2004
Allelic and haplotypic association of GABRA2 with alcohol dependence
Covault J, Gelernter J, Hesselbrock V, Nellissery M, Kranzler HR. Allelic and haplotypic association of GABRA2 with alcohol dependence. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2004, 129B: 104-109. PMID: 15274050, DOI: 10.1002/ajmg.b.30091.Peer-Reviewed Original ResearchConceptsAlcohol-dependent subjectsAlcohol dependenceSingle nucleotide polymorphismsMajor depressive episodeGABAA receptor subunitsSubstance use disordersHaplotypic associationsEvidence of associationSerious morbidityOpioid dependenceAlpha 2 subunitDepressive episodePrevalent disorderUse disordersEuropean-American subjectsNeurotransmitter receptorsControl groupDrug dependenceReceptor subunitsCommon haplotypeGABRA2 geneBehavioral effectsImportant mediatorAssociationSubjects
2003
CALCYON gene variation, schizophrenia, and cocaine dependence
Luo X, Kranzler H, Lappalainen J, Rosenheck R, Charney D, Zuo L, Erdos J, van Kammen DP, Gelernter J. CALCYON gene variation, schizophrenia, and cocaine dependence. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2003, 125B: 25-30. PMID: 14755439, DOI: 10.1002/ajmg.b.20092.Peer-Reviewed Original ResearchConceptsCocaine dependenceSingle nucleotide polymorphismsExact testEA subjectsFisher's exact testSubstance use disordersCalcyon geneDopamine receptor-interacting proteinsComparison of alleleUse disordersEuropean-American subjectsControl groupAA subjectsSchizophreniaReceptor-interacting proteinHaplotype frequenciesPotential roleSpecific polymorphismsMotor controlGene variationSame haplotype blockGenetic variantsSubjectsNucleotide polymorphismsLinkage disequilibriumAlleles of a Functional Serotonin Transporter Promoter Polymorphism Are Associated With Major Depression in Alcoholics
Nellissery M, Feinn RS, Covault J, Gelernter J, Anton RF, Pettinati H, Moak D, Mueller T, Kranzler HR. Alleles of a Functional Serotonin Transporter Promoter Polymorphism Are Associated With Major Depression in Alcoholics. Alcohol Clinical And Experimental Research 2003, 27: 1402-1408. PMID: 14506400, DOI: 10.1097/01.alc.0000085588.11073.bb.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismAllelesBlack PeopleCarrier ProteinsChromosome MappingComorbidityDepressive Disorder, MajorFemaleGene FrequencyGenotypeHumansMaleMembrane GlycoproteinsMembrane Transport ProteinsMiddle AgedNerve Tissue ProteinsPhenotypePolymerase Chain ReactionPolymorphism, GeneticPromoter Regions, GeneticSerotonin Plasma Membrane Transport ProteinsWhite PeopleConceptsMajor depressionComorbid alcohol dependenceAlcohol dependenceFunctional serotonin transporter promoter polymorphismAfrican American patientsSubstance use disordersSerotonin transporter promoter polymorphismShort alleleTransporter promoter polymorphismSerotonin transporter proteinAntidepressant treatmentPatient groupAmerican patientsSerotonergic neurotransmissionDepressed alcoholicsMood disordersPromoter polymorphismUnipolar depressionUse disordersControl groupTreatment studiesFunctional polymorphismsGenetic predictorsSerotonin transporterWhole blood
2001
Case control and family‐based studies of tryptophan hydroxylase gene A218C polymorphism and suicidality in adolescents
Zalsman G, Frisch A, King R, Pauls D, Grice D, Gelernter J, Alsobrook J, Michaelovsky E, Apter A, Tyano S, Weizman A, Leckman J. Case control and family‐based studies of tryptophan hydroxylase gene A218C polymorphism and suicidality in adolescents. American Journal Of Medical Genetics 2001, 105: 451-457. PMID: 11449398, DOI: 10.1002/ajmg.1406.Peer-Reviewed Original ResearchConceptsSuicidal behaviorSuicide riskA218C polymorphismDetailed clinical historyHaplotype relative riskAssociation of suicidalityTransmission disequilibrium test (TDT) methodsTryptophan hydroxylase geneAdolescent suicidal behaviorClinical historySame ethnic populationRelative riskCase controlAA genotypeControl groupFamily-based studySuicide intentSignificant allelic associationSignificant differencesEthnic populationsStructured interviewsInpatient adolescentsRiskAssociationSuicidality
1989
Corpus callosum dimensions measured by magnetic resonance imaging in bipolar affective disorder and schizophrenia
Hauser P, Dauphinais I, Berrettini W, DeLisi L, Gelernter J, Post R. Corpus callosum dimensions measured by magnetic resonance imaging in bipolar affective disorder and schizophrenia. Biological Psychiatry 1989, 26: 659-668. PMID: 2804188, DOI: 10.1016/0006-3223(89)90100-5.Peer-Reviewed Original ResearchConceptsCerebral areasMagnetic resonance imaging (MRI) brain scansBipolar affective patientsNormal control subjectsBipolar affective disorderControl subjectsCallosal areaPsychiatric illnessCallosal regionsSchizophrenic patientsAffective patientsGender differencesAffective disordersControl groupBrain scansMale subjectsDiagnostic groupsSchizophrenic groupFemale subjectsTesla scannerMidsagittal sliceSignificant differencesPatientsCallosalGenu