2024
Evaluation of Immunoglobulin A Enzyme Immunoassays to Detect Primary Respiratory Syncytial Virus Infection in Infants and Young Children
Sankaranarayanan R, Ha B, Sun H, Liu K, Jadhao S, Hussaini L, McCracken C, Gibson T, Yildirim I, Yi J, Stephens K, Korski C, Kao C, Rostad C, Anderson E, Anderson L. Evaluation of Immunoglobulin A Enzyme Immunoassays to Detect Primary Respiratory Syncytial Virus Infection in Infants and Young Children. The Journal Of Infectious Diseases 2024, jiae514. PMID: 39575588, DOI: 10.1093/infdis/jiae514.Peer-Reviewed Original ResearchRespiratory syncytial virus infectionRespiratory syncytial virusIgA enzyme immunoassayRespiratory syncytial virus seasonDocumented RSV infectionPlasma specimensEnzyme immunoassayRSV infectionRSV-FRespiratory syncytial virus antibodiesGroup DRespiratory syncytial virus FCord blood specimensGroup C specimensAcute lower respiratory infectionGroup B specimensPresence of maternal antibodiesLower respiratory infectionsImmunoglobulin G antibodiesRSV antibodiesNegative control groupSyncytial virusAntibody enzyme immunoassayRespiratory infectionsGroup BDevelopment and comparison of immunologic assays to detect primary RSV infections in infants
Anderson L, Jadhao S, Hussaini L, Ha B, McCracken C, Gibson T, Yildirim I, Yi J, Stephens K, Korski C, Kao C, Sun H, Lee C, Jaunarajs A, Rostad C, Anderson E. Development and comparison of immunologic assays to detect primary RSV infections in infants. Frontiers In Immunology 2024, 14: 1332772. PMID: 38283339, PMCID: PMC10811012, DOI: 10.3389/fimmu.2023.1332772.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusIgG enzyme immunoassayNeutralizing antibody assaysELISPOT assayAntibody assayRSV antibodiesEnzyme immunoassayRSV infectionSubgroup ARespiratory syncytial virus seasonDocumented RSV infectionPrimary RSV infectionEffective respiratory syncytial virusVaccine clinical trialsEvidence of past infectionEpidemiological studiesRed cell lysisYoung childrenMaternal microchimerismPBMC specimensPregnant womenIFN-gSyncytial virusAntibody enzyme immunoassayELISPOT
2021
Respiratory Syncytial Virus–Associated Mortality Among Young Infants in Karachi, Pakistan: A Prospective Postmortem Surveillance Study
Kazi AM, Aguolu OG, Mughis W, Ahsan N, Jamal S, Khan A, Qureshi HM, Yildirim I, Malik FA, Omer SB. Respiratory Syncytial Virus–Associated Mortality Among Young Infants in Karachi, Pakistan: A Prospective Postmortem Surveillance Study. Clinical Infectious Diseases 2021, 73: s203-s209. PMID: 34472574, PMCID: PMC8411247, DOI: 10.1093/cid/ciab488.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusRespiratory symptomsInfant deathRSV seasonalityRole of RSVYoung infantsPresence of RSVMultivariable logistic regression analysisMaternal immunization strategiesSignificant mortality burdenVaccine-hesitant populationYoung infant deathsMultivariable logistic regressionCold-like symptomsSignificant predictorsLogistic regression analysisPostneonatal ageRSV mortalityRSV seasonMaternal immunizationInfant morbidityNasopharyngeal specimensNasopharyngeal swabsSyncytial virusRespiratory illness
2020
The burden of respiratory syncytial virus infections among children with sickle cell disease
Rostad CA, Maillis AN, Lai K, Bakshi N, Jerris RC, Lane PA, Yee ME, Yildirim I. The burden of respiratory syncytial virus infections among children with sickle cell disease. Pediatric Blood & Cancer 2020, 68: e28759. PMID: 33034160, PMCID: PMC8246443, DOI: 10.1002/pbc.28759.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusSickle cell diseaseRespiratory viral panelRSV-positive casesRSV infectionAnnual incidenceHospitalization ratesCell diseaseBurden of RSVPediatric lower respiratory tract infectionsLaboratory-confirmed RSV infectionRespiratory syncytial virus infectionRSV-related hospitalization rateLower respiratory tract infectionsRSV positive testRSV-negative childrenRSV-negative patientsAcute chest syndromeSyncytial virus infectionRespiratory tract infectionsAverage annual incidenceMultivariate logistic regressionConfidence intervalsCase-control studyOutcome of children
2019
Assessment and Validation of Syndromic Case Definitions for Respiratory Syncytial Virus Infections in Young Infants: A Latent Class Analysis.
