2014
Reticuloendothelial Saturation Dictates the Development of RBC Resistance to Antibody-Mediated Clearance Following Incompatible Transfusion
Arthur C, Mener A, Patel S, Rodrigues L, Xue C, Nickel R, Zimring J, Hendrickson J, Stowell S. Reticuloendothelial Saturation Dictates the Development of RBC Resistance to Antibody-Mediated Clearance Following Incompatible Transfusion. Blood 2014, 124: 1559. DOI: 10.1182/blood.v124.21.1559.1559.Peer-Reviewed Original ResearchIncompatible RBC transfusionRed blood cellsRBC transfusionInitial transfusionRBC clearanceAntigen modulationOld red blood cellsAntibody-mediated removalFlow cytometric analysisHOD antigenIncompatible transfusionsDetectable antigenRBC ageReticuloendothelial systemCytometric analysisPreferential clearanceAntibody-Mediated ClearanceRBC-specific antibodiesAntibody-opsonized cellsPhagocytic removalTransfused cellsC57BL/6 recipientsAntigen levelsFVB miceRecipient mice
2012
Cellular Protection Against Antibodies Occurs Through a Complement-Independent Pathway
Stowell S, Liepkalns J, Hendrickson J, Pierce K, Smith N, Zimring J. Cellular Protection Against Antibodies Occurs Through a Complement-Independent Pathway. Blood 2012, 120: 3290. DOI: 10.1182/blood.v120.21.3290.3290.Peer-Reviewed Original ResearchHOD RBCsKO miceSurface C3Nonimmunized miceAntigen levelsT cellsAntibody-reactive antigensC3 KO miceComplement inhibitory factorsAutoimmune hemolytic anemiaCell-mediated destructionAntibody-mediated destructionComplement-dependent mechanismAntibody-mediated processComplement-independent pathwaysComplement-independent mechanismsAntibody-secreting cellsNonimmunized control miceComplement degradation productsAntibody engagementCellular protectionCellular resistanceHOD antigenSubsequent transfusionsAntibody levels
2011
Central T Cell Tolerance and Peripheral B Cell Tolerance for An RBC Autoantigen Are Incomplete in Healthy Mice; Implications for AIHA Pathogenesis
Hudson K, Hendrickson J, Cadwell C, Iwakoshi N, Zimring J. Central T Cell Tolerance and Peripheral B Cell Tolerance for An RBC Autoantigen Are Incomplete in Healthy Mice; Implications for AIHA Pathogenesis. Blood 2011, 118: 693. DOI: 10.1182/blood.v118.21.693.693.Peer-Reviewed Original ResearchAutoimmune hemolytic anemiaT cell toleranceOVA/CFAB cell tolerancePathogenesis of AIHAReactive T cellsT cellsHOD antigenAdoptive transferPeripheral toleranceCell toleranceB cellsB6 miceHen egg lysozymeHOD RBCsReactive CD4Humoral toleranceF1 miceImmune responseAntigen expressionTransgenic miceWild-type B6 miceWild-type C57BL/6 micePeripheral B cell toleranceOT-II CD4