2024
Is Clot Composition Associated With Cause of Stroke? A Systematic Review and Meta‐Analysis
Sujijantarat N, Templeton K, Antonios J, Renedo D, Koo A, Haynes J, Fathima B, Amllay A, Nowicki K, Huttner A, Giles J, Navaratnam D, Sansing L, Hebert R, King J, Matouk C. Is Clot Composition Associated With Cause of Stroke? A Systematic Review and Meta‐Analysis. Stroke Vascular And Interventional Neurology 2024, 4 DOI: 10.1161/svin.124.001426.Peer-Reviewed Original ResearchCause of strokeRed blood cellsWhite blood cellsBlood cellsMechanical thrombectomyCardioembolic groupHistological compositionMeta-analysisLow red blood cellQuantity of red blood cellsRandom-effects meta-analysisAcute ischemic strokeEffects meta-analysisEnglish-language articlesMean percentage differenceAdult patientsMEDLINE databaseCochrane LibraryClinical utilityIschemic strokeLanguage articlesPatientsPercentage differenceArteryCellular compositionLumbocaval Shunt for Idiopathic Intracranial Hypertension: A Technical Report and Case Series
Sujijantarat N, Koo A, Elsamadicy A, Antonios J, Renedo D, Haynes J, Fathima B, Theriault B, Chavez M, Amllay A, Nowicki K, Kanzler M, Jiang J, Shekar A, Hebert R, DiLuna M, Matouk C. Lumbocaval Shunt for Idiopathic Intracranial Hypertension: A Technical Report and Case Series. Neurosurgery Open 2024, 5: e00113. DOI: 10.1227/neuprac.0000000000000113.Peer-Reviewed Original ResearchIdiopathic intracranial hypertensionIntracranial hypertensionTreatment of idiopathic intracranial hypertensionManagement of idiopathic intracranial hypertensionMedical records of patientsAssessment of long-term outcomesHigh-pressure headachesMedian operative timeDifficult-to-manage patientsLow-pressure headacheCerebrospinal fluid shuntsElectronic medical records of patientsRecords of patientsFollow-up visitLong-term outcomesLumbar shuntDifficult-to-manage casesIntraoperative complicationsShunt revisionImprove headacheCase seriesEarly outcomesSurgical techniqueNeurosurgical managementOperative timeImprovement in cranial nerve palsies following treatment of intracranial aneurysms with flow diverters: Institutional outcomes, systematic review and study-level meta-analysis
Sujijantarat N, Antonios J, Renedo D, Koo A, Haynes J, Fathima B, Jiang J, Hengartner A, Shekhar A, Amllay A, Nowicki K, Hebert R, Gilmore E, Sheth K, King J, Matouk C. Improvement in cranial nerve palsies following treatment of intracranial aneurysms with flow diverters: Institutional outcomes, systematic review and study-level meta-analysis. Clinical Neurology And Neurosurgery 2024, 246: 108555. PMID: 39357321, DOI: 10.1016/j.clineuro.2024.108555.Peer-Reviewed Original ResearchStudy-level meta-analysisRate of improvementCN deficitsMeta-analysisIntracranial aneurysmsCN palsySystematic reviewFactors associated with recoveryPooled rateRandom-effects meta-analysisCranial nervesManual citation searchingEffects meta-analysisRate of clinical improvementCranial nerve palsyMechanism of injuryIncreased rate of improvementFlow diversionRare presenting symptomSymptomatic intracranial aneurysmsTreatment of intracranial aneurysmsCitation searchingPalsyNerve palsyRetrospective reviewO14 One-year safety of treating communicating hydrocephalus with the eShunt® implant
Lylyk P, Matouk C, Riina H, Siddiqui A, Lylyk I, Bleise C, Scrivano E, Lylyk P, Antonios J, Beneduce B, Levy E, Heilman C, Malek A. O14 One-year safety of treating communicating hydrocephalus with the eShunt® implant. 2024, a9.1-a9. DOI: 10.1136/jnis-2024-esmint.14.Peer-Reviewed Original ResearchHigher proceduralist stroke thrombectomy volume is associated with reduced inpatient mortality
