2019
Spatial and functional heterogeneity of follicular helper T cells in autoimmunity
Seth A, Craft J. Spatial and functional heterogeneity of follicular helper T cells in autoimmunity. Current Opinion In Immunology 2019, 61: 1-9. PMID: 31374450, PMCID: PMC7255639, DOI: 10.1016/j.coi.2019.06.005.Peer-Reviewed Original ResearchConceptsHelper T cellsFollicular helper T cellsT cellsB cell helper T cellsTfh cell biologyB cell folliclesB cell helpT helper cellsNon-lymphoid tissuesAutoantibody-mediated autoimmunitySecondary lymphoidAutoimmune diseasesHelper cellsCell helpGerminal centersAnimal modelsB cell developmentHuman patientsPathogenic changesAutoimmunityProduction of affinityExtrafollicular spaceTherapeutic purposesFunctional heterogeneityCell development
2014
Global transcriptome analysis and enhancer landscape of human primary T follicular helper and T effector lymphocytes
Weinstein JS, Lezon-Geyda K, Maksimova Y, Craft S, Zhang Y, Su M, Schulz VP, Craft J, Gallagher PG. Global transcriptome analysis and enhancer landscape of human primary T follicular helper and T effector lymphocytes. Blood 2014, 124: 3719-3729. PMID: 25331115, PMCID: PMC4263981, DOI: 10.1182/blood-2014-06-582700.Peer-Reviewed Original ResearchConceptsT-cell lymphomaTfh cellsHelper cellsPrimary cutaneous T-cell lymphomaAngioimmunoblastic T-cell lymphomaCutaneous T-cell lymphomaTfh cell functionFollicular helper cellsT effector cellsCell functionHuman Tfh cellsProtective humoral immunityT helper cellsLymphoid cell functionB cell maturationT lymphocyte developmentEffector cellsFollicular helperT effectorsAutoimmune diseasesHumoral immunityAntibody formationPlasma cellsGerminal centersLymphoid cells
2012
T cells that promote B‐Cell maturation in systemic autoimmunity
Weinstein JS, Hernandez SG, Craft J. T cells that promote B‐Cell maturation in systemic autoimmunity. Immunological Reviews 2012, 247: 160-171. PMID: 22500839, PMCID: PMC3334351, DOI: 10.1111/j.1600-065x.2012.01122.x.Peer-Reviewed Original ResearchConceptsSystemic autoimmunityT cellsB cell maturationExtrafollicular fociGerminal centersB cellsTfh cellsImmune responseFollicular helper T cellsT cell-dependent immune responsesEnd-organ injuryB cell folliclesSystemic autoimmune diseaseTfh cell developmentHuman Tfh cellsSelf-reactive B cellsT helper cellsHelper T cellsSecondary lymphoid organsNormal immune responseT cell helpPlasma cell formationPathogenic autoantibodiesLymph nodesAutoimmune diseases
2011
The characterization of thymus-derived natural Th17 cells and their response to inflammation. (108.9)
Nowyhed H, Bertino S, Tao J, Marks B, Choi J, Craft J. The characterization of thymus-derived natural Th17 cells and their response to inflammation. (108.9). The Journal Of Immunology 2011, 186: 108.9-108.9. DOI: 10.4049/jimmunol.186.supp.108.9.Peer-Reviewed Original ResearchNatural Th17 cellsNTh17 cellsTh17 cellsNatural T Regulatory CellsCD4 T helper cellsIL-22 secretionT regulatory (Treg) cellsCertain autoimmune conditionsFunction of Th1T helper cellsIL-17AAutoimmune conditionsRegulatory cellsIL-22Neutrophil recruitmentHelper cellsIL-1βSelf antigensIL-1R1Th1 cellsNTreg cellsIL-17RCTh2 cellsTissue destructionEffector lineages
2010
Thymic self-reactivity selects for natural Th17 cells which can be distinguished by unique markers (143.49)
Nowyhed H, Marks B, Choi J, Craft J. Thymic self-reactivity selects for natural Th17 cells which can be distinguished by unique markers (143.49). The Journal Of Immunology 2010, 184: 143.49-143.49. DOI: 10.4049/jimmunol.184.supp.143.49.Peer-Reviewed Original ResearchNatural Th17 cellsNTh17 cellsTh17 cellsIL-17RCIL-17RENatural T Regulatory CellsCD4 T helper cellsT regulatory (Treg) cellsIL-22 secretionCertain autoimmune conditionsFunction of Th1T helper cellsAutoimmune conditionsIL-17ARegulatory cellsNeutrophil recruitmentIL-22Self antigensHelper cellsTh1 cellsLevel of secretionNTreg cellsTh2 cellsTissue destructionEffector lineages