2001
Peaks of Linkage Are Localized by a BAC/PAC Contig of the 6p Reading Disability Locus
Ahn J, Won T, Zia A, Reutter H, Kaplan D, Sparks R, Gruen J. Peaks of Linkage Are Localized by a BAC/PAC Contig of the 6p Reading Disability Locus. Genomics 2001, 78: 19-29. PMID: 11707069, DOI: 10.1006/geno.2001.6645.Peer-Reviewed Original ResearchConceptsBacterial artificial chromosomeBAC/PAC contigHigh-resolution genetic studiesEntire chromosome 6Intermarker distanceArtificial chromosome contigPhysical mapping dataPeak of linkageSuccinic semialdehyde dehydrogenaseUncharacterized genesGenetic boundariesSequence tagsShort tandem repeatsArtificial chromosomesMarker orderClone contigNew contigPhysical mapGenetic lociLinkage peakCandidate genesPAC contigSemialdehyde dehydrogenaseContigsChromosome 6Human GABAB receptor 1 gene: Eight novel sequence variants
Hisama F, Gruen J, Choi J, Huseinovic M, Grigorenko E, Pauls D, Mattson R, Gelernter J, Wood F, Goei V. Human GABAB receptor 1 gene: Eight novel sequence variants. Human Mutation 2001, 17: 349-350. PMID: 11295833, DOI: 10.1002/humu.34.Peer-Reviewed Original ResearchMeSH KeywordsChromosome MappingChromosomes, Human, Pair 6DNA Mutational AnalysisDNA PrimersExonsGene FrequencyGenetic Predisposition to DiseaseGenetic VariationHumansIntronsMental DisordersMutationMutation, MissensePolymorphism, GeneticPolymorphism, Restriction Fragment LengthPolymorphism, Single-Stranded ConformationalReceptors, GABA-BUnited StatesConceptsNeurobehavioral disordersPrincipal inhibitory neurotransmitterHuman leukocyte antigen (HLA) regionInhibitory neurotransmitterPharmacogenetic studiesGene mutationsAntigen regionIntron variantsMissense mutationsDistinct mutationsDisordersLinkage studiesReceptor mapsAmerican populationGABBR1MutationsSusceptibility regionsEpilepsyCandidate genesDNA variantsGABANeurotransmittersSchizophreniaBrain
2000
Identification of polymorphisms in the GABAB receptor gene and linkage study of attention‐deficit hyperactivity disorder
Barr C, Feng Y, Wigg K, Roberts W, Malone M, Schachar R, Tannock R, Gruen J, Goei V, Kennedy J. Identification of polymorphisms in the GABAB receptor gene and linkage study of attention‐deficit hyperactivity disorder. International Journal Of Genomics 2000, 1: 194-201. DOI: 10.1002/1438-826x(200012)1:5/6<194::aid-gnfd194>3.0.co;2-2.Peer-Reviewed Original ResearchDNA sequence variantsReceptor geneInteresting candidate genesIdentification of polymorphismsChromosome locationDNA sequencesCandidate genesReceptor 1 geneGenetic linkageGenetic relationshipsLinkage analysisSequence variantsGenesGABAB receptor geneChromosome 6pCommon variantsHuman leukocyte antigen (HLA) regionLinkage studiesComorbid reading disabilitiesAntigen regionPhenotypeGenetic linkNumber of neurotransmittersReceptorsRole