2013
Parathyroid Hormone-Related Protein Specifies the Mammary Mesenchyme and Regulates Embryonic Mammary Development
Hiremath M, Wysolmerski J. Parathyroid Hormone-Related Protein Specifies the Mammary Mesenchyme and Regulates Embryonic Mammary Development. Journal Of Mammary Gland Biology And Neoplasia 2013, 18: 171-177. PMID: 23640717, PMCID: PMC3696739, DOI: 10.1007/s10911-013-9283-7.BooksConceptsParathyroid hormoneBreast cancerMammary rudimentsMammary budLoss of PTHrPOverexpression of PTHrPRole of PTHrPEffects of PTHrPNovel breast cancer susceptibility lociEpithelial-stromal crosstalkEmbryonic mammary budBreast cancer susceptibility lociEmbryonic mammary developmentMammary gland morphogenesisNipple skinDay 15PTHrP’s rolePTHrPMammary developmentMammary epithelial identityMammary mesenchymeCancer susceptibility lociCancerCritical regulatorHormone
2004
Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis
Chu EY, Hens J, Andl T, Kairo A, Yamaguchi TP, Brisken C, Glick A, Wysolmerski JJ, Millar SE. Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development 2004, 131: 4819-4829. PMID: 15342465, DOI: 10.1242/dev.01347.Peer-Reviewed Original ResearchConceptsMammary gland morphogenesisPlacode developmentGland morphogenesisCanonical WntEmbryonic mammary developmentMammary placode formationHair follicle formationSkin appendage morphogenesisWnt pathway activityAdditional WntAppendage morphogenesisWnt signalsPlacode formationWnt genesMolecular controlMammary morphogenesisMammary placodesUnderlying mesenchymeMorphogenesisWnt pathwayWntPathway activityWnt inhibitor Dickkopf-1PlacodeElevated expression