2020
Education and Socioeconomic Status Mask the Identification of Brain Cell Types in GWAS of Mental Health and Disease
Wendt F, Pathak G, Lencz T, Krystal J, Gelernter J, Polimanti R. Education and Socioeconomic Status Mask the Identification of Brain Cell Types in GWAS of Mental Health and Disease. Biological Psychiatry 2020, 87: s110. DOI: 10.1016/j.biopsych.2020.02.302.Peer-Reviewed Original Research
2019
A Unique Brain Connectome Fingerprint Predates and Predicts Response to Antidepressants
Nemati S, Akiki TJ, Roscoe J, Ju Y, Averill CL, Fouda S, Dutta A, McKie S, Krystal JH, Deakin JFW, Averill LA, Abdallah CG. A Unique Brain Connectome Fingerprint Predates and Predicts Response to Antidepressants. IScience 2019, 23: 100800. PMID: 31918047, PMCID: PMC6992944, DOI: 10.1016/j.isci.2019.100800.Peer-Reviewed Original ResearchMonoaminergic antidepressantsAcute neurochemical effectsMechanism of actionMonoaminergic actionsBrain functional connectomeNeurochemical effectsTherapeutic effectAntidepressantsConnectomics signaturesEarly changesBrain functionConnectome fingerprintFunctional connectomeConnectivity architectureDiseaseWeeksMonthsResponse
2016
Moderate Alcohol Consumption and Chronic Disease: The Case for a Long‐Term Trial
Mukamal KJ, Clowry CM, Murray MM, Hendriks HF, Rimm EB, Sink KM, Adebamowo CA, Dragsted LO, Lapinski PS, Lazo M, Krystal JH. Moderate Alcohol Consumption and Chronic Disease: The Case for a Long‐Term Trial. Alcohol Clinical And Experimental Research 2016, 40: 2283-2291. PMID: 27688006, PMCID: PMC5073014, DOI: 10.1111/acer.13231.Peer-Reviewed Original ResearchConceptsModerate alcohol consumptionChronic diseasesAlcohol consumptionRandomized trialsLong-term clinical trialsCoronary heart diseaseMajor chronic diseasesStrong epidemiological associationLong-term trialsGold standard evidenceNutritional interventionHeart diseaseClinical trialsBreast cancerEpidemiological associationModerate drinkingYears durationClinical investigatorsBiological mediatorsAvailable evidenceDiseaseObserved associationsTrialsStandard evidenceVariety of settings
2015
Significant association between rare IPO11‐HTR1A variants and attention deficit hyperactivity disorder in Caucasians
Zuo L, Saba L, Lin X, Tan Y, Wang K, Krystal JH, Tabakoff B, Luo X. Significant association between rare IPO11‐HTR1A variants and attention deficit hyperactivity disorder in Caucasians. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2015, 168: 544-556. PMID: 26079129, PMCID: PMC4851708, DOI: 10.1002/ajmg.b.32329.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAttention Deficit Disorder with HyperactivityBeta KaryopherinsBlack or African AmericanFemaleGene FrequencyGenetic Predisposition to DiseaseGenetic VariationHumansMaleMiddle AgedPolymorphism, Single NucleotideQuantitative Trait LociReceptor, Serotonin, 5-HT1ARisk FactorsWhite PeopleConceptsAttention deficit hyperactivity disorderDeficit hyperactivity disorderNeuropsychiatric disordersRare variantsHyperactivity disorderDifferent neuropsychiatric disordersRNA expression changesIndependent cohortSignificant associationSignificant regulatory effectDisordersCaucasiansEuropean descentRegulatory effectsHuman brainDiseaseAssociationCis-eQTL analysisIPO11African descentExpression changesSubjectsCohortFalse discovery rateVariants
2013
Translational cognitive neuroscience of schizophrenia: bridging neurocognitive and computational approaches toward understanding cognitive deficits
