2007
Differential regulation of cholera toxin-inhibited Na-H exchange isoforms by butyrate in rat ileum
Subramanya SB, Rajendran VM, Srinivasan P, Kumar N, Ramakrishna BS, Binder HJ. Differential regulation of cholera toxin-inhibited Na-H exchange isoforms by butyrate in rat ileum. AJP Gastrointestinal And Liver Physiology 2007, 293: g857-g863. PMID: 17690171, DOI: 10.1152/ajpgi.00462.2006.Peer-Reviewed Original Research
2004
Three distinct mechanisms of HCO3− secretion in rat distal colon
Vidyasagar S, Rajendran VM, Binder HJ. Three distinct mechanisms of HCO3− secretion in rat distal colon. American Journal Of Physiology - Cell Physiology 2004, 287: c612-c621. PMID: 15308466, DOI: 10.1152/ajpcell.00474.2003.Peer-Reviewed Original ResearchConceptsRat distal colonShort-chain fatty acidsColonic mucosaDistal colonRat distal colonic mucosaDistal colonic mucosaCl- channel blockerSCFA/Channel blockersSerosal layerCrypt cellsCFTR blockerMicroM DIDSApical membrane anion channelApical membraneSecretionDependent secretionColonLumen ClSecretory mechanismMammalian colonBlockersMucosaStat techniqueDIDS
2003
Apical NHE isoforms differentially regulate butyrate-stimulated Na absorption in rat distal colon
Krishnan S, Rajendran VM, Binder HJ. Apical NHE isoforms differentially regulate butyrate-stimulated Na absorption in rat distal colon. American Journal Of Physiology - Cell Physiology 2003, 285: c1246-c1254. PMID: 12878493, DOI: 10.1152/ajpcell.00598.2002.Peer-Reviewed Original Research
1994
Apical membrane Cl-butyrate exchange: Mechanism of short chain fatty acid stimulation of active chloride absorption in rat distal colon
Rajendran V, Binder H. Apical membrane Cl-butyrate exchange: Mechanism of short chain fatty acid stimulation of active chloride absorption in rat distal colon. The Journal Of Membrane Biology 1994, 141: 51-58. PMID: 7966245, DOI: 10.1007/bf00232873.Peer-Reviewed Original ResearchConceptsRat distal colonFatty acid stimulationDistal colonShort-chain fatty acidsNa-H exchangeActive chloride absorptionHalf maximal inhibitory concentrationAcid stimulationApical membrane vesiclesChain fatty acidsChloride absorptionFatty acid exchangeCl- gradientInhibitory concentrationOutward Cl gradientButyrate concentrationExtravesicular ClColonCellular modelMembrane vesiclesFatty acidsStimulationFunctional NaDisulfonic acidCompelling evidence
1993
Bicarbonate-stimulated [14C]butyrate uptake in basolateral membrane vesicles of rat distal colon
Reynolds D, Rajendran V, Binder H. Bicarbonate-stimulated [14C]butyrate uptake in basolateral membrane vesicles of rat distal colon. Gastroenterology 1993, 105: 725-732. PMID: 8359643, DOI: 10.1016/0016-5085(93)90889-k.Peer-Reviewed Original Research
1991
Mechanism of short-chain fatty acid uptake by apical membrane vesicles of rat distal colon
Mascolo N, Rajendran V, Binder H. Mechanism of short-chain fatty acid uptake by apical membrane vesicles of rat distal colon. Gastroenterology 1991, 101: 331-338. PMID: 2065907, DOI: 10.1016/0016-5085(91)90008-9.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic AcidAnimalsAnionsBicarbonatesBiological Transport, ActiveButyratesButyric AcidCell MembraneColonFatty Acids, VolatileHydrogen-Ion ConcentrationIn Vitro TechniquesIntestinal AbsorptionRatsRats, Inbred Strains
1990
Characterization of butyrate-dependent electroneutral Na-Cl absorption in the rat distal colon
Binder H, Mehta P. Characterization of butyrate-dependent electroneutral Na-Cl absorption in the rat distal colon. Pflügers Archiv - European Journal Of Physiology 1990, 417: 365-369. PMID: 2080102, DOI: 10.1007/bf00370654.Peer-Reviewed Original ResearchConceptsCl absorptionDistal colonCyclic adenosine monophosphateMucosal cyclic adenosine monophosphateElectroneutral NaElectroneutral sodium chloride absorptionAdenosine monophosphateRat distal colonSodium chloride absorptionRinger's solutionNa-H exchangeNet Cl- absorptionCyclic AMP inhibitionNet NaColonRatsInhibitionAMP inhibitionRecent studies
1989
Short-chain fatty acids stimulate active sodium and chloride absorption in vitro in the rat distal colon
Binder H, Mehta P. Short-chain fatty acids stimulate active sodium and chloride absorption in vitro in the rat distal colon. Gastroenterology 1989, 96: 989-996. PMID: 2925072, DOI: 10.1016/0016-5085(89)91614-4.Peer-Reviewed Original ResearchConceptsRat distal colonShort-chain fatty acidsCl absorptionDistal colonNa absorptionNet NaFatty acid stimulationNa-H exchangeHCO3- Ringer's solutionStimulation of NaColonic NaNet Cl- absorptionVoltage-clamp conditionsCarbonic anhydrase inhibitorsFatty acidsCoupling of NaMucosal amilorideChloride absorptionUnidirectional 22NaClamp conditionsButyrate stimulationStimulationColonActive sodiumAcid stimulation