1994
Effects of protein kinase C and cytosolic Ca2+ on exocytosis in the isolated perfused rat liver
Bruck R, Nathanson M, Roelofsen H, Boyer J. Effects of protein kinase C and cytosolic Ca2+ on exocytosis in the isolated perfused rat liver. Hepatology 1994, 20: 1032-1040. PMID: 7927205, DOI: 10.1002/hep.1840200436.Peer-Reviewed Original ResearchConceptsProtein kinase CKinase CApical exocytosisRegulation of exocytosisProtein kinase C inhibitor HHorseradish peroxidase concentrationCytosolic Ca2ExocytosisCell typesInhibitor HProtein kinase C activator phorbol dibutyrateHorseradish peroxidase excretionPhorbol dibutyrateCa2Rat liverRelative importanceNet excretionPeroxidase concentrationsHepatocytes
1993
Intracellular alkalinization stimulates bile flow and vesicular-mediated exocytosis in IPRL
Bruck R, Benedetti A, Strazzabosco M, Boyer J. Intracellular alkalinization stimulates bile flow and vesicular-mediated exocytosis in IPRL. American Journal Of Physiology 1993, 265: g347-g353. PMID: 8368316, DOI: 10.1152/ajpgi.1993.265.2.g347.Peer-Reviewed Original ResearchMeSH Keywords4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAlkaliesAnimalsAnionsBariumBicarbonatesBileBiological TransportColchicineExocytosisHorseradish PeroxidaseHydrogen-Ion ConcentrationIn Vitro TechniquesIntracellular MembranesLiverMalePotassium ChannelsRatsRats, Sprague-DawleyConceptsBiliary HCO3- excretionBile flowHCO3- excretionIntracellular alkalinizationHCO3- exchangerAcute alkaline loadVesicle-mediated exocytosisBiliary excretionTransient increasePH recoveryAlkaline loadMembrane depolarizationRat liverChannel blocker BaCl2Intact liverLiverAlkalinizationMM NH4ClHCO3- concentrationDisulfonic acidDIDSRat hepatocytesColchicinePretreatmentExocytosis
1992
Papaverine inhibits transcytotic vesicle transport and lipid excretion into bile in isolated perfused rat liver
Hayakawa T, Katagiri K, Hoshino M, Nakai T, Ohiwa T, Kumai T, Miyaji M, Takeuchi T, Corasanti J, Boyer J. Papaverine inhibits transcytotic vesicle transport and lipid excretion into bile in isolated perfused rat liver. Hepatology 1992, 16: 1036-1042. PMID: 1398483, DOI: 10.1002/hep.1840160429.Peer-Reviewed Original ResearchConceptsSodium taurocholate infusionBiliary excretionTaurocholate infusionPhosphodiesterase inhibitorBile acidsNonspecific smooth muscle relaxantSmooth muscle relaxantRat liver modelRat liverLipid excretionContinuous infusionBile flowMuscle relaxantsPapaverine inhibitsConstant infusionHorseradish peroxidaseInfusionPapaverineExcretionInhibitory effectCyclic GMPBileLiverLiver modelCyclic AMPRegulatory volume decrease stimulates bile flow, bile acid excretion, and exocytosis in isolated perfused rat liver
Bruck R, Haddad P, Graf J, Boyer J. Regulatory volume decrease stimulates bile flow, bile acid excretion, and exocytosis in isolated perfused rat liver. American Journal Of Physiology 1992, 262: g806-g812. PMID: 1590390, DOI: 10.1152/ajpgi.1992.262.5.g806.Peer-Reviewed Original Research
1990
DBcAMP stimulates vesicle transport and HRP excretion in isolated perfused rat liver
Hayakawa T, Bruck R, Ng O, Boyer J. DBcAMP stimulates vesicle transport and HRP excretion in isolated perfused rat liver. American Journal Of Physiology 1990, 259: g727-g735. PMID: 2173414, DOI: 10.1152/ajpgi.1990.259.5.g727.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBileBile Acids and SaltsBucladesineCells, CulturedGallbladderHorseradish PeroxidaseIn Vitro TechniquesKineticsLiverMalePerfusionRatsRats, Inbred StrainsConceptsBiliary excretionBile acidsBile acid excretionLiver 1Effects of adenosineRat liverElectron microscopic morphometric analysisTranscytotic vesicle pathwayLate peakHRP excretionHorseradish peroxidaseMin infusionBile flowExcretory functionAcid excretionO-dibutyryl cAMPPrimary hepatocyte culturesExcretionLiverDbcAMPCyclic monophosphateInfusionPericanalicular areaTaurocholate stimulates transcytotic vesicular pathways labeled by horseradish peroxidase in the isolated perfused rat liver
Hayakawa T, Cheng O, Ma A, Boyer J. Taurocholate stimulates transcytotic vesicular pathways labeled by horseradish peroxidase in the isolated perfused rat liver. Gastroenterology 1990, 99: 216-228. PMID: 2344927, DOI: 10.1016/0016-5085(90)91251-z.Peer-Reviewed Original Research
1988
Tubulovesicular Transcytotic Pathway in Isolated Rat Hepatocyte Couplets in Culture Effect of Colchicine and Taurocholate
Sakisaka S, Ng O, Boyer J. Tubulovesicular Transcytotic Pathway in Isolated Rat Hepatocyte Couplets in Culture Effect of Colchicine and Taurocholate. Gastroenterology 1988, 95: 793-804. PMID: 3396824, DOI: 10.1016/s0016-5085(88)80030-1.Peer-Reviewed Original Research
1986
Demonstration of a Transcellular Vesicle Pathway for Biliary Excretion of Inulin in Rat Liver
Lorenzini I, Sakisaka S, Meier P, Boyer J. Demonstration of a Transcellular Vesicle Pathway for Biliary Excretion of Inulin in Rat Liver. Gastroenterology 1986, 91: 1278-1288. PMID: 3758619, DOI: 10.1016/s0016-5085(86)80028-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological TransportHorseradish PeroxidaseInulinLiverMaleRatsRats, Inbred StrainsTaurochenodeoxycholic AcidConceptsTaurochenodeoxycholic acidBiliary excretionTotal bile productionVesicle-mediated transcytosisRenal pedicleBile productionBody wtInulin clearanceIntravenous injectionBasal conditionsLiver homogenatesRatsHepatocellular uptakeExcretionRat liverTranscellular transportTranscellular pathwayBileSubcellular fractionation studiesBloodSimilar effectsVesicle pathwayHorseradish peroxidase