2011
Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition
Condello C, Schain A, Grutzendler J. Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition. Scientific Reports 2011, 1: 19. PMID: 22355538, PMCID: PMC3216507, DOI: 10.1038/srep00019.Peer-Reviewed Original ResearchConceptsPlaque burdenAmyloid depositionAlzheimer's diseaseAD mouse modelPlaque enlargementClinicopathological studyNeuritic dystrophyPathogenic rolePostmortem studiesAmyloid plaquesNew plaquesConsequent neurotoxicityMouse modelOld plaquesQuantitative confocal imagingCognitive statusPlaquesPlaque expansionOld animalsAmyloid-binding dyesNeurotoxicityDiseasePoor correlationBurdenCritical determinant
2004
Age‐associated synapse elimination in mouse parasympathetic ganglia
Coggan JS, Grutzendler J, Bishop DL, Cook MR, Gan W, Heym J, Lichtman JW. Age‐associated synapse elimination in mouse parasympathetic ganglia. Developmental Neurobiology 2004, 60: 214-226. PMID: 15266652, DOI: 10.1002/neu.20022.Peer-Reviewed Original ResearchConceptsSynapse eliminationExcitatory postsynaptic potential amplitudeSubmandibular ganglion neuronsPostsynaptic potential amplitudeNumber of synapsesMonths of ageMammalian nervous systemAge-related changesMiniature EPSPsSMG neuronsSynapse efficacyParasympathetic gangliaGanglion neuronsEPSP amplitudeSynaptic contactsSynaptic transmissionSynaptic inputsAged animalsPotential amplitudeNervous systemSynaptic boutonsAxonal processesNeuronsOld animalsPostsynaptic membrane