2022
Longitudinal Outcomes of Subcutaneous or Transvenous Implantable Cardioverter-Defibrillators in Older Patients
Friedman DJ, Qin L, Parzynski C, Heist EK, Russo AM, Ranasinghe I, Zeitler EP, Minges KE, Akar JG, Freeman JV, Curtis JP, Al-Khatib SM. Longitudinal Outcomes of Subcutaneous or Transvenous Implantable Cardioverter-Defibrillators in Older Patients. Journal Of The American College Of Cardiology 2022, 79: 1050-1059. PMID: 35300816, DOI: 10.1016/j.jacc.2021.12.033.Peer-Reviewed Original ResearchConceptsOlder patientsCause readmissionS-ICDNational Cardiovascular Data Registry ICD RegistryDevice removalTransvenous implantable cardioverter defibrillatorTV-ICD patientsRisk of deathS-ICD patientsService Medicare beneficiariesAnderson-Gill modelsImplantable cardioverter defibrillatorRepresentative national cohortCompeting-risks modelTV-ICDCardiovascular readmissionCause mortalityICD implantationYounger patientsICD RegistryNonfatal outcomesTransvenous ICDAtrial fibrillationNational cohortCardioverter defibrillatorTrends in Use of Single- vs Dual-Chamber Implantable Cardioverter-Defibrillators Among Patients Without a Pacing Indication, 2010-2018
Borne RT, Varosy P, Lan Z, Masoudi FA, Curtis JP, Matlock DD, Peterson PN. Trends in Use of Single- vs Dual-Chamber Implantable Cardioverter-Defibrillators Among Patients Without a Pacing Indication, 2010-2018. JAMA Network Open 2022, 5: e223429. PMID: 35315917, PMCID: PMC8941353, DOI: 10.1001/jamanetworkopen.2022.3429.Peer-Reviewed Original ResearchConceptsDual-chamber ICDFirst-time ICD implantationPacing indicationICD implantationMedian odds ratioPatient characteristicsOdds ratioAtrial leadNational Cardiovascular Data Registry ICD RegistryCardiac resynchronization therapy indicationDual-chamber ICD implantationMulticenter cross-sectional studyBradycardia pacing indicationSingle-chamber ICDHospital-level variationHigh procedural riskCross-sectional studyLow-value practicesImplantable cardioverter defibrillatorLow-value careCochran-Armitage trend testImplantable cardioverter-defibrillator systemsDual-chamber devicesCardioverter-defibrillator systemsReal-world practice
2021
Longitudinal Outcomes Associated With Non-Evidence-Based Implantable Cardioverter-Defibrillators Among Medicare Beneficiaries (From the National Cardiovascular Data Registry)
Daimee UA, Aslam F, Parzynski CS, Desai NR, Curtis JP. Longitudinal Outcomes Associated With Non-Evidence-Based Implantable Cardioverter-Defibrillators Among Medicare Beneficiaries (From the National Cardiovascular Data Registry). The American Journal Of Cardiology 2021, 155: 64-71. PMID: 34315569, DOI: 10.1016/j.amjcard.2021.06.020.Peer-Reviewed Original ResearchConceptsPrimary prevention ICD implantationRisk of mortalityICD implantationHeart failureICD RegistryMortality riskNational Cardiovascular Data Registry ICD RegistryPivotal randomized clinical trialsHospital adverse eventsSevere heart failureRecent myocardial infarctionCause hospital readmissionRandomized clinical trialsSimilar mortality riskLongitudinal outcomesImplantable cardioverter defibrillatorGreater mortality riskCause hospitalizationCause mortalityCoronary revascularizationAdverse eventsHospital readmissionICD recipientsDevice implantationPrimary prevention
2020
Trends in Use and In-Hospital Outcomes of Subcutaneous Implantable Cardioverter Defibrillators in Patients Undergoing Long-Term Dialysis
