2022
Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice
Bhat N, Narayanan A, Fathzadeh M, Kahn M, Zhang D, Goedeke L, Neogi A, Cardone RL, Kibbey RG, Fernandez-Hernando C, Ginsberg HN, Jain D, Shulman G, Mani A. Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice. Journal Of Clinical Investigation 2022, 132: e153724. PMID: 34855620, PMCID: PMC8803348, DOI: 10.1172/jci153724.Peer-Reviewed Original ResearchConceptsDe novo lipogenesisNonalcoholic steatohepatitisInsulin resistanceHepatic lipogenesisElevated de novo lipogenesisNonalcoholic fatty liver diseaseFatty liver diseaseLiver of patientsHepatic glycogen storageHigh-sucrose dietHepatic insulin resistanceFatty acid uptakeMetabolic syndromeLiver diseaseHepatic steatosisTriacylglycerol secretionNovo lipogenesisHepatic insulinTherapeutic targetImpaired activationAcid uptakeGlycogen storageMouse liverLiverLipogenesis
2001
Regulation of Hepatic Glucose Uptake
Taylor R, Shulman G. Regulation of Hepatic Glucose Uptake. 2001, 787-802. DOI: 10.1002/cphy.cp070226.Peer-Reviewed Original ResearchHepatic glucose productionHepatic glucose uptakeGlucose productionGlucose uptakeHepatic glycogen storageLiver glycogen storesHepatic glycogen contentGlycogen storage diseaseNormal diurnal fluctuationsPortal signalPostprandial statePostabsorptive stateGlycogen storesGlycogen contentGlucagon regulationGlycogen storageHomeostatic mechanismsStorage diseaseGlycogen synthesisEarly adaptationMetabolismGlucose carbonCirrhosis