2014
A reanalysis of cluster randomized trials showed interrupted time-series studies were valuable in health system evaluation
Fretheim A, Zhang F, Ross-Degnan D, Oxman AD, Cheyne H, Foy R, Goodacre S, Herrin J, Kerse N, McKinlay RJ, Wright A, Soumerai SB. A reanalysis of cluster randomized trials showed interrupted time-series studies were valuable in health system evaluation. Journal Of Clinical Epidemiology 2014, 68: 324-333. PMID: 25499983, DOI: 10.1016/j.jclinepi.2014.10.003.Peer-Reviewed Original ResearchConceptsC-RCTsControl groupInterrupted time series studyConfidence intervalsConcurrent control groupHealth system interventionsHealth system evaluationControl arm dataInterrupted time series designIntervention armRandomized trialsControl group dataTrial dataTime-series studyTime series designHealth systemStudy designEffect estimatesTrialsInterventionSystem interventionsArm dataGroup dataRCTsGroupStereotactic Body Radiation Therapy Versus Intensity-Modulated Radiation Therapy for Prostate Cancer: Comparison of Toxicity
Yu JB, Cramer LD, Herrin J, Soulos PR, Potosky AL, Gross CP. Stereotactic Body Radiation Therapy Versus Intensity-Modulated Radiation Therapy for Prostate Cancer: Comparison of Toxicity. Journal Of Clinical Oncology 2014, 32: 1195-1201. PMID: 24616315, PMCID: PMC3986382, DOI: 10.1200/jco.2013.53.8652.Peer-Reviewed Original ResearchConceptsStereotactic body radiation therapyIntensity-modulated radiation therapyGU toxicityIMRT patientsRadiation therapyTreatment initiationProstate cancerTreatment costsSBRT patientsMedicare beneficiaries ageBody radiation therapyMean treatment costProstate cancer treatmentRandom-effects modelUrinary incontinenceBiologic doseRandomized trialsRetrospective studyPrimary treatmentLower treatment costsBeneficiaries agePatientsMedicare programRadiation therapy treatmentProspective correlation
2010
The Effect of How Outcomes Are Framed on Decisions about Whether to Take Antihypertensive Medication: A Randomized Trial
Carling CL, Kristoffersen DT, Oxman AD, Flottorp S, Fretheim A, Schünemann HJ, Akl EA, Herrin J, MacKenzie TD, Montori VM. The Effect of How Outcomes Are Framed on Decisions about Whether to Take Antihypertensive Medication: A Randomized Trial. PLOS ONE 2010, 5: e9469. PMID: 20209127, PMCID: PMC2830888, DOI: 10.1371/journal.pone.0009469.Peer-Reviewed Original ResearchConceptsAntihypertensive medicationsVisual analog scaleCardiovascular diseaseVAS scoresRelative importance scoresCVD risk reductionYear old manLow baseline riskDetailed patient informationRandomized trialsAnalog scaleRisk factorsBaseline riskMedicationsAdult volunteersHypertensionLogistic regressionPatient informationSignificant decreaseTrialsSignificant differencesRisk reductionPresentationParticipantsRisk
2009
The Effect of Alternative Graphical Displays Used to Present the Benefits of Antibiotics for Sore Throat on Decisions about Whether to Seek Treatment: A Randomized Trial
Carling CL, Kristoffersen DT, Flottorp S, Fretheim A, Oxman AD, Schünemann HJ, Akl EA, Herrin J, MacKenzie TD, Montori VM. The Effect of Alternative Graphical Displays Used to Present the Benefits of Antibiotics for Sore Throat on Decisions about Whether to Seek Treatment: A Randomized Trial. PLOS Medicine 2009, 6: e1000140. PMID: 19707579, PMCID: PMC2726763, DOI: 10.1371/journal.pmed.1000140.Peer-Reviewed Original ResearchConceptsSore throatVisual analog scaleBenefits of antibioticsVAS scoresRelative importance scoresDay threeDuration of symptomsTreatment effectsConsequence of treatmentProportion of peopleDetailed patient informationAntibiotic prescriptionsSymptom reliefRandomized trialsAnalog scaleAdult volunteersHealth programsSymptomsLogistic regressionAverage durationPatient informationMost participantsTrialsAntibioticsSignificant differences