2024
Hepatic GDP-fucose transporter SLC35C1 attenuates cholestatic liver injury and inflammation by inducing CEACAM1 N153 fucosylation.
Zhang L, Xie P, Li M, Zhang X, Fei S, Zhao N, Li L, Xie Q, Xu Z, Tang W, Zhu G, Zhu Z, Xu Z, Li J, Zhang C, Boyer J, Chen W, Cai S, Pan Q, Chai J. Hepatic GDP-fucose transporter SLC35C1 attenuates cholestatic liver injury and inflammation by inducing CEACAM1 N153 fucosylation. Hepatology 2024 PMID: 38985995, DOI: 10.1097/hep.0000000000001003.Peer-Reviewed Original ResearchMouse model of cholestasisModel of cholestasisCholestatic liver injuryLiver injuryMouse modelCXCL2 expressionSolute carrier familyTandem mass spectrometry analysisPrimary mouse hepatocytesLiver-specific ablationMass spectrometry analysisProtein glycosylationSLC35C1Attenuate cholestatic liver injurySTAT3 signalingBile ductular proliferationBile duct ligationCarrier familyLevels of serumCholic acid feedingMolecular mechanismsIncreased liver necrosisMRNA transcriptsFucosylationCXCL2 mRNA expression
2017
Mechanisms of bile acid mediated inflammation in the liver
Li M, Cai SY, Boyer JL. Mechanisms of bile acid mediated inflammation in the liver. Molecular Aspects Of Medicine 2017, 56: 45-53. PMID: 28606651, PMCID: PMC5662014, DOI: 10.1016/j.mam.2017.06.001.Peer-Reviewed Original ResearchConceptsLiver injuryBile acidsCholestatic animal modelsCauses of cholestasisCholestatic liver injuryInnate immune cellsBiliary injuryNeutrophil recruitmentBile flowImmune cellsEffective therapyInflammatory responseAnimal modelsMolecular mediatorsCholestasisInjuryNovel targetLiverElevated levelsPathological processesMolecular mechanismsHepatocytesInflammationPatientsPathogenesis
2008
Arsenic (+3 oxidation state) methyltransferase and the methylation of arsenicals in the invertebrate chordate Ciona intestinalis
Nava G, Lee D, Cai S, Boyer J, Hernández‐Zavala A, Thomas D, Gaskins H. Arsenic (+3 oxidation state) methyltransferase and the methylation of arsenicals in the invertebrate chordate Ciona intestinalis. The FASEB Journal 2008, 22: 796.1-796.1. DOI: 10.1096/fasebj.22.1_supplement.796.1.Peer-Reviewed Original ResearchBranchial sacCiona intestinalisInvertebrate chordate Ciona intestinalisComparative genomics approachChordate Ciona intestinalisArsenic methyltransferaseMethylation of arsenicalsInvertebrate chordatesDimethyl arsenicGenomic approachesRT-PCR analysisBioinformatics analysisMolecular mechanismsConstitutive expressionArsenic biotransformationAS3MT geneCionaMethyltransferaseMethyl arsenicMethylationIntestinalisUseful modelOrthologsChordatesGenome