2024
Development and initial testing of mindful journey: a digital mindfulness-based intervention for promoting recovery from Substance use disorder
Roos C, Kiluk B, Carroll K, Bricker J, Mun C, Sala M, Kirouac M, Stein E, John M, Palmer R, DeBenedictis A, Frisbie J, Haeny A, Barry D, Fucito L, Bowen S, Witkiewitz K, Kober H. Development and initial testing of mindful journey: a digital mindfulness-based intervention for promoting recovery from Substance use disorder. Annals Of Medicine 2024, 56: 2315228. PMID: 38382111, PMCID: PMC10883107, DOI: 10.1080/07853890.2024.2315228.Peer-Reviewed Original ResearchConceptsSubstance use disordersMindfulness-based interventionsPhone coachingQualitative feedbackPromote recoveryEvidence of feasibilityUse disorderPhase 2Promote long-term recoveryApp featuresUnmet needsAdjunctive interventionTen adultsSmartphone appLong-term recoveryInterventionTherapy videosMindfulness practiceParticipantsOutpatient treatmentMind toolPhase 1CoachingAcceptance dimensionQuantitative ratings
2019
Regulation of Craving and Negative Emotion in Alcohol Use Disorder
Suzuki S, Mell MM, O'Malley SS, Krystal JH, Anticevic A, Kober H. Regulation of Craving and Negative Emotion in Alcohol Use Disorder. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2019, 5: 239-250. PMID: 31892465, PMCID: PMC7010564, DOI: 10.1016/j.bpsc.2019.10.005.Peer-Reviewed Original ResearchConceptsAlcohol use disorderNegative emotionsNegative affectPrefrontal cortexIndividual differencesRegulation conditionsCognitive behavioral therapy treatmentEmotion regulation taskFunctional magnetic resonance imagingNegative affect conditionRegulation of cravingNegative alcohol expectanciesNotable individual differencesSelf-reported cravingBehavioral therapy treatmentUse disordersRegulation successCognitive strategiesAffect conditionRegulation strategiesAlcohol expectanciesPFC regionsNeural mechanismsRegulation taskAUD treatmentLet it be: mindful acceptance down-regulates pain and negative emotion
Kober H, Buhle J, Weber J, Ochsner KN, Wager TD. Let it be: mindful acceptance down-regulates pain and negative emotion. Social Cognitive And Affective Neuroscience 2019, 14: 1147-1158. PMID: 31989171, PMCID: PMC7057281, DOI: 10.1093/scan/nsz104.Peer-Reviewed Original ResearchConceptsMindful acceptanceEmotion regulation strategiesCognitive control systemPrefrontal control systemsMeditation-naïve participantsSelf-report measuresKinds of stimuliEmotion regulationNeutral imagesNegative emotionsAmygdala responseMindfulness trainingNegative affectAffective significanceEmotional intensityRegulation strategiesBrain processesNegative imageInitial appraisalEmotionsLateral pain systemPain systemStimuliParticipantsChronic pain
2018
Training in cognitive strategies reduces eating and improves food choice
Boswell RG, Sun W, Suzuki S, Kober H. Training in cognitive strategies reduces eating and improves food choice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: e11238-e11247. PMID: 30420496, PMCID: PMC6275472, DOI: 10.1073/pnas.1717092115.Peer-Reviewed Original ResearchConceptsCognitive strategiesFood valuationBrief trainingUnhealthy foodsCognitive regulation strategiesFood choicesEffects of framingRegulation strategiesStudy 5Study 1Study 3Unhealthy eatingStudy 6Training componentHealthy food choicesNegative consequencesPositive benefitsCravingHealthy foodsTrainingClinical implicationsPrior workIndividualsImplicationsEating
2015
Boundary Conditions of Methamphetamine Craving
Lopez RB, Onyemekwu C, Hart CL, Ochsner KN, Kober H. Boundary Conditions of Methamphetamine Craving. Experimental And Clinical Psychopharmacology 2015, 23: 436-444. PMID: 26302338, PMCID: PMC4658228, DOI: 10.1037/pha0000049.Peer-Reviewed Original ResearchConceptsCognitive strategiesStudy 1Study 2Cognitive regulation strategiesMethamphetamine useNegative consequencesSmoking stimuliRegulation strategiesStrong cravingsMethamphetamine cravingCravingIntranasal stimuliMethamphetamine smokingPositive aspectsMethamphetamine usersMethamphetamine smokersParticipantsSignificant interactionStimuliClinical implicationsExploratory studyRoute of administrationMethamphetamineSmoking methamphetamineAbstinence
2011
Mindful attention reduces neural and self-reported cue-induced craving in smokers
Westbrook C, Creswell JD, Tabibnia G, Julson E, Kober H, Tindle HA. Mindful attention reduces neural and self-reported cue-induced craving in smokers. Social Cognitive And Affective Neuroscience 2011, 8: 73-84. PMID: 22114078, PMCID: PMC3541484, DOI: 10.1093/scan/nsr076.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingMindful attentionCue-induced cravingSmoking cuesSmoking imagesPresent-moment experienceTreatment-seeking smokersPsychophysiological interaction analysisMindfulness-based interventionsSubgenual anterior cingulate cortexAnterior cingulate cortexNeural reactivityNeutral imagesBody of researchMoment experienceNeural markersAddictive disordersCingulate cortexFunctional connectivityNeural activityCuesMindfulnessCravingSmoking cessationAttention
2010
Prefrontal–striatal pathway underlies cognitive regulation of craving
Kober H, Mende-Siedlecki P, Kross EF, Weber J, Mischel W, Hart CL, Ochsner KN. Prefrontal–striatal pathway underlies cognitive regulation of craving. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 14811-14816. PMID: 20679212, PMCID: PMC2930456, DOI: 10.1073/pnas.1007779107.Peer-Reviewed Original ResearchConceptsSubstance use disordersUse disordersPrefrontal cortexVentral tegmental areaSubstance-dependent populationsMore effective treatmentsLong-term consumptionDorsolateral prefrontal cortex activityPrefrontal cortex activityCigarette smokersTegmental areaVentrolateral prefrontal cortexVentral striatum activityVentral striatal activitySubgenual cingulateEffective treatmentLateral prefrontal cortexStriatal activityVentral striatumCortex activityFunctional imagingPhysical healthStriatum activityNeural activityCortex