Featured Publications
Confluence of Timing and Reward Biases in Perceptual Decision-Making Dynamics
Shinn M, Ehrlich D, Lee D, Murray JD, Seo H. Confluence of Timing and Reward Biases in Perceptual Decision-Making Dynamics. Journal Of Neuroscience 2020, 40: 7326-7342. PMID: 32839233, PMCID: PMC7534922, DOI: 10.1523/jneurosci.0544-20.2020.Peer-Reviewed Original ResearchConceptsDecision-making taskReward biasesDecision-making strategiesPerceptual decision-making taskNovel decision-making taskGeneralized drift-diffusion modelsResponse time patternsTiming mechanismTemporal structureCognitive mechanismsSensory evidenceDecision-making dynamicsUrgency signalAsymmetric rewardsNeural mechanismsStimulus timingDrift-diffusion modelTemporal contextLeaky integrationRewardReward structureTemporal uncertaintyEvidence reliabilityEveryday lifeSuch regularitiesA circuit mechanism for decision-making biases and NMDA receptor hypofunction
Cavanagh SE, Lam NH, Murray JD, Hunt LT, Kennerley SW. A circuit mechanism for decision-making biases and NMDA receptor hypofunction. ELife 2020, 9: e53664. PMID: 32988455, PMCID: PMC7524553, DOI: 10.7554/elife.53664.Peer-Reviewed Original ResearchConceptsNMDA-R hypofunctionCortical excitation/inhibition balanceExcitation/inhibition balanceNMDA receptor hypofunctionNMDA receptor antagonismNMDA-R antagonist ketamineCircuit-level mechanismsPotential neural mechanismsNeuropsychiatric symptomsReceptor hypofunctionReceptor antagonismInhibition balanceExcitatory neuronsInhibitory neuronsPharmacological modelPharmacological manipulationNeuropsychiatric disordersCircuit mechanismsHypofunctionVariable evidenceNeural mechanismsKetamineNeuronsBehavioral psychophysicsPossible effectsTrial-to-Trial Variability of Spiking Delay Activity in Prefrontal Cortex Constrains Burst-Coding Models of Working Memory
Li D, Constantinidis C, Murray JD. Trial-to-Trial Variability of Spiking Delay Activity in Prefrontal Cortex Constrains Burst-Coding Models of Working Memory. Journal Of Neuroscience 2021, 41: 8928-8945. PMID: 34551937, PMCID: PMC8549532, DOI: 10.1523/jneurosci.0167-21.2021.Peer-Reviewed Original ResearchTransient neuronal suppression for exploitation of new sensory evidence
Shinn M, Lee D, Murray JD, Seo H. Transient neuronal suppression for exploitation of new sensory evidence. Nature Communications 2022, 13: 23. PMID: 35013222, PMCID: PMC8748884, DOI: 10.1038/s41467-021-27697-4.Peer-Reviewed Original ResearchConceptsSensory evidenceNeural activityNew sensory evidenceGeneralized drift-diffusion modelsBehavioral responsesFrontal eye fieldConsistency of behaviorMultiple brain areasPerceptual decisionsEvidence accumulationStimulus onsetAnimal's behavioral responseMotor preparationDrift-diffusion modelEye fieldMomentary arrestTemporal integrationBehavioral studiesBrain areasCorresponding dipMotor outputBrief suppressionNeuronal suppressionVariable delayStimulus strength
2024
Human brain state dynamics are highly reproducible and associated with neural and behavioral features
Lee K, Ji J, Fonteneau C, Berkovitch L, Rahmati M, Pan L, Repovš G, Krystal J, Murray J, Anticevic A. Human brain state dynamics are highly reproducible and associated with neural and behavioral features. PLOS Biology 2024, 22: e3002808. PMID: 39316635, PMCID: PMC11421804, DOI: 10.1371/journal.pbio.3002808.Peer-Reviewed Original ResearchConceptsCo-activation patternsResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingBehavioral featuresNeural variationsMoment-to-moment changesSingle-subject levelBrain state dynamicsEmotion regulationHealthy young adultsBehavioral phenotypesCognitive functionSubstance useNeural activityNeuroimaging markersNeural featuresYoung adultsMagnetic resonance imagingCo-activationResonance imagingCo-variationNeuroimagingIndividualsEmotionsFunctional outcomesIndividual differences in spatial working memory strategies differentially reflected in the engagement of control and default brain networks
Suljič N, Kraljič A, Rahmati M, Cho Y, Ozimič A, Murray J, Anticevic A, Repovš G. Individual differences in spatial working memory strategies differentially reflected in the engagement of control and default brain networks. Cerebral Cortex 2024, 34: bhae350. PMID: 39214852, PMCID: PMC11364466, DOI: 10.1093/cercor/bhae350.Peer-Reviewed Original ResearchConceptsCategorical representationsWorking memoryBrain activityFunctional magnetic resonance imaging studySpatial working memory strategySpatial working memory taskFrontoparietal network activitySpatial working memoryWorking memory taskEngagement of controlAssociated with distinct patternsWorking memory strategiesMagnetic resonance imaging studiesNetwork activityMemory taskBrain systemsAttentional resourcesTask trialsBrain networksMemory strategiesStimulus informationStronger deactivationTiming of stimuliHealthy participantsSpatial representation