Koo A, Renedo D, Ney J, Amllay A, Kanzler M, Stogniy S, Alawieh A, Sujijantarat N, Antonios J, Al Kasab S, Malhotra A, Hebert R, Matouk C, de Havenon A. Higher proceduralist stroke thrombectomy volume is associated with reduced inpatient mortality. Journal Of NeuroInterventional Surgery 2024, jnis-2024-022021. PMID: 39214687, DOI: 10.1136/jnis-2024-022021.Peer-Reviewed Original ResearchIn-hospital deathIn-hospital mortalityAcute ischemic strokeCut-pointsAbsolute risk of deathAssociated with lower oddsState Inpatient DatabasesFlorida State Inpatient DatabaseIn-hospital moralityRates of in-hospital mortalityDiagnosis of acute ischemic strokePrimary study outcomeRisk of deathStroke careOptimal cut-pointAssociated with reduced inpatient mortalityEndovascular thrombectomyRetrospective cohort studyLower oddsPotential confoundersAbsolute riskAcute ischemic stroke patientsInpatient mortalityCohort studyInpatient DatabaseO-035 Higher endovascular thrombectomy procedural volume is associated with reduced inpatient mortality
Koo A, Renedo D, Ney J, Amllay A, Kanzler M, Stogniy S, Nowicki K, Alawieh A, Sujijantarat N, Antonios J, Al Kasab S, Hebert R, Matouk C, de Havenon A. O-035 Higher endovascular thrombectomy procedural volume is associated with reduced inpatient mortality. 2024, a27.2-a28. DOI: 10.1136/jnis-2024-snis.35.Peer-Reviewed Original ResearchO-037 One-year follow-up of the eShunt® System for the treatment of normal pressure hydrocephalus
Lylyk P, Matouk C, Siddiqui A, Riina H, Lylyk I, Bleise C, Scrivano E, Lylyk P, Antonios J, Beneduce B, Levy E, Heilman C, Malek A. O-037 One-year follow-up of the eShunt® System for the treatment of normal pressure hydrocephalus. 2024, a29.1-a29. DOI: 10.1136/jnis-2024-snis.37.Peer-Reviewed Original ResearchP-031 One-year safety of the eShunt® implant used in the treatment of communicating hydrocephalus
Lylyk P, Matouk C, Siddiqui A, Riina H, Lylyk I, Bleise C, Scrivano E, Lylyk P, Antonios J, Beneduce B, Levy E, Heilman C, Malek A. P-031 One-year safety of the eShunt® implant used in the treatment of communicating hydrocephalus. 2024, a78.1-a78. DOI: 10.1136/jnis-2024-snis.103.Peer-Reviewed Original ResearchAuthor Correction: TLR agonists polarize interferon responses in conjunction with dendritic cell vaccination in malignant glioma: a randomized phase II Trial
Everson R, Hugo W, Sun L, Antonios J, Lee A, Ding L, Bu M, Khattab S, Chavez C, Billingslea-Yoon E, Salazar A, Ellingson B, Cloughesy T, Liau L, Prins R. Author Correction: TLR agonists polarize interferon responses in conjunction with dendritic cell vaccination in malignant glioma: a randomized phase II Trial. Nature Communications 2024, 15: 4800. PMID: 38839763, PMCID: PMC11153605, DOI: 10.1038/s41467-024-48995-7.Peer-Reviewed Original ResearchTLR agonists polarize interferon responses in conjunction with dendritic cell vaccination in malignant glioma: a randomized phase II Trial
Everson R, Hugo W, Sun L, Antonios J, Lee A, Ding L, Bu M, Khattab S, Chavez C, Billingslea-Yoon E, Salazar A, Ellingson B, Cloughesy T, Liau L, Prins R. TLR agonists polarize interferon responses in conjunction with dendritic cell vaccination in malignant glioma: a randomized phase II Trial. Nature Communications 2024, 15: 3882. PMID: 38719809, PMCID: PMC11078958, DOI: 10.1038/s41467-024-48073-y.Peer-Reviewed Original ResearchConceptsAutologous tumor lysate-pulsed dendritic cellCD8+ T cellsT cellsPoly-ICLCTLR agonistsMalignant gliomasTumor lysate-pulsed dendritic cellsRandomized phase II trialCD4+ T cellsRandomized phase II clinical trialInterferon responsePhase II clinical trialPoly-ICLC treatmentDendritic cell vaccinesPD-1 expressionPhase II trialInterferon responsive gene expressionSystemic immune responsesImmune cell activationII clinical trialsInduction of interferon-inducible genesDelay disease progressionInterferon gene expressionInterferon-inducible genesPD-1Use of a dedicated open transcarotid access system for neurovascular disease