Anticevic A, Krystal J, Barch D. Translational cognitive neuroscience of schizophrenia: bridging neurocognitive and computational approaches toward understanding cognitive deficits. 2013, 193-230. DOI: 10.1017/cbo9781139003872.013.Peer-Reviewed Original ResearchCognitive deficitsCognitive neuroscienceCourse of impairmentSevere mental illnessDeficitsSchizophreniaMental illnessPharmacological techniquesBiological contributionPrecise mechanismNeuroscienceIllnessLittle disputeRelated featuresStyleFunctional implicationsImpairmentManagement optionsImplicationsDisabilityPatientsSymptomsCliniciansDisease
2012
The role of default network deactivation in cognition and disease
Anticevic A, Cole MW, Murray JD, Corlett PR, Wang XJ, Krystal JH. The role of default network deactivation in cognition and disease. Trends In Cognitive Sciences 2012, 16: 584-592. PMID: 23142417, PMCID: PMC3501603, DOI: 10.1016/j.tics.2012.10.008.Peer-Reviewed Original ResearchConceptsDMN suppressionDefault network deactivationGoal-directed cognitionSpecific behavioral tasksDefault mode networkCognitive neurosciencePharmacological neuroimagingSuppression deficitsBehavioral tasksFocused attentionClinical neuroscienceTheoretical neuroscienceBrain regionsNeuroscienceCognitionSevere mental illnessMental illnessConsiderable bodyNeuroimagingTaskDeficitsDMNExternal environmentMindDisease
2006
MR spectroscopy: its potential role for drug development for the treatment of psychiatric diseases
Mason GF, Krystal JH. MR spectroscopy: its potential role for drug development for the treatment of psychiatric diseases. NMR In Biomedicine 2006, 19: 690-701. PMID: 16986118, DOI: 10.1002/nbm.1080.Peer-Reviewed Original ResearchConceptsPsychiatric diseasesMagnetic resonance spectroscopyGlial abnormalitiesPsychiatric disordersBiochemical markersNon-invasive techniqueNeuropsychiatric disordersPotential roleDrug developmentDrug discoveryMRS techniquesDiseaseDisordersStudy of mechanismsTreatmentLines of investigationAbnormalitiesNeurochemistryDrug delivery
1999
NMDA Agonists and Antagonists as Probes of Glutamatergic Dysfunction and Pharmacotherapies in Neuropsychiatric Disorders
Krystal J, D'Souza C, Petrakis I, Belger A, Berman R, Charney D, AbiSaab W, Madonick S. NMDA Agonists and Antagonists as Probes of Glutamatergic Dysfunction and Pharmacotherapies in Neuropsychiatric Disorders. Harvard Review Of Psychiatry 1999, 7: 125-143. PMID: 10483932, DOI: 10.3109/hrp.7.3.125.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate (NMDA) subclassChronic pain syndromePain syndromeGlutamatergic dysfunctionNMDA agonistClinical studiesMajor depressionNMDA antagonistsGlutamate receptorsCoagonist siteParkinson's diseaseHuman psychopharmacological studiesPartial agonistAlzheimer's diseaseNeuropsychiatric conditionsNeuropsychiatric disordersDiseasePsychopharmacological studiesAnxiety disordersHuntington's diseaseAgonistsAntagonistTherapeutic hypothesesDisordersAddiction disordersPreliminary Evidence of Low Cortical GABA Levels in Localized 1H-MR Spectra of Alcohol-Dependent and Hepatic Encephalopathy Patients
Behar KL, Rothman DL, Petersen KF, Hooten M, Delaney R, Petroff OA, Shulman GI, Navarro V, Petrakis IL, Charney DS, Krystal JH. Preliminary Evidence of Low Cortical GABA Levels in Localized 1H-MR Spectra of Alcohol-Dependent and Hepatic Encephalopathy Patients. American Journal Of Psychiatry 1999, 156: 952-954. PMID: 10360140, DOI: 10.1176/ajp.156.6.952.Peer-Reviewed Original ResearchConceptsHepatic encephalopathy patientsEncephalopathy patientsGamma-aminobutyric acidHealthy subjectsCortical GABA levelsGABA-ergic systemDetoxified alcohol-dependent patientsAlcohol-dependent patientsNeuroactive amino acidsCerebral cortexGABA levelsOccipital cortexPatientsMetabolite levelsPreliminary evidenceCortexSubjectsLevelsDisease