2006
Decreased Cerebrospinal Fluid Allopregnanolone Levels in Women with Posttraumatic Stress Disorder
Rasmusson AM, Pinna G, Paliwal P, Weisman D, Gottschalk C, Charney D, Krystal J, Guidotti A. Decreased Cerebrospinal Fluid Allopregnanolone Levels in Women with Posttraumatic Stress Disorder. Biological Psychiatry 2006, 60: 704-713. PMID: 16934764, DOI: 10.1016/j.biopsych.2006.03.026.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderPremenopausal womenALLO levelsStress disorderCerebrospinal fluid levelsPTSD re-experiencing symptomsAllopregnanolone levelsOral contraceptivesGABAergic neurotransmissionDHEAS levelsPsychotropic medicationsFollicular phaseMenstrual cycleDHEA ratioExcitatory neurotransmissionNeurotransmitter systemsRe-experiencing symptomsDepressive symptomsPTSD subjectsFluid levelsGroup differencesIllicit drugsWomenNeurotransmissionProgesterone
2002
Cortical γ-Aminobutyric Acid Levels Across the Menstrual Cycle in Healthy Women and Those With Premenstrual Dysphoric Disorder: A Proton Magnetic Resonance Spectroscopy Study
Epperson CN, Haga K, Mason GF, Sellers E, Gueorguieva R, Zhang W, Weiss E, Rothman DL, Krystal JH. Cortical γ-Aminobutyric Acid Levels Across the Menstrual Cycle in Healthy Women and Those With Premenstrual Dysphoric Disorder: A Proton Magnetic Resonance Spectroscopy Study. JAMA Psychiatry 2002, 59: 851-858. PMID: 12215085, DOI: 10.1001/archpsyc.59.9.851.Peer-Reviewed Original ResearchConceptsPremenstrual dysphoric disorderCortical GABA levelsGABA neuronal functionBrain GABA concentrationsHealthy womenMenstrual cycleGABA levelsNeuronal functionNeuroactive steroidsFollicular phaseDysphoric disorderGABA concentrationOccipital cortex GABA levelsProton magnetic resonance spectroscopy studyUniversity-based medical centerHealthy menstruating womenΓ-aminobutyric acid (GABA) levelsMagnetic resonance spectroscopy studyLate luteal phaseMenstrual cycle phaseHealth Research programmeMid lutealNeurosteroid levelsGABAergic systemMenstruating women