Sujijantarat N, Renedo D, Antonios J, Koo A, Amllay A, Nowicki K, Cord B, Hebert R, de Havenon A, Sheth K, Petersen N, Matouk C. Use of a dedicated open transcarotid access system for neurovascular disease. Journal Of NeuroInterventional Surgery 2024, jnis-2024-021599. PMID: 38719442, DOI: 10.1136/jnis-2024-021599.Peer-Reviewed Original ResearchExtracranial carotid stenosisTranscarotid artery revascularizationNeurovascular diseasesCarotid stenosisDatabase of consecutive patientsNeurovascular pathologyTreatment of neurovascular diseasesAccess-related complicationsTreatment of neurovascular pathologiesOff-label useCarotid flow reversalConsecutive patientsRetrospective reviewIntracranial atherosclerotic diseasePeriprocedural complicationsEndovascular treatmentArtery revascularizationProcedural characteristicsArterial sheathCarotid diseaseAcademic centersIntracranial aneurysmsPatientsTranscarotid approachTransradial approachAngiographic evidence of an inadvertent cannulation of the marginal sinus following central line migration: illustrative case
Amllay A, Owolo E, Nowicki K, Sujijantarat N, Koo A, Antonios J, Renedo D, Matouk C, Hebert R. Angiographic evidence of an inadvertent cannulation of the marginal sinus following central line migration: illustrative case. Journal Of Neurosurgery Case Lessons 2024, 7: case23607. PMID: 38684119, PMCID: PMC11058405, DOI: 10.3171/case23607.Peer-Reviewed Original ResearchCentral venous catheterInternal jugular veinCatheter tip migrationTip migrationMalpositioned cathetersAbsence of contrast extravasationSinus cannulationTriple-lumen central venous catheterAortic valve replacementInadvertent cannulationCatheter malpositionContrast extravasationValve replacementSigmoid sinusImprove patient outcomesPosterior fossaEndovascular managementSevere complicationsVenous cathetersWeeks postinsertionPrompt managementAngiographic evidenceCatheter exchangeReduce morbidityInterventional suiteThe eShunt® System: A Novel Minimally Invasive CSF Shunting System for the Treatment of Idiopathic Normal Pressure Hydrocephalus (P10-4.014)
Lylyk P, Matouk C, Siddiqui A, Riina H, Lylyk I, Bleise C, Scrivano E, Lylyk P, Antonios J, Beneduce B, Levy E, Heilman C, Malek A. The eShunt® System: A Novel Minimally Invasive CSF Shunting System for the Treatment of Idiopathic Normal Pressure Hydrocephalus (P10-4.014). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000206181.Peer-Reviewed Original Research306 Endothelial Infiltrating Regulatory B Cells and NK T Cells Precipitate Inflammatory Cascade That Leads to Aneurysmal Rupture
Antonios J, Barak T, Gultekin B, Yalcin K, Adenu-Mensah N, Sujijantarat N, Koo A, Haynes J, Hebert R, Matouk C, Gunel M. 306 Endothelial Infiltrating Regulatory B Cells and NK T Cells Precipitate Inflammatory Cascade That Leads to Aneurysmal Rupture. Neurosurgery 2024, 70: 88-89. DOI: 10.1227/neu.0000000000002809_306.Peer-Reviewed Original ResearchRegulatory B cellsB cellsSentinel hemorrhageNK cellsInflammatory cascadeCytotoxic CD8 T cellsRecruitment of NK cellsCD8 T cellsAdjunctive immune therapyEndovascular coil embolizationCoordinated immune responseIntracranial aneurysm developmentImmune therapyRecurrent aneurysmsAneurysmal vessel wallT cellsCoil embolizationRuptured aneurysmsTime of ruptureAneurysm ruptureUnruptured aneurysmsInfiltrating populationPatient populationImmune responseAneurysm development308 Improvement in Cranial Nerve Neuropathies Following Treatment of Intracranial Aneurysms With Flow Diverters: Institutional Outcomes and Meta-analysis of Literature
Sujijantarat N, Antonios J, Koo A, Haynes J, Renedo D, Hebert R, Sheth K, King J, Matouk C. 308 Improvement in Cranial Nerve Neuropathies Following Treatment of Intracranial Aneurysms With Flow Diverters: Institutional Outcomes and Meta-analysis of Literature. Neurosurgery 2024, 70: 89-89. DOI: 10.1227/neu.0000000000002809_308.Peer-Reviewed Original ResearchIntracranial aneurysmsPooled rateMeta-analysisCranial nervesRate of clinical improvementNear total occlusionAneurysms treated with flow diversionCranial nerve neuropathyMonths of presentationFlow diversionAssociated with symptomatic improvementRare presenting symptomSymptomatic intracranial aneurysmsRate of improvementTreatment of intracranial aneurysmsRandom-effects meta-analysisMeta-analysis of literatureEffects meta-analysisOphthalmological outcomesCN deficitsRetrospective reviewAssociated with improvementsClinical improvementNerve neuropathySymptomatic improvement157 Minimally Invasive Treatment of Idiopathic Normal Pressure Hydrocephalus Using the Endovascular eShunt Implant