Pun PH, Parzynski CS, Friedman DJ, Sanders G, Curtis JP, Al-Khatib SM. Trends in Use and In-Hospital Outcomes of Subcutaneous Implantable Cardioverter Defibrillators in Patients Undergoing Long-Term Dialysis. Clinical Journal Of The American Society Of Nephrology 2020, 15: 1622-1630. PMID: 32967922, PMCID: PMC7646229, DOI: 10.2215/cjn.07920520.Peer-Reviewed Original ResearchConceptsHospital cardiac arrestSubcutaneous ICDTransvenous ICDICD implantsHospital outcomesICD recipientsICD RegistryCardiac arrestHigh riskNational Cardiovascular Data Registry ICD RegistryFirst-time ICD recipientsPropensity score-weighted analysisImplantable cardioverter defibrillator implantationSubcutaneous implantable cardioverter defibrillatorIn-Hospital OutcomesShort-term complicationsCardioverter-defibrillator implantationLong-term dialysisVascular access siteImplantable cardioverter defibrillatorCause deathHospital complicationsHospital stayDefibrillator implantationUS patients
2019
Modeling defibrillation benefit for survival among cardiac resynchronization therapy defibrillator recipients
Bilchick KC, Wang Y, Curtis JP, Cheng A, Dharmarajan K, Shadman R, Dardas TF, Anand I, Lund LH, Dahlström U, Sartipy U, Maggioni A, O'Connor C, Levy WC. Modeling defibrillation benefit for survival among cardiac resynchronization therapy defibrillator recipients. American Heart Journal 2019, 222: 93-104. PMID: 32032927, PMCID: PMC7814502, DOI: 10.1016/j.ahj.2019.12.017.Peer-Reviewed Original ResearchConceptsCRT-D patientsImplantable cardioverter defibrillatorSurvival benefitCRT-DsCardiac resynchronization therapy defibrillator recipientsCardiac resynchronization therapy candidatesSeattle Heart Failure ModelSeattle Proportional Risk ModelCox proportional hazards regressionNational Cardiovascular Data RegistryHeart Failure TrialHeart failure patientsProportional hazards regressionHeart failure modelProportional risk modelFailure patientsCRT candidatesHeart failureCRT pacemakerFailure TrialArrhythmic deathHazards regressionDefibrillator recipientsCRT deviceCardioverter defibrillatorIMPLANTABLE CARDIOVERTER DEFIBRILLATOR IN PATIENTS WITH NON-ISCHEMIC CARDIOMYOPATHY IN THE UNITED STATES: INSIGHTS FROM THE NCDR ICD REGISTRY, AN NCDR® RESEARCH TO PRACTICE (R2P) PROJECT
Kutyifa V, Bao H, Cha Y, Hsu J, Varosy P, Masoudi F, Curtis J, Peterson P. IMPLANTABLE CARDIOVERTER DEFIBRILLATOR IN PATIENTS WITH NON-ISCHEMIC CARDIOMYOPATHY IN THE UNITED STATES: INSIGHTS FROM THE NCDR ICD REGISTRY, AN NCDR® RESEARCH TO PRACTICE (R2P) PROJECT. Journal Of The American College Of Cardiology 2019, 73: 311. DOI: 10.1016/s0735-1097(19)30919-2.Peer-Reviewed Original ResearchNon-ischemic cardiomyopathyImplantable cardioverter defibrillatorNCDR ICD RegistryICD RegistryCardioverter defibrillatorPractice projectPatientsCardiomyopathyRegistryNCDRDefibrillator
2018
Association of the US Department of Justice Investigation of Implantable Cardioverter-Defibrillators and Devices Not Meeting the Medicare National Coverage Determination, 2007-2015
Desai NR, Bourdillon PM, Parzynski CS, Brindis RG, Spatz ES, Masters C, Minges KE, Peterson P, Masoudi FA, Oetgen WJ, Buxton A, Zipes DP, Curtis JP. Association of the US Department of Justice Investigation of Implantable Cardioverter-Defibrillators and Devices Not Meeting the Medicare National Coverage Determination, 2007-2015. JAMA 2018, 320: 63-71. PMID: 29971398, PMCID: PMC6583049, DOI: 10.1001/jama.2018.8151.Peer-Reviewed Original ResearchConceptsPrimary prevention ICDsNon-Medicare beneficiariesAbsolute decreaseNational Cardiovascular Data Registry ICD RegistrySerial cross-sectional analysisStudy periodImplantable cardioverter defibrillatorRelative decreaseCross-sectional analysisProportion of devicesInitial ICDICD RegistryPrimary preventionCardioverter defibrillatorMAIN OUTCOMEMedicare beneficiariesUS hospitalsHospital groupHospitalICDMore rapid decreasesModest decreaseDepartmentMedicareUS DepartmentVentricular Fibrillation Conversion Testing After Implantation of a Subcutaneous Implantable Cardioverter Defibrillator
