2006
Abrogation of skin disease in LUPUS‐prone MRL/FASlpr mice by means of a novel tylophorine analog
Choi J, Gao W, Odegard J, Shiah H, Kashgarian M, McNiff JM, Baker DC, Cheng Y, Craft J. Abrogation of skin disease in LUPUS‐prone MRL/FASlpr mice by means of a novel tylophorine analog. Arthritis & Rheumatism 2006, 54: 3277-3283. PMID: 17009262, DOI: 10.1002/art.22119.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusEnd-organ diseaseInflammatory skin diseaseMRL/Skin diseasesMRL/Faslpr miceFemale MRL/NF-kappaB inhibitorFlow cytometric analysisFaslpr miceAutoantibody titersIgG levelsLupus erythematosusLymph nodesRenal diseaseVehicle treatmentKidney diseaseHepatic toxicityTotal IgMTylophorine analogsAntichromatin autoantibodiesTherapeutic effectHistopathologic analysisMurine modelSignificant abrogation
1997
alpha beta T cell regulation and CD40 ligand dependence in murine systemic autoimmunity.
Peng SL, McNiff JM, Madaio MP, Ma J, Owen MJ, Flavell RA, Hayday AC, Craft J. alpha beta T cell regulation and CD40 ligand dependence in murine systemic autoimmunity. The Journal Of Immunology 1997, 158: 2464-70. PMID: 9036998, DOI: 10.4049/jimmunol.158.5.2464.Peer-Reviewed Original ResearchConceptsAlpha beta T cellsBeta T cellsGamma delta T cellsAutoimmune skin diseaseDelta T cellsT cellsRenal diseaseSystemic autoimmunitySkin diseasesAutoantibody productionMurine lupusCutaneous diseaseT cell-dependent mechanismAlpha betaHigh-titer autoantibodiesLupus-prone miceSevere renal diseaseCell-dependent mechanismT cell regulationCutaneous lesionsCD40 ligandAutoantibodiesAutoimmunityLow titersLpr animals