2021
Efferent feedback controls bilateral auditory spontaneous activity
Wang Y, Sanghvi M, Gribizis A, Zhang Y, Song L, Morley B, Barson DG, Santos-Sacchi J, Navaratnam D, Crair M. Efferent feedback controls bilateral auditory spontaneous activity. Nature Communications 2021, 12: 2449. PMID: 33907194, PMCID: PMC8079389, DOI: 10.1038/s41467-021-22796-8.Peer-Reviewed Original ResearchConceptsSpontaneous activityEfferent modulationEfferent pathwaysMedial olivocochlear systemCentral nervous systemCentral auditory systemInner hair cellsAuditory systemNicotinic acetylcholine receptorsSpontaneous activity patternsOlivocochlear systemHearing onsetEfferent systemChemogenetic experimentsBilateral couplingNervous systemAcetylcholine receptorsCircuit formationEfferent feedbackFiring patternsHair cellsΑ9/Auditory sensitivityBilateral correlationActivity patterns
1993
Voltage-dependent ionic conductances of type I spiral ganglion cells from the guinea pig inner ear
Santos-Sacchi J. Voltage-dependent ionic conductances of type I spiral ganglion cells from the guinea pig inner ear. Journal Of Neuroscience 1993, 13: 3599-3611. PMID: 8393487, PMCID: PMC6576533, DOI: 10.1523/jneurosci.13-08-03599.1993.Peer-Reviewed Original ResearchConceptsType I spiral ganglion cellsSpiral ganglion cellsOutward K currentsGuinea pig inner earGanglion cellsK currentsSpiral ganglion cell somataTTX-sensitive Na currentsInner earGanglion cell somataSpontaneous spike activityWhole-cell voltage clampNa currentIntrinsic membrane propertiesInner hair cellsSingle-unit studiesSingle-unit activityHalf-maximal amplitudeAfferent innervationCochlear nucleusIntrinsic electrical propertiesVoltage-dependent ionic conductancesCell somataExtracellular ionic environmentSpike activity
1982
Intracellular Recordings from Cochlear Outer Hair Cells
Dallos P, Santos-Sacchi J, Flock Å. Intracellular Recordings from Cochlear Outer Hair Cells. Science 1982, 218: 582-584. PMID: 7123260, DOI: 10.1126/science.7123260.Peer-Reviewed Original Research