Friedman DJ, Parzynski CS, Heist EK, Russo AM, Akar JG, Freeman JV, Curtis JP, Al-Khatib SM. Ventricular Fibrillation Conversion Testing After Implantation of a Subcutaneous Implantable Cardioverter Defibrillator. Circulation 2018, 137: 2463-2477. PMID: 29463509, PMCID: PMC5988932, DOI: 10.1161/circulationaha.117.032167.Peer-Reviewed Original ResearchConceptsImplantable cardioverter defibrillatorS-ICD implantationLogistic regression analysisInhospital complicationsPatient characteristicsCT testingS-ICDsCardioverter defibrillatorConversion testingPrior implantable cardioverter defibrillatorHigher body mass indexMultivariable logistic regression analysisLarger body surface areaSubcutaneous implantable cardioverter defibrillatorTransvenous implantable cardioverter defibrillatorInhospital adverse eventsLow ejection fractionAvailable patient characteristicsBody mass indexBody surface areaFirst-time recipientsMaximum device outputRegression analysisPredictors of useInsufficient safety margin
2017
Complications Associated With Implantable Cardioverter Defibrillators in Adults With Congenital Heart Disease or Left Ventricular Noncompaction Cardiomyopathy (From the NCDR® Implantable Cardioverter-Defibrillator Registry)
Gleva MJ, Wang Y, Curtis JP, Berul CI, Huddleston CB, Poole JE. Complications Associated With Implantable Cardioverter Defibrillators in Adults With Congenital Heart Disease or Left Ventricular Noncompaction Cardiomyopathy (From the NCDR® Implantable Cardioverter-Defibrillator Registry). The American Journal Of Cardiology 2017, 120: 1891-1898. PMID: 28917495, DOI: 10.1016/j.amjcard.2017.07.103.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseComplication rateVentricular noncompaction cardiomyopathyHeart diseaseHospital complicationsEbstein's anomalyCardiac resynchronizationSeptal defectNoncompaction cardiomyopathyImplantable cardioverter defibrillator implantationDual chamberAcute lead dislodgmentsSingle-chamber ICDCardioverter-defibrillator implantationPeriprocedural complication rateGreater complication rateVentricular septal defectTetralogy of FallotAtrial septal defectImplantable cardioverter defibrillatorChildhood heart diseaseSingle-chamber devicesChi-square testHospital deathAdult patientsUse of Cardiac Resynchronization Therapy Among Eligible Patients Receiving an Implantable Cardioverter Defibrillator: Insights From the National Cardiovascular Data Registry Implantable Cardioverter Defibrillator Registry
Marzec LN, Peterson PN, Bao H, Curtis JP, Masoudi FA, Varosy PD, Bradley SM. Use of Cardiac Resynchronization Therapy Among Eligible Patients Receiving an Implantable Cardioverter Defibrillator: Insights From the National Cardiovascular Data Registry Implantable Cardioverter Defibrillator Registry. JAMA Cardiology 2017, 2: 561-565. PMID: 28122073, PMCID: PMC5814986, DOI: 10.1001/jamacardio.2016.5388.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAtrial FibrillationBlack or African AmericanBundle-Branch BlockCardiac Resynchronization TherapyCardiac Resynchronization Therapy DevicesCerebrovascular DisordersCohort StudiesComorbidityDefibrillators, ImplantableDiabetes MellitusEthnicityFemaleHealth Facility SizeHeart FailureHospitalsHospitals, TeachingHumansHypertensionInsurance, HealthLung DiseasesMaleMedicaidMedicareMiddle AgedMortalityMyocardial IschemiaPractice Patterns, Physicians'RegistriesRegression AnalysisRetrospective StudiesUnited StatesWhite PeopleConceptsUse of CRTCardiac resynchronization therapyCRT-D useImplantable cardioverter defibrillatorGuideline-eligible patientsDevice implantationEligible patientsResynchronization therapyCardioverter defibrillatorNational Cardiovascular Data Registry Implantable Cardioverter Defibrillator RegistryNational Cardiovascular Data Registry ICD RegistryHeart failure-related eventsImplantable Cardioverter-Defibrillator RegistryCRT-D groupMulticenter retrospective cohortRisk-standardized ratesHospital-level variationCRT-D devicesHierarchical multivariable modelNonprivate insuranceRetrospective cohortSelect patientsICD RegistryGuideline recommendationsICD placement
