2023
Preclinical evaluation of a brain penetrant PARP PET imaging probe in rat glioblastoma and nonhuman primates
Chen B, Ojha D, Toyonaga T, Tong J, Pracitto R, Thomas M, Liu M, Kapinos M, Zhang L, Zheng M, Holden D, Fowles K, Ropchan J, Nabulsi N, De Feyter H, Carson R, Huang Y, Cai Z. Preclinical evaluation of a brain penetrant PARP PET imaging probe in rat glioblastoma and nonhuman primates. European Journal Of Nuclear Medicine And Molecular Imaging 2023, 50: 2081-2099. PMID: 36849748, DOI: 10.1007/s00259-023-06162-y.Peer-Reviewed Original ResearchConceptsPositron emission tomographyHealthy nonhuman primatesVolume of distributionDistribution volume ratioBrain kineticsRat glioblastoma modelPreclinical evaluationBrain regionsGlioblastoma modelPET tracersNonhuman primatesTumor-bearing ratsEx vivo biodistributionPET imaging resultsActive clinical trialsTreatment of glioblastomaHigh specific uptakeDynamic PET scansNoninvasive quantificationBrain positron emission tomographyNondisplaceable volumeBrain penetrationLow nonspecific uptakePrognostic informationClinical trials
2020
Characterization of Kinetic Isotope Effects and Label Loss in Deuterium-Based Isotopic Labeling Studies
de Graaf RA, Thomas MA, Behar KL, De Feyter HM. Characterization of Kinetic Isotope Effects and Label Loss in Deuterium-Based Isotopic Labeling Studies. ACS Chemical Neuroscience 2020, 12: 234-243. PMID: 33319987, PMCID: PMC9890388, DOI: 10.1021/acschemneuro.0c00711.Peer-Reviewed Original Research
2019
On the magnetic field dependence of deuterium metabolic imaging
de Graaf R, Hendriks AD, Klomp DWJ, Kumaragamage C, Welting D, de Castro C, Brown PB, McIntyre S, Nixon TW, Prompers JJ, De Feyter HM. On the magnetic field dependence of deuterium metabolic imaging. NMR In Biomedicine 2019, 33: e4235. PMID: 31879985, PMCID: PMC7141779, DOI: 10.1002/nbm.4235.Peer-Reviewed Original Research
2018
Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo
De Feyter HM, Behar KL, Corbin ZA, Fulbright RK, Brown PB, McIntyre S, Nixon TW, Rothman DL, de Graaf RA. Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo. Science Advances 2018, 4: eaat7314. PMID: 30140744, PMCID: PMC6105304, DOI: 10.1126/sciadv.aat7314.Peer-Reviewed Original ResearchConceptsOral intakeMetabolic imagingGlucose uptakeHigh-grade brain tumorsRat glioma modelPositron emission tomography (PET) detectionSimilar metabolic patternMetabolic imaging techniquesDeuterium metabolic imagingHigher glucose uptakeGlucose analog 2FDG-PETF-fluoroIntravenous infusionBrain tumorsGlioma modelGlucose metabolismNormal brainTomography detectionAnimal modelsMagnetic resonance spectroscopicTumor tissueHuman liverMetabolic patternsNoninvasive approach
2017
In vivo proton observed carbon edited (POCE) 13C magnetic resonance spectroscopy of the rat brain using a volumetric transmitter and receive‐only surface coil on the proton channel
Kumaragamage C, Madularu D, Mathieu AP, De Feyter H, Rajah MN, Near J. In vivo proton observed carbon edited (POCE) 13C magnetic resonance spectroscopy of the rat brain using a volumetric transmitter and receive‐only surface coil on the proton channel. Magnetic Resonance In Medicine 2017, 79: 628-635. PMID: 28497464, DOI: 10.1002/mrm.26751.Peer-Reviewed Original Research
2010
Adaptations in Mitochondrial Function Parallel, but Fail to Rescue, the Transition to Severe Hyperglycemia and Hyperinsulinemia: A Study in Zucker Diabetic Fatty Rats
Lenaers E, De Feyter H, Hoeks J, Schrauwen P, Schaart G, Nabben M, Nicolay K, Prompers J, Hesselink M. Adaptations in Mitochondrial Function Parallel, but Fail to Rescue, the Transition to Severe Hyperglycemia and Hyperinsulinemia: A Study in Zucker Diabetic Fatty Rats. Obesity 2010, 18: 1100-1107. PMID: 19875988, DOI: 10.1038/oby.2009.372.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAdenine Nucleotide Translocator 1AnimalsDiabetes Mellitus, ExperimentalHyperglycemiaHyperinsulinismIon ChannelsMaleMitochondria, MuscleMitochondrial ProteinsMuscle Fibers, SkeletalObesityOxidation-ReductionOxygen ConsumptionProtein CarbonylationRatsRats, ZuckerSeverity of Illness IndexUncoupling Protein 3ConceptsUncoupling protein 3Palmitoyl-CoAMitochondrial functionZucker diabetic fattyFat oxidative capacityReduced fat oxidative capacityProgressive development of insulin resistanceMitochondrial defectsDevelopment of insulin resistanceCarbonyl cyanide p-trifluoromethoxyphenylhydrazoneIntrinsic mitochondrial defectIntrinsic mitochondrial functionInsulin resistanceMitochondrial dysfunctionMuscle mitochondrial functionPyruvate oxidationMitochondrial adaptationsType 2 diabetesState 3Development of type 2 diabetesMitochondrial capacityProtein 3Fa/fa ratsP-trifluoromethoxyphenylhydrazonePyruvate