2023
Associations of Biomarkers of Kidney Tubule Health, Injury, and Inflammation with Left Ventricular Hypertrophy in Children with CKD
Jiang K, Greenberg J, Abraham A, Xu Y, Schelling J, Feldman H, Schrauben S, Waikar S, Shlipak M, Wettersten N, Coca S, Vasan R, Gutierrez O, Ix J, Warady B, Kimmel P, Bonventre J, Parikh C, Mitsnefes M, Denburg M, Furth S, Ramachandran V, Schelling J, Denburg M, Furth S, Warady B, Bonventre J, Waikar S, Sabbisetti V, Coresh J, Grams M, Rebholz C, Abraham A, Parikh C, Coca S, Rhee E, Kimmel P, Kusek J, Rovin B, Shlipak M, Sarnak M, Gutiérrez O, Ix J, Dubin R, Hostetter T, Deo R, Feldman H, Xie D, Shou H, Ballard S, Whitehead K, Collins H, Greenberg J, Ganz P. Associations of Biomarkers of Kidney Tubule Health, Injury, and Inflammation with Left Ventricular Hypertrophy in Children with CKD. Kidney360 2023, 4: 1039-1047. PMID: 37303083, PMCID: PMC10476681, DOI: 10.34067/kid.0000000000000183.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersChildHumansHypertrophy, Left VentricularInflammationKidney TubulesRenal Insufficiency, ChronicConceptsKidney injury molecule-1Left ventricular hypertrophyUrine KIM-1Injury molecule-1Chemoattractant protein-1Ventricular hypertrophyAlpha-1-microglobulinHigher plasmaLVH prevalenceHigh prevalenceMolecule-1Urine kidney injury molecule-1Urine monocyte chemoattractant protein-1Soluble urokinase-type plasminogen activator receptorTumor necrosis factor receptor 2Monocyte chemoattractant protein-1Kidney tubule healthNecrosis factor receptor 2Pathophysiology of LVHUrine MCP-1Multivariable-adjusted modelsMCP-1 concentrationsBody mass indexProtein 1Child Cohort StudyAssociation of Kidney Tubule Biomarkers With Cardiac Structure and Function in the Multiethnic Study of Atherosclerosis
Wettersten N, Katz R, Greenberg J, Gutierrez O, Lima J, Sarnak M, Schrauben S, Deo R, Bonventre J, Vasan R, Kimmel P, Shlipak M, Ix J. Association of Kidney Tubule Biomarkers With Cardiac Structure and Function in the Multiethnic Study of Atherosclerosis. The American Journal Of Cardiology 2023, 196: 11-18. PMID: 37086700, PMCID: PMC10204591, DOI: 10.1016/j.amjcard.2023.02.031.Peer-Reviewed Original ResearchConceptsPlasma soluble urokinase plasminogen activator receptorSoluble urokinase plasminogen activator receptorKidney tubule injuryCardiac structural abnormalitiesUrokinase plasminogen activator receptorCardiovascular diseasePlasminogen activator receptorLower LVEFTubule injurySystemic inflammationVentricular mass/volume ratioStructural abnormalitiesChitinase-3-like protein 1Activator receptorTwofold greater concentrationCardiac magnetic resonance imagingKidney tubule healthChronic kidney diseaseIncident cardiovascular diseaseGlomerular filtration rateVentricular ejection fractionProtein 1Chemoattractant protein-1Multi-Ethnic StudyAlpha-1-microglobulin
2021
Urine Biomarkers of Kidney Tubule Health, Injury, and Inflammation are Associated with Progression of CKD in Children
Greenberg JH, Abraham AG, Xu Y, Schelling JR, Feldman HI, Sabbisetti VS, Ix JH, Jogalekar MP, Coca S, Waikar SS, Shlipak MG, Warady BA, Vasan RS, Kimmel PL, Bonventre JV, Denburg M, Parikh CR, Furth S, Consortium O. Urine Biomarkers of Kidney Tubule Health, Injury, and Inflammation are Associated with Progression of CKD in Children. Journal Of The American Society Of Nephrology 2021, 32: 2664-2677. PMID: 34544821, PMCID: PMC8722795, DOI: 10.1681/asn.2021010094.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlbuminuriaAlpha-GlobulinsBiomarkersChemokine CCL2ChildChitinase-3-Like Protein 1CreatinineDisease ProgressionEpidermal Growth FactorFemaleFollow-Up StudiesGlomerular Filtration RateHepatitis A Virus Cellular Receptor 1HumansKidney TubulesMaleNephritisProspective StudiesRenal Insufficiency, ChronicConceptsUrine KIM-1CKD progressionUrine biomarkersMicroglobulin concentrationsHighest quartileKIM-1MCP-1High riskRapid kidney function declineBiomarker concentrationsEGF concentrationsKidney tubule healthNovel urine biomarkersUrine biomarker concentrationsKidney function declineProgression of CKDUrine creatinine concentrationIdentification of childrenTubular healthMultivariable adjustmentComposite outcomeTubular injuryPrimary outcomeFunction declineStudy enrollment