2012
The Assembly of Human Complex I
Nouws J, Calvaruso M, Nijtmans L. The Assembly of Human Complex I. 2012, 193-217. DOI: 10.1007/978-94-007-4138-6_10.Peer-Reviewed Original ResearchComplex IHuman mitochondrial complex IComplex I assemblyHuman complex IMitochondrial complex IPrecise molecular mechanismsMitochondrial genomeSpecialized proteinsFunctional enzymeMolecular mechanismsChaperonesAssemblyEnzymeStepwise processDifferent stepsGenomeSubunitsProteinDifferent stagesMembraneComplicated process
2011
Assembly factors as a new class of disease genes for mitochondrial complex I deficiency: cause, pathology and treatment options
Nouws J, Nijtmans L, Smeitink J, Vogel R. Assembly factors as a new class of disease genes for mitochondrial complex I deficiency: cause, pathology and treatment options. Brain 2011, 135: 12-22. PMID: 22036961, DOI: 10.1093/brain/awr261.Peer-Reviewed Original ResearchConceptsComplex I deficiencyAssembly factorsDisease genesI deficiencySpecific assembly factorsGeneral molecular mechanismMitochondrial complex I deficiencyOxidative phosphorylation disordersDisease-causing mutationsSuch genesMolecular mechanismsComplex IGenesLarge diversityProgressive encephalomyopathyChaperonesDiversityMutationsEncephalomyopathyDeficiencyNew class