2020
Complex nonlinear capacitance in outer hair cell macro-patches: effects of membrane tension
Santos-Sacchi J, Tan W. Complex nonlinear capacitance in outer hair cell macro-patches: effects of membrane tension. Scientific Reports 2020, 10: 6222. PMID: 32277153, PMCID: PMC7148382, DOI: 10.1038/s41598-020-63201-6.Peer-Reviewed Original Research
2018
The Frequency Response of Outer Hair Cell Voltage-Dependent Motility Is Limited by Kinetics of Prestin
Santos-Sacchi J, Tan W. The Frequency Response of Outer Hair Cell Voltage-Dependent Motility Is Limited by Kinetics of Prestin. Journal Of Neuroscience 2018, 38: 5495-5506. PMID: 29899032, PMCID: PMC6001036, DOI: 10.1523/jneurosci.0425-18.2018.Peer-Reviewed Original ResearchConceptsFrequency responseVoltage excitationNonlinear capacitanceFlat frequency responseLow-pass behaviorInterrogation frequencyMechanical responsePiezoelectric couplingCutoff frequencyLow-pass characteristicsLow passElectrical signatureLimiting timeOrders of magnitudeAmplification gainCochlear amplificationKHzΜsMembrane protein prestinVoltageKineticsCapacitanceDamage resultsPhase correspondsElectrical
2011
Membrane-bound voltage sensor-motor elements contrl OHC length
Kakehata S, Santos-Sacchi J, Takasaka T. Membrane-bound voltage sensor-motor elements contrl OHC length. Otology Japan 2011, 7: 92-96. DOI: 10.11289/otoljpn1991.7.92.Peer-Reviewed Original Research
1995
Membrane tension directly shifts voltage dependence of outer hair cell motility and associated gating charge
Kakehata S, Santos-Sacchi J. Membrane tension directly shifts voltage dependence of outer hair cell motility and associated gating charge. Biophysical Journal 1995, 68: 2190-2197. PMID: 7612863, PMCID: PMC1282124, DOI: 10.1016/s0006-3495(95)80401-7.Peer-Reviewed Original ResearchConceptsIntracellular turgor pressureCortical cytoskeletal networkIntracellular pressureOuter hair cellsCytoskeletal networkCell motilityMammalian basilar membraneCytoskeletal elementsTurgor pressureOHC motorMembrane tensionCell collapseMechanical vibrationNonlinear capacitanceVoltage-dependent capacitanceHair cell motilityGating chargeHair cellsCell configurationCapacitanceMembrane stressOuter hair cell motilityWhole-cell voltage-clamp configurationMotility