2016
Trends and In-Hospital Outcomes Associated With Adoption of the Subcutaneous Implantable Cardioverter Defibrillator in the United States
Friedman DJ, Parzynski CS, Varosy PD, Prutkin JM, Patton KK, Mithani A, Russo AM, Curtis JP, Al-Khatib SM. Trends and In-Hospital Outcomes Associated With Adoption of the Subcutaneous Implantable Cardioverter Defibrillator in the United States. JAMA Cardiology 2016, 1: 900-911. PMID: 27603935, PMCID: PMC5112106, DOI: 10.1001/jamacardio.2016.2782.Peer-Reviewed Original ResearchConceptsSubcutaneous implantable cardioverter defibrillatorPropensity-matched analysisS-ICDHospital outcomesImplantable cardioverter defibrillatorICD implantsComplication rateICD RegistryDFT testingS-ICDsCardioverter defibrillatorNational Cardiovascular Data Registry ICD RegistryHospital complication ratesIn-Hospital OutcomesPrior cardiac arrestLow complication rateS-ICD implantationUse of ICDsSC-ICDICD implantationCardiac arrestMean ageRetrospective analysisMAIN OUTCOMEPatientsAssociation Between a Prolonged PR Interval and Outcomes of Cardiac Resynchronization Therapy
Friedman DJ, Bao H, Spatz ES, Curtis JP, Daubert JP, Al-Khatib SM. Association Between a Prolonged PR Interval and Outcomes of Cardiac Resynchronization Therapy. Circulation 2016, 134: 1617-1628. PMID: 27760795, PMCID: PMC5418126, DOI: 10.1161/circulationaha.116.022913.Peer-Reviewed Original ResearchConceptsHeart failure hospitalizationFailure hospitalizationPR intervalImplantable cardioverter defibrillatorNational Cardiovascular Data Registry ICD RegistryCardiac resynchronization therapy candidatesIncident heart failure hospitalizationReal-world comparative effectivenessCRT-eligible patientsReceipt of CRTChronic kidney diseaseCardiac resynchronization therapyCRT-D patientsCoronary artery diseaseProlonged PR intervalComparative effectiveness analysisMore comorbiditiesArtery diseaseDiabetes mellitusICD recipientsICD RegistryResynchronization therapyAtrial arrhythmiasKidney diseaseCardioverter defibrillator
2015
Use of Remote Monitoring Is Associated With Lower Risk of Adverse Outcomes Among Patients With Implanted Cardiac Defibrillators
Akar JG, Bao H, Jones PW, Wang Y, Varosy PD, Masoudi FA, Stein KM, Saxon LA, Normand SL, Curtis JP. Use of Remote Monitoring Is Associated With Lower Risk of Adverse Outcomes Among Patients With Implanted Cardiac Defibrillators. Circulation Arrhythmia And Electrophysiology 2015, 8: 1173-1180. PMID: 26092577, DOI: 10.1161/circep.114.003030.Peer-Reviewed Original ResearchConceptsImplantable cardioverter defibrillatorInitial implantable cardioverter defibrillatorCause mortalityLower riskAdverse outcomesNational Cardiovascular Data Registry ICD RegistryRemote patient monitoringSocial Security Death Master FileCause rehospitalization rateRisk of rehospitalizationImplanted cardiac defibrillatorsDeath Master FileCardiomyopathy pathogenesisCause rehospitalizationICD RegistryRehospitalization ratesMultivariable analysisStudy cohortVital statusService patientsCardioverter defibrillatorCox modelMedicare populationMedicare feePatientsCardiac Resynchronization Therapy in Women Versus Men
