H/HeN miceNu/nu miceImmune spleen cellsBALB/cLoss of immunityImmune CD4Malaria AgMalarial spleenVivo CD4Adoptive transferImmune spleenSplenectomized miceMalaria vaccineRodent malariaHeN mice