2019
Effects of Branched-Chain Amino Acid Supplementation on Spontaneous Seizures and Neuronal Viability in a Model of Mesial Temporal Lobe Epilepsy
Gruenbaum SE, Dhaher R, Rapuano A, Zaveri HP, Tang A, de Lanerolle N, Eid T. Effects of Branched-Chain Amino Acid Supplementation on Spontaneous Seizures and Neuronal Viability in a Model of Mesial Temporal Lobe Epilepsy. Journal Of Neurosurgical Anesthesiology 2019, 31: 247-256. PMID: 29620688, PMCID: PMC6170745, DOI: 10.1097/ana.0000000000000499.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyTemporal lobe epilepsyLobe epilepsySpontaneous seizuresNeuron lossSeizure propagationBranched-chain amino acid supplementationChronic oral supplementationSpontaneous recurrent seizuresEffect of BCAAPotential novel treatmentBranched-chain amino acid leucineAmino acid supplementationAcute seizuresBCAA supplementationChronic seizuresConvulsive seizuresOral supplementationRecurrent seizuresRefractory epilepsyDentate hilusNeuronal viabilityAcid supplementationImmunohistochemical analysisNovel treatments
2003
A Retrospective Analysis of Hippocampal Pathology in Human Temporal Lobe Epilepsy: Evidence for Distinctive Patient Subcategories
De Lanerolle NC, Kim JH, Williamson A, Spencer SS, Zaveri HP, Eid T, Spencer DD. A Retrospective Analysis of Hippocampal Pathology in Human Temporal Lobe Epilepsy: Evidence for Distinctive Patient Subcategories. Epilepsia 2003, 44: 677-687. PMID: 12752467, DOI: 10.1046/j.1528-1157.2003.32701.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultApoptosisCell CountCulture TechniquesDentate GyrusDynorphinsElectroencephalographyEpilepsy, Temporal LobeEvoked PotentialsFemaleFollow-Up StudiesHippocampusHumansImmunoenzyme TechniquesInterneuronsMaleNeuronsNeuropeptide YReference ValuesRetrospective StudiesSclerosisSomatostatinSubstance PTreatment OutcomeConceptsIntractable temporal lobe epilepsyTemporal lobe epilepsyDentate granule cellsLobe epilepsySurgical outcomesNeuronal lossNeuronal densityGranule cellsDentate gyrusNonsclerotic hippocampiRetrospective analysisHippocampal subfieldsHuman temporal lobe epilepsyBasis of pathophysiologyEvidence of sclerosisSignificant neuronal lossExtensive neuronal lossSharp electrode recordingsPatient subcategoriesSignificant hyperexcitabilityAutopsy controlsHippocampal pathologyNeuropeptide YImmunohistochemical characteristicsSubstance P