Lylyk P, Matouk C, Siddiqui A, Lylyk I, Bleise C, Scrivano E, Lylyk N, Antonios J, Beneduce B, Levy E, Heilman C, Malek A. 157 Minimally Invasive Treatment of Idiopathic Normal Pressure Hydrocephalus Using the Endovascular eShunt Implant. Neurosurgery 2024, 70: 36-37. DOI: 10.1227/neu.0000000000002809_157.Peer-Reviewed Original ResearchNeurogenic Bladder Symptom ScoreComposite outcome scoreNormal pressure hydrocephalusIdiopathic normal pressure hydrocephalusOutcome scoresVentriculo-peritoneal shunt surgeryTimed Up &Treatment of idiopathic normal pressure hydrocephalusPressure hydrocephalusTreat communicating hydrocephalusFavorable risk profileFunctional outcome scoresMinimally invasive treatmentFollow-up dataMontreal Cognitive AssessmentCompared to baselineGait improvementFollow-up phaseShunt surgeryUrinary continenceCSF shuntingUrinary incontinenceElderly patientsPre-treatment scoresFollow-up
2023
Low‐Field Portable Magnetic Resonance Imaging for Post‐Thrombectomy Assessment of Ongoing Brain Injury
Sujijantarat N, Koo A, Jambor I, Malhotra A, Mazurek M, Parasuram N, Yadlapalli V, Chavva I, Lalwani D, Zabinska J, Roy J, Antonios J, Elsamadicy A, Renedo D, Hebert R, Schindler J, Gilmore E, Sansing L, de Havenon A, Olexa M, Schiff S, Iglesias J, Rosen M, Kimberly W, Petersen N, Sheth K, Matouk C. Low‐Field Portable Magnetic Resonance Imaging for Post‐Thrombectomy Assessment of Ongoing Brain Injury. Stroke Vascular And Interventional Neurology 2023, 3 DOI: 10.1161/svin.123.000921.Peer-Reviewed Original ResearchMechanical thrombectomyInterventional radiology suiteMagnetic resonance imagingRadiology suiteConventional MRIResonance imagingCerebral Infarction scoreOngoing brain injuryLarge vessel occlusionInfarct burdenRevascularization timeInfarct volumeClinical characteristicsInfarct progressionAdverse eventsIschemic changesMethods PatientsMedian timeBedside evaluationBrain injuryTimely imagingResults TwentyPatientsSubsequent imagingProcedural detailsO-068 Regulatory B cell and adjunctive immune population drives intracranial aneurysm rupture in patient population
Antonios J, Barak T, Gultekin B, Yalcin K, Chamberlain A, Hebert R, Matouk C, Gunel M. O-068 Regulatory B cell and adjunctive immune population drives intracranial aneurysm rupture in patient population. 2023, a53.1-a53. DOI: 10.1136/jnis-2023-snis.68.Peer-Reviewed Original ResearchO-039 Preliminary results of the cerevasc eShunt implant in the treatment of normal pressure hydrocephalus
Lylyk P, Matouk C, Siddiqui A, Lylyk I, Bleise C, Scrivano E, Lylyk N, Antonios J, Beneduce B, Levy E, Heilman C, Malek A. O-039 Preliminary results of the cerevasc eShunt implant in the treatment of normal pressure hydrocephalus. 2023, a31-a32. DOI: 10.1136/jnis-2023-snis.39.Peer-Reviewed Original Research
2022
Stereotactic radiosurgery and local control of brain metastases from triple-negative breast cancer.
Kowalchuk R, Niranjan A, Hess J, Antonios J, Zhang M, Braunstein S, Ross R, Pikis S, Deibert C, Lee C, Yang H, Langlois A, Mathieu D, Peker S, Samanci Y, Rusthoven C, Chiang V, Wei Z, Lunsford L, Trifiletti D, Sheehan J. Stereotactic radiosurgery and local control of brain metastases from triple-negative breast cancer. Journal Of Neurosurgery 2022, 138: 1608-1614. PMID: 36433878, DOI: 10.3171/2022.10.jns221900.Peer-Reviewed Original ResearchTriple-negative breast cancerLocal tumor progressionStereotactic radiosurgeryBreast cancerOverall survivalMetastatic lesionsPerformance statusLocal controlTriple-negative breast cancer metastasisMedian Karnofsky performance statusTumor progressionWhole-brain radiation therapyFavorable performance statusMedian margin dosePrior stereotactic radiosurgerySymptomatic radiation necrosisKarnofsky performance statusIntracranial metastatic diseaseRetrospective chart reviewLocal tumor controlBreast cancer metastasisIntracranial metastatic lesionsMargin doseMultiinstitutional cohortBrain metastases