HELZ2 Is an IFN Effector Mediating Suppression of Dengue Virus
Fusco D, Pratt H, Kandilas S, Cheon S, Lin W, Cronkite D, Basavappa M, Jeffrey K, Anselmo A, Sadreyev R, Yapp C, Shi X, O'Sullivan J, Gerszten R, Tomaru T, Yoshino S, Satoh T, Chung R. HELZ2 Is an IFN Effector Mediating Suppression of Dengue Virus. Frontiers In Microbiology 2017, 8: 240. PMID: 28265266, PMCID: PMC5316548, DOI: 10.3389/fmicb.2017.00240.Peer-Reviewed Original ResearchChromatin immunoprecipitation-sequencingFunctional genomic screensIFN antiviral responseNuclear receptor interaction proteinIFN signal transductionAntiviral effector genesDengue virusReceptor-interacting proteinHost response to viral infectionHost IFN signalingIFN-stimulated genesResponse to viral infectionGenomic screeningEffector genesInteracting proteinsInfectious dengue virusISRE elementKnockdown cellsAnti-dengue activityCo-immunoprecipitationGene productsSignal transductionTranscriptional programsAntiviral effect of IFNAntiviral effectors