2001
Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP‐treated monkeys: Feasibility relevant to multiple‐target grafting as a therapy for Parkinson's disease
Collier TJ, Sortwell CE, Elsworth JD, Taylor JR, Roth RH, Sladek JR, Redmond DE. Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP‐treated monkeys: Feasibility relevant to multiple‐target grafting as a therapy for Parkinson's disease. The Journal Of Comparative Neurology 2001, 442: 320-330. PMID: 11793337, DOI: 10.1002/cne.10108.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsBrain Tissue TransplantationCell DifferentiationChlorocebus aethiopsDopamineGraft SurvivalHomovanillic AcidImmunohistochemistryMaleNeostriatumNerve RegenerationNeuritesNeuronsParkinsonian DisordersRecovery of FunctionStem Cell TransplantationStem CellsSubstantia NigraTreatment OutcomeTyrosine 3-MonooxygenaseConceptsSubstantia nigraParkinson's diseaseDA neuronsVentral mesencephalonTyrosine hydroxylaseTH-positive fiber densityEmbryonic DA neuronsEmbryonic dopamine neuronsRostral substantia nigraStriatal DA depletionVentral mesencephalic graftsBasal ganglia circuitryBasal ganglia structuresSuboptimal therapeutic outcomesAfrican green monkeysDA modulationGrafted neuronsVM graftsMesencephalic graftsParkinsonian monkeysSN neuronsDA depletionReplacement therapyDA replacementDA levelsNeurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal
Akbarian S, Bates B, Liu R, Skirboll S, Pejchal T, Coppola V, Sun L, Fan G, Kucera J, Wilson M, Tessarollo L, Kosofsky B, Taylor J, Bothwell M, Nestler E, Aghajanian G, Jaenisch R. Neurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal. Molecular Psychiatry 2001, 6: 593-604. PMID: 11526474, DOI: 10.1038/sj.mp.4000897.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAvoidance LearningBrainColforsinCyclic AMPElectric StimulationEnkephalin, Ala(2)-MePhe(4)-Gly(5)-Gene Expression Regulation, EnzymologicIn Vitro TechniquesIntermediate Filament ProteinsLocus CoeruleusMiceMice, KnockoutMice, TransgenicMorphineMorphine DependenceNerve Tissue ProteinsNestinNeuronsNeurotrophin 3Signal TransductionSubstance Withdrawal SyndromeTyrosine 3-MonooxygenaseConceptsNoradrenergic neuronsNeurotrophin-3NT-3Opiate withdrawalNoradrenergic signalingOpiate withdrawal symptomsChronic morphine exposureNT-3 expressionNon-catecholaminergic neuronsLoss of neuronsDorsal medullaMorphine exposureWithdrawal symptomsAfferent sourcesTyrosine hydroxylaseAdult brainSomatic symptomsNeuron functionVentral forebrainConditional ablationReduced upregulationNeuronsAltered cAMPSymptomsWithdrawal
1998
In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector
During M, Samulski R, Elsworth J, Kaplitt M, Leone P, Xiao X, Li J, Freese A, Taylor J, Roth R, Sladek J, O’Malley K, Redmond D. In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector. Gene Therapy 1998, 5: 820-827. PMID: 9747462, DOI: 10.1038/sj.gt.3300650.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsAromatic-L-Amino-Acid DecarboxylasesChlorocebus aethiopsDependovirusDopamineDopamine AgentsGene ExpressionGene Transfer TechniquesGenetic VectorsHumansImmunohistochemistryMaleParkinson DiseaseTrigeminal Caudal NucleusTyrosine 3-MonooxygenaseConceptsTyrosine hydroxylaseStriatal cellsDopamine-depleted monkeysAdeno-associated virus vectorProduction of dopamineParkinsonian monkeysTransient feverSevere hyperactivityStriatal dopaminePrimate neuronsStereotactic injectionHistological evidencePrimate modelInjection tractNeurotoxin MPTPDopamine productionParkinson's diseaseTreatment groupsSignificant toxicityBehavioral effectsVivo gene therapyElevated levelsBiochemical effectsFirst dayMonkeysPattern of synaptophysin immunoreactivity within mesencephalic grafts following transplantation in a parkinsonian primate model
Sortwell C, Blanchard B, Collier T, Elsworth J, Taylor J, Roth R, Redmond D, Sladek J. Pattern of synaptophysin immunoreactivity within mesencephalic grafts following transplantation in a parkinsonian primate model. Brain Research 1998, 791: 117-124. PMID: 9593853, DOI: 10.1016/s0006-8993(98)00086-9.Peer-Reviewed Original ResearchConceptsGraft-host interactionsMesencephalic graftsFunctional synapsesTyrosine hydroxylaseCerebellar tissuePericellular arraysEmbryonic cerebellar tissueEmbryonic ventral mesencephalonGrafted dopamine neuronsNerve terminal differentiationTH-positive neuronsStriatum of MPTPEnzyme tyrosine hydroxylaseSynthetic enzyme tyrosine hydroxylaseAfrican green monkeysNeurochemical subtypesStriatal portionDA neuronsSynaptophysin immunoreactivityVentral mesencephalonGraft typeDopamine neuronsPrimate modelStriatal targetsSynaptic remodeling