Zusterzeel R, Spatz ES, Curtis JP, Sanders WE, Selzman KA, Piña IL, Bao H, Ponirakis A, Varosy PD, Masoudi FA, Caños DA, Strauss DG. Cardiac Resynchronization Therapy in Women Versus Men. Circulation Cardiovascular Quality And Outcomes 2015, 8: s4-s11. PMID: 25714821, DOI: 10.1161/circoutcomes.114.001548.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBundle-Branch BlockCardiac Resynchronization TherapyCardiac Resynchronization Therapy DevicesDefibrillators, ImplantableElectric CountershockFemaleHealth Status DisparitiesHeart Conduction SystemHeart FailureHumansKaplan-Meier EstimateMalePropensity ScoreProportional Hazards ModelsRegistriesRisk FactorsSex FactorsStroke VolumeTreatment OutcomeUnited StatesVentricular Function, LeftConceptsLeft bundle branch blockQRS durationImplantable cardioverter defibrillatorPatient sexDeath riskCardioverter defibrillatorBetter survivalMortality differencesNew York Heart Association class IIILeft ventricular ejection fractionWomen Versus MenCardiac resynchronization therapyVentricular ejection fractionRelative death riskBenefit of CRTLonger QRS durationShorter QRS durationBundle branch blockLower mortality riskEjection fractionHeart failureResynchronization therapyCardiac resynchronizationBranch blockMortality riskA validated risk model for 1-year mortality after primary prevention implantable cardioverter defibrillator placement
Heidenreich PA, Tsai V, Curtis J, Wang Y, Turakhia MP, Masoudi FA, Varosy PD, Goldstein MK. A validated risk model for 1-year mortality after primary prevention implantable cardioverter defibrillator placement. American Heart Journal 2015, 170: 281-289.e2. PMID: 26299225, DOI: 10.1016/j.ahj.2014.12.013.Peer-Reviewed Original ResearchConceptsOne-year mortalityImplantable cardioverter defibrillatorRisk factorsHeart failurePrimary preventionMortality riskRisk scorePrimary prevention implantable cardioverter-defibrillator placementB-type natriuretic peptide valuesImplantable cardioverter-defibrillator placementCardiovascular Disease RegistryPrimary prevention populationNatriuretic peptide valuesChronic lung diseaseSystolic blood pressureSimilar risk factorsBlood urea nitrogenPg/mLLogistic regression modelsPrevention populationICD therapyICD implantationBlood pressureICD RegistryICD placement
2014
Primary Prevention Implantable Cardioverter-Defibrillators and Survival in Older Women
Zeitler EP, Hellkamp AS, Fonarow GC, Hammill SC, Curtis LH, Hernandez AF, Al-Khalidi HR, Curtis JP, Heidenreich PA, Anstrom KJ, Peterson ED, Mark DB, Hammill BG, Sanders GD, Al-Khatib SM. Primary Prevention Implantable Cardioverter-Defibrillators and Survival in Older Women. JACC Heart Failure 2014, 3: 159-167. PMID: 25543969, PMCID: PMC4461749, DOI: 10.1016/j.jchf.2014.09.006.Peer-Reviewed Original ResearchConceptsPrimary prevention implantable cardioverter defibrillatorsImplantable cardioverter defibrillatorHeart failureCardioverter defibrillatorOlder womenNational Cardiovascular Data Registry ICD RegistryLeft ventricular dysfunctionSignificant survival benefitSurvival of womenYears of ageMedicare claims databaseEligible patientsCause mortalityPrimary endpointVentricular dysfunctionSurvival benefitICD RegistryClaims databaseHeart failure databaseLonger survivalClinical trialsPropensity score methodsPatientsWomenSurvivalIn-Hospital Complications Associated With Reoperations of Implantable Cardioverter Defibrillators
