TopicNet: a framework for measuring transcriptional regulatory network change
Lou S, Li T, Kong X, Zhang J, Liu J, Lee D, Gerstein M. TopicNet: a framework for measuring transcriptional regulatory network change. Bioinformatics 2020, 36: i474-i481. PMID: 32657410, PMCID: PMC7355251, DOI: 10.1093/bioinformatics/btaa403.Peer-Reviewed Original ResearchConceptsRegulatory network changesTranscription factorsCellular statesDifferent regulatory programsCollection of genesDifferent cellular statesParticular cellular stateParticular transcription factorsRegulatory network connectivityKey transcription factorGene expression dataChromatin immunoprecipitationRegulatory networksCell statesExpression dataRegulatory programsHuman cellsDifferential survivalDiverse groupSupplementary dataDynamic changesLoss of targetImmunoprecipitationGenesActivity differences