2013
Alleles of a Polymorphic ETV6 Binding Site in DCDC2 Confer Risk of Reading and Language Impairment
Powers NR, Eicher JD, Butter F, Kong Y, Miller LL, Ring SM, Mann M, Gruen JR. Alleles of a Polymorphic ETV6 Binding Site in DCDC2 Confer Risk of Reading and Language Impairment. American Journal Of Human Genetics 2013, 93: 19-28. PMID: 23746548, PMCID: PMC3710765, DOI: 10.1016/j.ajhg.2013.05.008.Peer-Reviewed Original ResearchMeSH KeywordsAllelesBase SequenceBinding SitesCase-Control StudiesDyslexiaGenetic Association StudiesHaplotypesHeLa CellsHumansLanguage Development DisordersLanguage TestsLinkage DisequilibriumMicrosatellite RepeatsMicrotubule-Associated ProteinsMolecular Sequence DataPhylogenyPolymorphism, GeneticPromoter Regions, GeneticProtein BindingProto-Oncogene Proteins c-etsRepressor ProteinsRisk Factors
1999
Cloning of a Novel MHC-Encoded Serine Peptidase Highly Expressed by Cortical Epithelial Cells of the Thymus
Bowlus C, Ahn J, Chu T, Gruen J. Cloning of a Novel MHC-Encoded Serine Peptidase Highly Expressed by Cortical Epithelial Cells of the Thymus. Cellular Immunology 1999, 196: 80-86. PMID: 10527559, DOI: 10.1006/cimm.1999.1543.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntigen PresentationAntigens, Differentiation, B-LymphocyteBase SequenceCarboxypeptidasesConsensus SequenceCosmidsEpithelial CellsFluorescent Antibody Technique, IndirectGenesHistocompatibility Antigens Class IIHumansIn Situ HybridizationLysosomesMajor Histocompatibility ComplexMiceMice, Inbred C57BLMolecular Sequence DataSequence AlignmentSequence Homology, Amino AcidSerine EndopeptidasesThymus GlandConceptsCortical thymic epithelial cellsAntigen-presenting cellsThymic epithelial cellsEpithelial cellsMHC class II presentationClass II antigen processingMHC class II antigen processingClass II presentationCortical epithelial cellsMajor histocompatibility complex regionThymic capsuleThymic cortexAntigen presentationT cellsSerine proteasesStrong stainingNovel MHCAntigen processingInvariant chainCathepsin SProteolytic milieuThymusPresentationSitu hybridizationStainingThe genomic organization of the histone clusters on human 6p21.3
Ahn J, Gruen J. The genomic organization of the histone clusters on human 6p21.3. Mammalian Genome 1999, 10: 768-770. PMID: 10384058, DOI: 10.1007/s003359901089.Peer-Reviewed Original Research
1995
Cloning of a New "Finger" Protein Gene (ZNF173) within the Class I Region of the Human MHC
Chu T, Capossela A, Coleman R, Goei V, Nallur G, Gruen J. Cloning of a New "Finger" Protein Gene (ZNF173) within the Class I Region of the Human MHC. Genomics 1995, 29: 229-239. PMID: 8530076, DOI: 10.1006/geno.1995.1236.Peer-Reviewed Original ResearchMeSH KeywordsAlpha-FetoproteinsAmino Acid SequenceAnimalsBase SequenceCloning, MolecularConsensus SequenceConserved SequenceDNA, ComplementaryDNA-Binding ProteinsGene LibraryGenes, MHC Class IHominidaeHumansKidneyMajor Histocompatibility ComplexMiceMolecular Sequence DataRestriction MappingSequence Homology, Amino AcidZinc FingersConceptsFull-length cDNA cloneClass I regionHuman coding regionsPartial genomic cloneHuman MHCConceptual proteinFinger proteinGenomic clonesPositional cloningCDNA clonesCDNA sequenceProtein genePolyglutamic acid regionCarboxyl terminusI regionBiological roleCoding regionsAcid regionRelated sequencesGenesMultiple tissuesProteinMajor histocompatability complexCloningNucleic acids
1991
Differential expression of novel Gsα signal transduction protein cDNA species
Swaroop A, Agarwal N, Gruen J, Bick D, Weissman S. Differential expression of novel Gsα signal transduction protein cDNA species. Nucleic Acids Research 1991, 19: 4725-4729. PMID: 1716359, PMCID: PMC328715, DOI: 10.1093/nar/19.17.4725.Peer-Reviewed Original ResearchConceptsCDNA speciesAlpha speciesDifferential expressionSignal transduction proteinsAlpha cDNA cloneTransduction proteinsHeterotrimeric complexCDNA clonesAlternative promotersNovel exonsAlternate splicingAUG codonHuman adult retinaMembrane receptorsGs alphaNovel signalSpeciesSpecific oligonucleotide probesOligonucleotide probesSitu hybridizationExon 2Total RNASpecific primersMolecular heterogeneityAdult retina