2019
Underutilization of Androgen Deprivation Therapy with External Beam Radiotherapy in Men with High-grade Prostate Cancer
Wang C, Raldow A, Nickols N, Nguyen P, Spratt D, Dess R, Yu J, King C, Chu F, Chamie K, Litwin M, Saigal C, Reiter R, Liu S, Rettig M, Chang A, Steinberg M, Kupelian P, Kishan A. Underutilization of Androgen Deprivation Therapy with External Beam Radiotherapy in Men with High-grade Prostate Cancer. European Urology Oncology 2019, 4: 327-330. PMID: 31411981, DOI: 10.1016/j.euo.2019.01.006.Peer-Reviewed Original ResearchConceptsConcomitant androgen deprivation therapyAndrogen deprivation therapyExternal beam radiotherapyDefinitive external beam radiotherapyHigh-grade prostate cancerGleason grade groupProstate cancerBeam radiotherapyDeprivation therapyGG 4NHW menDuration of androgen deprivation therapyAA menPopulation-based retrospective studyProstate cancer patientsMultiple randomized trialsNon-HispanicInverse probability treatmentSurvival benefitNon-Hispanic white menRetrospective studyRandomized trialsGrade groupRadiotherapyProbability treatment
2018
Androgen deprivation therapy and risk of rheumatoid arthritis in patients with localized prostate cancer
Yang D, Krasnova A, Nead K, Choueiri T, Hu J, Hoffman K, Yu J, Spratt D, Feng F, Trinh Q, Nguyen P. Androgen deprivation therapy and risk of rheumatoid arthritis in patients with localized prostate cancer. Annals Of Oncology 2018, 29: 386-391. PMID: 29267861, DOI: 10.1093/annonc/mdx744.Peer-Reviewed Original ResearchConceptsAndrogen deprivation therapyDuration of androgen deprivation therapyProstate cancerIncreased riskRheumatoid arthritisDeprivation therapyAutoimmune conditionsAdverse effects of ADTStage I-III prostate cancerEffects of androgen deprivation therapyCompeting risks Cox regressionPharmacological androgen deprivation therapyRA diagnosisLocalized prostate cancerKaplan-Meier ratesRisks Cox regressionInverse probability of treatment weightingProbability of treatment weightingHistory of RACohort of elderly menDiagnosis of RARisk of rheumatoid arthritisUntreated hypogonadismImmunosuppressive propertiesAutoimmune diseases