2016
Genomic characterization of sarcomatoid transformation in clear cell renal cell carcinoma
Bi M, Zhao S, Said JW, Merino MJ, Adeniran AJ, Xie Z, Nawaf CB, Choi J, Belldegrun AS, Pantuck AJ, Kluger HM, Bilgüvar K, Lifton RP, Shuch B. Genomic characterization of sarcomatoid transformation in clear cell renal cell carcinoma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 2170-2175. PMID: 26864202, PMCID: PMC4776463, DOI: 10.1073/pnas.1525735113.Peer-Reviewed Original ResearchMeSH KeywordsAgedCarcinoma, Renal CellCell DedifferentiationDNA Mismatch RepairDNA-Binding ProteinsExomeFemaleGenes, p53HumansKidney NeoplasmsLoss of HeterozygosityMaleMiddle AgedMutationNuclear ProteinsOncogenesPolymorphism, Single NucleotidePrognosisTranscription FactorsTumor Suppressor ProteinsUbiquitin ThiolesteraseConceptsClear cell renal cell carcinomaCell renal cell carcinomaRenal cell carcinomaSarcomatoid elementsCarcinomatous elementsCell carcinomaSomatic single nucleotide variantsVon Hippel-Lindau tumor suppressorPoor-prognosis cancerTreatment of patientsTumor protein p53 (TP53) mutationsMismatch repair deficiencyRich interaction domain 1ASarcomatoid featuresPoor prognosisUnknown pathogenesisPolybromo-1TP53 mutationsP53 mutationsSarcomatoid transformationPan-cancer genesExome sequencingTumorsRepair deficiencyProtein 1
2011
Molecular Alternations in Uveal Melanoma
Materin MA, Faries M, Kluger HM. Molecular Alternations in Uveal Melanoma. Current Problems In Cancer 2011, 35: 211-224. PMID: 21911184, DOI: 10.1016/j.currproblcancer.2011.07.004.Peer-Reviewed Original Research
2008
Suppressor role of activating transcription factor 2 (ATF2) in skin cancer
Bhoumik A, Fichtman B, DeRossi C, Breitwieser W, Kluger HM, Davis S, Subtil A, Meltzer P, Krajewski S, Jones N, Ronai Z. Suppressor role of activating transcription factor 2 (ATF2) in skin cancer. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 1674-1679. PMID: 18227516, PMCID: PMC2234203, DOI: 10.1073/pnas.0706057105.Peer-Reviewed Original ResearchMeSH Keywords9,10-Dimethyl-1,2-benzanthraceneActivating Transcription Factor 2AnimalsApoptosisBeta CateninCarcinogensCell ProliferationCyclin D1DNAEpidermisKeratinocytesMiceMice, KnockoutPapillomaPresenilin-1Proto-Oncogene Proteins c-mybReceptor, Notch1Skin NeoplasmsTetradecanoylphorbol AcetateTissue Array AnalysisTumor Suppressor ProteinsConceptsSkin tumor formationTranscription factor 2Two-stage skin carcinogenesis protocolTumor formationBasal cell carcinomaSkin carcinogenesis protocolFactor 2K14-Cre miceCell carcinomaCarcinogenesis protocolMouse modelBeta-catenin expressionPapilloma developmentSkin cancerExhibit reduced expressionAnchorage-independent growthNormal skinNotch1 expressionCyclin D1MiceReduced expressionSuppressor roleSuppressor activitySelective expressionBasal layer