2005
Inhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with congenital heart disease
Bizzarro M, Gross I. Inhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with congenital heart disease. Cochrane Database Of Systematic Reviews 2005, cd005055. PMID: 16235391, DOI: 10.1002/14651858.cd005055.pub2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMean pulmonary arterial pressurePulmonary hypertensive crisisCongenital heart diseaseLong-term mortalityHeart diseasePulmonary hypertensionHeart rateHospital stayArterial pressureNitric oxidePostoperative managementMethodologic qualityMethaemoglobin levelsNeurodevelopmental disabilitiesEfficacy of iNOUse of iNOCochrane Central RegisterPulmonary arterial pressureSystemic blood pressureSubgroup of patientsHigh methodologic qualityMajority of outcomesMarkers of toxicityConventional managementHypertensive crisis
1997
Inhaled Nitric Oxide and Persistent Pulmonary Hypertension of the Newborn
Roberts J, Fineman J, Morin F, Shaul P, Rimar S, Schreiber M, Polin R, Zwass M, Zayek M, Gross I, Heymann M, Zapol W, Thusu K, Zellers T, Wylam M, Zaslavsky A. Inhaled Nitric Oxide and Persistent Pulmonary Hypertension of the Newborn. New England Journal Of Medicine 1997, 336: 605-610. PMID: 9032045, DOI: 10.1056/nejm199702273360902.Peer-Reviewed Original ResearchConceptsPersistent pulmonary hypertensionPulmonary vascular resistanceExtracorporeal membrane oxygenationPulmonary hypertensionSystemic oxygenationNitric oxideSevere hypoxemiaVascular resistanceMembrane oxygenationSystemic arterial hypoxemiaSystemic blood pressureLong-term therapyFull-term infantsNumber of deathsSystemic hypotensionArterial hypoxemiaBlood pressureMulticenter studyConventional therapyAlternative therapiesInvasive treatmentNitric oxide groupHypertensionInitial improvementMethemoglobin levels