2013
Intestine-Specific Mttp Deletion Increases the Severity of Experimental Colitis and Leads to Greater Tumor Burden in a Model of Colitis Associated Cancer
Xie Y, Matsumoto H, Nalbantoglu I, Kerr TA, Luo J, Rubin DC, Kennedy S, Davidson NO. Intestine-Specific Mttp Deletion Increases the Severity of Experimental Colitis and Leads to Greater Tumor Burden in a Model of Colitis Associated Cancer. PLOS ONE 2013, 8: e67819. PMID: 23805328, PMCID: PMC3689718, DOI: 10.1371/journal.pone.0067819.Peer-Reviewed Original ResearchConceptsMttp-IKO miceDextran sodium sulfateDSS treatmentExperimental colitisTumor burdenColitis-Associated CancerDevelopment of colitisIndependent risk factorDietary fat intakeColonic mRNA expressionLevels of TNFαColonic tumor burdenIntestine-specific deletionMicrosomal triglyceride transfer proteinDSS administrationColonic inflammationColonic injuryIL-17AInflammasome expressionSystemic injuryFat intakeFat malabsorptionColorectal cancerCytokine expressionIL-1β
2012
Cytosolic flagellin receptor NLRC4 protects mice against mucosal and systemic challenges
Carvalho F, Nalbantoglu I, Aitken J, Uchiyama R, Su Y, Doho G, Vijay-Kumar M, Gewirtz A. Cytosolic flagellin receptor NLRC4 protects mice against mucosal and systemic challenges. Mucosal Immunology 2012, 5: 288-298. PMID: 22318495, PMCID: PMC3328601, DOI: 10.1038/mi.2012.8.Peer-Reviewed Original ResearchConceptsInflammasome activation resultsDevelopment of colitisDextran sulfate sodiumInnate immune activatorsDetection of flagellinIntestinal gene expressionPredispose miceSulfate sodiumEpithelial injuryIL-18IL-1βImmune activatorsIntestinal homeostasisSevere diseaseFlagellin administrationSalmonella infectionMonoclonal antibodiesSystemic challengesMiceNLRC4Transcription-independent pathwayIntestinal genesAdministrationActivation resultsBacterial flagellin
2011
Interleukin-1β (IL-1β) promotes susceptibility of Toll-like receptor 5 (TLR5) deficient mice to colitis
Carvalho FA, Nalbantoglu I, Ortega-Fernandez S, Aitken JD, Su Y, Koren O, Walters WA, Knight R, Ley RE, Vijay-Kumar M, Gewirtz AT. Interleukin-1β (IL-1β) promotes susceptibility of Toll-like receptor 5 (TLR5) deficient mice to colitis. Gut 2011, 61: 373. PMID: 21646247, DOI: 10.1136/gut.2011.240556.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalCecumColitis, UlcerativeDisease Models, AnimalDisease SusceptibilityGene Expression ProfilingInterleukin-1betaMaleMetagenomeMiceMice, KnockoutMyeloid Differentiation Factor 88Receptors, Interleukin-10Reverse Transcriptase Polymerase Chain ReactionSignal TransductionToll-Like Receptor 5ConceptsToll-like receptor 4T5KO miceGut microbiotaColitis modelIL-1βAbsence of TLR4Toll-like receptor 5 deficient (T5KO) miceAnti-inflammatory cytokine interleukin-10Endogenous anti-inflammatory pathwayToll-like receptor 5Loss of TLR5Anti-inflammatory pathwayIL-10 receptorCytokine interleukin-10Double knockoutIL-10 signalingIL-1 receptorProinflammatory gene expressionWild-type littermatesColitogenic microbiotaSpontaneous colitisUniform colitisSevere colitisImmune dysregulationIntestinal inflammation