1999
Cloning of a Novel MHC-Encoded Serine Peptidase Highly Expressed by Cortical Epithelial Cells of the Thymus
Bowlus C, Ahn J, Chu T, Gruen J. Cloning of a Novel MHC-Encoded Serine Peptidase Highly Expressed by Cortical Epithelial Cells of the Thymus. Cellular Immunology 1999, 196: 80-86. PMID: 10527559, DOI: 10.1006/cimm.1999.1543.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntigen PresentationAntigens, Differentiation, B-LymphocyteBase SequenceCarboxypeptidasesConsensus SequenceCosmidsEpithelial CellsFluorescent Antibody Technique, IndirectGenesHistocompatibility Antigens Class IIHumansIn Situ HybridizationLysosomesMajor Histocompatibility ComplexMiceMice, Inbred C57BLMolecular Sequence DataSequence AlignmentSequence Homology, Amino AcidSerine EndopeptidasesThymus GlandConceptsCortical thymic epithelial cellsAntigen-presenting cellsThymic epithelial cellsEpithelial cellsMHC class II presentationClass II antigen processingMHC class II antigen processingClass II presentationCortical epithelial cellsMajor histocompatibility complex regionThymic capsuleThymic cortexAntigen presentationT cellsSerine proteasesStrong stainingNovel MHCAntigen processingInvariant chainCathepsin SProteolytic milieuThymusPresentationSitu hybridizationStaining
1992
Physical and genetic mapping of the telomeric major histocompatibility complex region in man and relevance to the primary hemochromatosis gene (HFE)
Gruen J, Goei V, Summers K, Capossela A, Powell L, Halliday J, Zoghbi H, Shukla H, Weissman S. Physical and genetic mapping of the telomeric major histocompatibility complex region in man and relevance to the primary hemochromatosis gene (HFE). Genomics 1992, 14: 232-240. PMID: 1427838, DOI: 10.1016/s0888-7543(05)80211-3.Peer-Reviewed Original ResearchConceptsPhysical mapGenomic DNACell linesRadiation hybrid cell linesHigh-resolution physical mapLong-range physical mapGenetic mapping studiesHuman genomic DNAPulsed-field gel electrophoresisHybrid cell linesRestriction fragment banding patternsMajor histocompatibility complex regionGenetic mappingMajor histocompatibility complex (MHC) class I regionHuman genomeHLA-F geneBanding patternsClass I regionGenesDisequilibrium analysisGel electrophoresisMapping studiesDNAI regionClass I