2022
Reversibility of brain glucose kinetics in type 2 diabetes mellitus
Sanchez-Rangel E, Gunawan F, Jiang L, Savoye M, Dai F, Coppoli A, Rothman DL, Mason GF, Hwang JJ. Reversibility of brain glucose kinetics in type 2 diabetes mellitus. Diabetologia 2022, 65: 895-905. PMID: 35247067, PMCID: PMC8960594, DOI: 10.1007/s00125-022-05664-y.Peer-Reviewed Original ResearchConceptsType 2 diabetesBrain glucose levelsGlucose levelsHyperglycaemic clampGlycaemic controlBrain glucoseUncontrolled type 2 diabetesType 2 diabetes mellitusConclusions/interpretationThese findingsAims/hypothesisWePlasma glucose levelsLinear mixed-effects regression modelsMixed-effects regression modelsContinuous glucose monitoringMinimal weight changeMagnitude of improvementAge 44.8MethodsEight individualsSD HbA1cDiabetes mellitusCerebral glucoseInterpretationThese findingsWeek interventionRegimen intensificationPost intervention
2017
Blunted rise in brain glucose levels during hyperglycemia in adults with obesity and T2DM
Hwang JJ, Jiang L, Hamza M, Rangel E, Dai F, Belfort-DeAguiar R, Parikh L, Koo BB, Rothman DL, Mason G, Sherwin RS. Blunted rise in brain glucose levels during hyperglycemia in adults with obesity and T2DM. JCI Insight 2017, 2: e95913. PMID: 29046482, PMCID: PMC5846903, DOI: 10.1172/jci.insight.95913.Peer-Reviewed Original ResearchConceptsGlucose levelsPlasma free fatty acid levelsSimilar plasma glucose levelsFree fatty acid levelsCerebral glucose metabolismPlasma glucose levelsBrain glucose levelsFatty acid levelsAltered feeding behaviorGlucose incrementHyperglycemic clampBrain glucoseCerebral functionLean participantsOccipital lobeRodent modelsGlucose metabolismObesityT2DMGlucose responseHyperglycemiaNeurocognitive consequencesSimilar findingsAcid levelsIntracerebral glucose
2015
Fructose Levels Are Markedly Elevated in Cerebrospinal Fluid Compared to Plasma in Pregnant Women
Hwang JJ, Johnson A, Cline G, Belfort-DeAguiar R, Snegovskikh D, Khokhar B, Han CS, Sherwin RS. Fructose Levels Are Markedly Elevated in Cerebrospinal Fluid Compared to Plasma in Pregnant Women. PLOS ONE 2015, 10: e0128582. PMID: 26035307, PMCID: PMC4452737, DOI: 10.1371/journal.pone.0128582.Peer-Reviewed Original ResearchConceptsCerebrospinal fluidPregnant womenSorbitol levelsCSF glucoseGlucose levelsCord blood glucoseVenous cord bloodElective cesarean sectionHuman brainBlood-brain barrierPlasma glucose levelsEffects of fructoseCesarean sectionSpinal anesthesiaPlasma levelsBlood glucoseCord bloodObservational studyDietary consumptionPlasma fructoseMaternal plasmaPolyol pathwayBrainDifferential effectsFructose levels