2017
Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells
Bosurgi L, Cao YG, Cabeza-Cabrerizo M, Tucci A, Hughes LD, Kong Y, Weinstein JS, Licona-Limon P, Schmid ET, Pelorosso F, Gagliani N, Craft JE, Flavell RA, Ghosh S, Rothlin CV. Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells. Science 2017, 356: 1072-1076. PMID: 28495875, PMCID: PMC5556699, DOI: 10.1126/science.aai8132.Peer-Reviewed Original ResearchConceptsApoptotic cellsTissue repair programChemotaxis genesTissue-resident macrophagesIL-4IL-13Tissue repairPattern recognition receptorsTissue repair genesCell adhesionRepair genesGenetic ablationCytokine-dependent inductionHelminth infectionsRecognition receptorsInduction of colitisGenesBroad repertoireSoluble cytokinesMacrophage functionCellsInductionHost responseEctopic activityInterleukin-4
2008
Editing Antigen Presentation: Antigen Transfer between Human B Lymphocytes and Macrophages Mediated by Class A Scavenger Receptors
Harvey BP, Quan TE, Rudenga BJ, Roman RM, Craft J, Mamula MJ. Editing Antigen Presentation: Antigen Transfer between Human B Lymphocytes and Macrophages Mediated by Class A Scavenger Receptors. The Journal Of Immunology 2008, 181: 4043-4051. PMID: 18768860, PMCID: PMC2701691, DOI: 10.4049/jimmunol.181.6.4043.Peer-Reviewed Original ResearchConceptsHuman B lymphocytesB lymphocytesImmune responseB cellsB cell-directed therapiesChronic autoimmune responseCell-directed therapiesScavenger receptor ASpecific B cellsClass A Scavenger ReceptorB cell APCDendritic cellsAntigen transferAutoimmune responseProfessional APCsEfficient APCsAntigen presentationTransfer of AgSpecific AgReceptor AScavenger receptorsMacrophagesLymphocytesAPCReceptors