2016
The relationship between seizures, interictal spikes and antiepileptic drugs
Goncharova II, Alkawadri R, Gaspard N, Duckrow RB, Spencer DD, Hirsch LJ, Spencer SS, Zaveri HP. The relationship between seizures, interictal spikes and antiepileptic drugs. Clinical Neurophysiology 2016, 127: 3180-3186. PMID: 27292227, DOI: 10.1016/j.clinph.2016.05.014.Peer-Reviewed Original ResearchConceptsFirst seizureSeizure occurrenceAED taperSpike rateEEG monitoringMarker of inhibitionIntracranial EEG monitoringOccurrence of seizuresScalp EEG monitoringConsecutive patientsAntiepileptic drugsDrug taperHigh spike ratesInterictal spikesSeizuresDay 4Intracranial electrodesPatientsAEDsSignificant relationship
2008
Interictal spikes on intracranial recording: Behavior, physiology, and implications
Spencer SS, Goncharova II, Duckrow RB, Novotny EJ, Zaveri HP. Interictal spikes on intracranial recording: Behavior, physiology, and implications. Epilepsia 2008, 49: 1881-1892. PMID: 18479398, DOI: 10.1111/j.1528-1167.2008.01641.x.Peer-Reviewed Original ResearchConceptsInterictal spikesAED withdrawalSeizure onsetSpike rateMedial temporal lobe seizuresAntiepileptic drug changesRefractory epileptic patientsTemporal lobe seizuresOnset seizuresDrug changesEpileptic patientsNeocortical locationsClinical meaningMedial temporalSeizuresIntracranial electrodesDays of recordingAED mechanismsIntracranial recordingsSignificant increaseAEDsPrevious reportsOnsetSpecific effectsWithdrawal