Steckman DA, Varosy PD, Parzynski CS, Masoudi FA, Curtis JP, Sauer WH, Nguyen DT. In-Hospital Complications Associated With Reoperations of Implantable Cardioverter Defibrillators. The American Journal Of Cardiology 2014, 114: 419-426. PMID: 24927972, DOI: 10.1016/j.amjcard.2014.05.010.Peer-Reviewed Original ResearchConceptsHospital complicationsComplication rateRepeat proceduresLead extractionICD proceduresMultivariable adjusted odds ratiosNational Cardiovascular Data RegistryInitial implantImplantable cardioverter-defibrillator (ICD) proceduresHierarchical multivariable logistic regressionHospital adverse eventsAdjusted odds ratioHigh complication rateMultivariable logistic regressionLarge national cohortImplantable cardioverter defibrillatorHospital deathAdverse eventsICD implantationPatient characteristicsNational cohortOdds ratioProcedural outcomesCardioverter defibrillatorHigh risk
2013
Temporal Trends in Quality of Care Among Recipients of Implantable Cardioverter-Defibrillators
Dodson JA, Lampert R, Wang Y, Hammill SC, Varosy P, Curtis JP. Temporal Trends in Quality of Care Among Recipients of Implantable Cardioverter-Defibrillators. Circulation 2013, 129: 580-586. PMID: 24192798, PMCID: PMC3946506, DOI: 10.1161/circulationaha.113.003747.Peer-Reviewed Original ResearchConceptsOptimal medical therapyCardiac resynchronization therapyAdverse eventsEligible patientsQuality of careICD RegistryPotential confoundersNew York Heart Association class III/IVClass III/IVAngiotensin-converting enzyme inhibitorAngiotensin receptor blockersVentricular ejection fractionNew ICD implantsImplantable cardioverter defibrillatorHierarchical logistic regressionCRT eligibilityReceptor blockersEjection fractionMedical therapyResynchronization therapyICD implantsObservational studyCardioverter defibrillatorΒ-blockersPatientsPrevalence, Correlates, and Temporal Trends in Antiarrhythmic Drug Use at Discharge After Implantable Cardioverter Defibrillator Placement (from the National Cardiovascular Data Registry [NCDR])
Dev S, Peterson PN, Wang Y, Curtis JP, Varosy PD, Masoudi FA. Prevalence, Correlates, and Temporal Trends in Antiarrhythmic Drug Use at Discharge After Implantable Cardioverter Defibrillator Placement (from the National Cardiovascular Data Registry [NCDR]). The American Journal Of Cardiology 2013, 113: 314-320. PMID: 24216126, DOI: 10.1016/j.amjcard.2013.09.023.Peer-Reviewed Original ResearchConceptsImplantable cardioverter defibrillatorAntiarrhythmic drug useAntiarrhythmic drugsMedian odds ratioHospital dischargeOdds ratioSecondary prevention implantable cardioverter defibrillatorDrug useClass III antiarrhythmic drugsImplantable cardioverter-defibrillator placementMultivariate logistic regression modelHospital-level variationClass III agentsLocal treatment patternsLogistic regression modelsFacility-level variablesAntiarrhythmic useICD implantationICD recipientsICD RegistryHospital variationICD placementTreatment patternsDevice shocksAntiarrhythmic agentsCardiovascular Care Facts A Report From the National Cardiovascular Data Registry: 2011
Masoudi FA, Ponirakis A, Yeh RW, Maddox TM, Beachy J, Casale PN, Curtis JP, De Lemos J, Fonarow G, Heidenreich P, Koutras C, Kremers M, Messenger J, Moussa I, Oetgen WJ, Roe MT, Rosenfield K, Shields TP, Spertus JA, Wei J, White C, Young CH, Rumsfeld JS. Cardiovascular Care Facts A Report From the National Cardiovascular Data Registry: 2011. Journal Of The American College Of Cardiology 2013, 62: 1931-1947. PMID: 24036027, DOI: 10.1016/j.jacc.2013.05.099.Peer-Reviewed Original ResearchConceptsQuality of careACTION Registry-GWTGCardiovascular diseasePatient outcomesAcute coronary syndromePercutaneous coronary interventionImportant patient outcomesImplantable cardioverter defibrillatorNational registry programMeasure of ProcessesNCDR modelsPINNACLE RegistryCoronary syndromeCarotid revascularizationCathPCI RegistryClinical characteristicsCoronary interventionCare registriesRegistry programLeading causeCardiovascular careCardioverter defibrillatorPatientsRegistryHospital