Lalani K, Yildirim I, Phadke VK, Bednarczyk RA, Omer SB. Assessment and Validation of Syndromic Case Definitions for Respiratory Syncytial Virus Infections in Young Infants: A Latent Class Analysis. The Pediatric Infectious Disease Journal 2019, 38: 1177-1182. PMID: 31568250, DOI: 10.1097/inf.0000000000002468.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusSyndromic case definitionsCase definitionYoung infantsWorld Health OrganizationRSV infectionLatent class analysisPredictive valueLaboratory-confirmed RSV infectionRespiratory syncytial virus infectionSyncytial virus infectionAcute respiratory infectionsHigh positive predictive valueRoutine clinical careStandardized case definitionsHigh-resource settingsAppropriate case definitionsHigh-income settingsNegative predictive valueMonths of agePositive predictive valueRespiratory infectionsVaccine evaluationClinical featuresPediatric morbidity2314. Burden of Respiratory Syncytial Virus (RSV) Infection Among Hospitalized Older Adults and Those with Underlying Chronic Obstructive Pulmonary Disease (COPD) or Congestive Heart Failure (CHF)
Anderson E, Hussaini L, Bristow L, Tippett A, Gibson T, Hart M, Salazar L, Gaffney M, Benyeogor I, Cheng A, Drobeniuc A, Traenkner J, Fayad D, Washington W, Emerson L, Schwartz N, Greaves K, Todd S, Stanley C, Bechnak A, Chaaya R, Al-Husien Z, Deović R, Winston J, Ahmed D, Li W, Le K, Singh A, Spencer J, Muchinsky A, Zaks K, Nesheim W, Stephens K, Swerdlow D, Hubler R, Agosti Y, Munye M, Jadhao S, Ha B, McCracken C, Kraft C, Rostad C, Kao C, Lopman B, Yildirim I, Anderson L, Rouphael N, Rouphael N. 2314. Burden of Respiratory Syncytial Virus (RSV) Infection Among Hospitalized Older Adults and Those with Underlying Chronic Obstructive Pulmonary Disease (COPD) or Congestive Heart Failure (CHF). Open Forum Infectious Diseases 2019, 6: s793-s794. PMCID: PMC6810302, DOI: 10.1093/ofid/ofz360.1992.Peer-Reviewed Original ResearchChronic obstructive pulmonary diseaseCongestive heart failureAcute respiratory infectionsRespiratory viral panelYears of ageHealthy controlsRespiratory syncytial virus infectionOlder adultsRSV antibody titersSyncytial virus infectionObstructive pulmonary diseaseRespiratory syncytial virusFour-fold riseConvalescent serologyClinical characteristicsHeart failurePulmonary diseaseRespiratory infectionsAsymptomatic adultsEligible adultsProspective surveillanceSyncytial virusViral panelAntibody titersOropharyngeal swabs
2018
2354. Performance of Novel Clinical Case Definitions for Respiratory Syncytial Virus Infections in Young Infants: A Latent Class Analysis
Lalani K, Yildirim I, Phadke V, Bednarczyk R, Omer S. 2354. Performance of Novel Clinical Case Definitions for Respiratory Syncytial Virus Infections in Young Infants: A Latent Class Analysis. Open Forum Infectious Diseases 2018, 5: s700-s701. PMCID: PMC6255342, DOI: 10.1093/ofid/ofy210.2007.Peer-Reviewed Original ResearchRespiratory syncytial virusLaboratory-confirmed RSV infectionAcute respiratory infectionsCase definitionNegative predictive valueWorld Health OrganizationRSV infectionNovel RSV therapeuticsRoutine clinical careLatent class analysisHigh-resource settingsAppropriate case definitionsMonths of ageRSV therapeuticsRespiratory infectionsClinical featuresPediatric morbiditySyncytial virusDisease burdenClinical careChild healthcarePredictive valueYoung infantsMajor causeHealth Organization