2019
Modulators of Kv3 Potassium Channels Rescue the Auditory Function of Fragile X Mice
El-Hassar L, Song L, Tan WJT, Large CH, Alvaro G, Santos-Sacchi J, Kaczmarek LK. Modulators of Kv3 Potassium Channels Rescue the Auditory Function of Fragile X Mice. Journal Of Neuroscience 2019, 39: 4797-4813. PMID: 30936239, PMCID: PMC6561694, DOI: 10.1523/jneurosci.0839-18.2019.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAuditory PathwaysAuditory PerceptionBrain StemCochlear NucleusElectrophysiological PhenomenaEvoked Potentials, Auditory, Brain StemFemaleFragile X Mental Retardation ProteinFragile X SyndromeHydantoinsIn Vitro TechniquesMaleMiceMice, KnockoutPatch-Clamp TechniquesPyridinesShaw Potassium ChannelsConceptsAuditory brainstem responseWild-type animalsRepetitive firingABR wave ICurrent-clamp recordingsAuditory brainstem nucleiVoltage-clamp recordingsHigh-frequency firingSingle action potentialFragile X syndromeTrapezoid bodyBrainstem nucleiBrainstem responseMedial nucleusAuditory brainstemAuditory nerveWave IWave IVAction potentialsSensory stimuliKv3.1 channelsCentral processingMental retardation proteinHigh sound levelsMice
2006
On the temperature and tension dependence of the outer hair cell lateral membrane conductance GmetL and its relation to prestin
Santos-Sacchi J, Rybalchenko V, Bai JP, Song L, Navaratnam D. On the temperature and tension dependence of the outer hair cell lateral membrane conductance GmetL and its relation to prestin. Pflügers Archiv - European Journal Of Physiology 2006, 452: 283. PMID: 16521020, DOI: 10.1007/s00424-005-0037-2.Peer-Reviewed Original Research
2002
Voltage-dependent changes in specific membrane capacitance caused by prestin, the outer hair cell lateral membrane motor
Santos-Sacchi J, Navarrete E. Voltage-dependent changes in specific membrane capacitance caused by prestin, the outer hair cell lateral membrane motor. Pflügers Archiv - European Journal Of Physiology 2002, 444: 99-106. PMID: 11976921, DOI: 10.1007/s00424-002-0804-2.Peer-Reviewed Original ResearchConceptsMembrane motorHEK cellsOuter hair cellsArea motor modelLateral membrane areaLateral plasma membranePlasma membraneProtein prestinConstant membrane thicknessConformational changesCharge movementMembrane capacitanceMolecular motorsPrestinMembrane surface areaVoltage sensorDeiters' cellsHair cellsCellsExtreme hyperpolarizationMembrane voltageVoltage-dependent changesMembrane area
2001
Furosemide alters nonlinear capacitance in isolated outer hair cells
Santos-Sacchi J, Wu M, Kakehata S. Furosemide alters nonlinear capacitance in isolated outer hair cells. Hearing Research 2001, 159: 69-73. PMID: 11520635, DOI: 10.1016/s0378-5955(01)00321-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDiureticsElectric CapacitanceFeedbackFurosemideGuinea PigsHair Cells, Auditory, OuterIn Vitro TechniquesMovementPatch-Clamp TechniquesConceptsOuter hair cellsWhole-cell patch-clamp techniqueHair cellsNormal cochlear functionIsolated outer hair cellsPatch-clamp techniqueOrgan of CortiLoop diureticsSensory dysfunctionHearing resultsCochlear functionEndolymphatic potentialFurosemideDirect effectHill coefficientPositive levelCellsDiureticsDysfunctionPresent results
1999
Auditory collusion and a coupled couple of outer hair cells
Zhao H, Santos-Sacchi J. Auditory collusion and a coupled couple of outer hair cells. Nature 1999, 399: 359-362. PMID: 10360573, DOI: 10.1038/20686.Peer-Reviewed Original Research
1998
Density of motility-related charge in the outer hair cell of the guinea pig is inversely related to best frequency
Santos-Sacchi J, Kakehata S, Kikuchi T, Katori Y, Takasaka T. Density of motility-related charge in the outer hair cell of the guinea pig is inversely related to best frequency. Neuroscience Letters 1998, 256: 155-158. PMID: 9855363, DOI: 10.1016/s0304-3940(98)00788-5.Peer-Reviewed Original ResearchTemperature dependence of outer hair cell nonlinear capacitance
Santos-Sacchi J, Huang G. Temperature dependence of outer hair cell nonlinear capacitance. Hearing Research 1998, 116: 99-106. PMID: 9508032, DOI: 10.1016/s0378-5955(97)00204-9.Peer-Reviewed Original Research
1997
Mapping the distribution of outer hair cell voltage-dependent conductances by electrical amputation
Santos-Sacchi J, Huang GJ, Wu M. Mapping the distribution of outer hair cell voltage-dependent conductances by electrical amputation. Biophysical Journal 1997, 73: 1424-1429. PMID: 9284309, PMCID: PMC1181041, DOI: 10.1016/s0006-3495(97)78174-8.Peer-Reviewed Original ResearchConceptsLateral membranesVoltage magnitudeElectrical techniquesAcoustic frequencyKilohertz rangeOuter hair cell functionVoltage-dependent conductancesVoltage sensorPlasma membraneHair cell functionMechanical effectorsSynaptic poleVoltage-dependent currentsMembrane moleculesAuditory functionDense populationCell functionCable propertiesCochlear amplifierOHC motilitySensory receptors
1994
Motility voltage sensor of the outer hair cell resides within the lateral plasma membrane.
Huang G, Santos-Sacchi J. Motility voltage sensor of the outer hair cell resides within the lateral plasma membrane. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 12268-12272. PMID: 7991617, PMCID: PMC45418, DOI: 10.1073/pnas.91.25.12268.Peer-Reviewed Original Research
1993
Harmonics of outer hair cell motility
Santos-Sacchi J. Harmonics of outer hair cell motility. Biophysical Journal 1993, 65: 2217-2227. PMID: 8298045, PMCID: PMC1225953, DOI: 10.1016/s0006-3495(93)81247-5.Peer-Reviewed Original ResearchMapping the distribution of the outer hair cell motility voltage sensor by electrical amputation
Huang G, Santos-Sacchi J. Mapping the distribution of the outer hair cell motility voltage sensor by electrical amputation. Biophysical Journal 1993, 65: 2228-2236. PMID: 8298046, PMCID: PMC1225954, DOI: 10.1016/s0006-3495(93)81248-7.Peer-Reviewed Original Research
1985
The effects of cytoplasmic acidification upon electrical coupling in the organ of Corti
Santos-Sacchi J. The effects of cytoplasmic acidification upon electrical coupling in the organ of Corti. Hearing Research 1985, 19: 207-215. PMID: 3934121, DOI: 10.1016/0378-5955(85)90140-6.Peer-Reviewed Original Research
1984
A re-evaluation of cell coupling in the organ of Corti
Santos-Sacchi J. A re-evaluation of cell coupling in the organ of Corti. Hearing Research 1984, 14: 203-204. PMID: 6746433, DOI: 10.1016/0378-5955(84)90019-4.Peer-Reviewed Original Research
1983
Intercellular communication in the supporting cells of the organ of Corti
Santos-Sacchi J, Dallos P. Intercellular communication in the supporting cells of the organ of Corti. Hearing Research 1983, 9: 317-326. PMID: 6841286, DOI: 10.1016/0378-5955(83)90034-5.Peer-Reviewed Original Research