1995
Transmissible Retrovirus in Epstein-Burr Virus-Producer B95-8 Cells
Sun R, Grogan E, Shedd D, Bykovsky A, Kushnaryov V, Grossberg S, Miller G. Transmissible Retrovirus in Epstein-Burr Virus-Producer B95-8 Cells. Virology 1995, 209: 374-383. PMID: 7778272, DOI: 10.1006/viro.1995.1269.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBetaretrovirusB-LymphocytesCallithrixCell LineCloning, MolecularDNA PrimersDNA, ComplementaryGene LibraryGene Products, gagGenes, gagHerpesvirus 4, HumanHumansMicroscopy, ElectronMolecular Sequence DataPolymerase Chain ReactionRepetitive Sequences, Nucleic AcidSaimiriT-LymphocytesVirus ReplicationConceptsEpstein-Barr virusB95-8 cellsAbsence of EBVCell linesB95-8 isolateB95-8 strainMarmoset cell linesHuman lymphoid cell linesT cell linesLymphoid cell linesType D retrovirusHuman BLymphocyte immortalizationInfectious virusViral replicationHuman isolatesGag regionBiologic propertiesTransmissible retrovirusUltrastructural appearanceD retrovirusesAmino acid changesVirusSMRVGag sequences
1990
Inhibition of specific binding of EBNA 1 to DNA by Murine Monoclonal and certain human polyclonal antibodies
Orlowski R, Polvino-Bodnar M, Hearing J, Miller G. Inhibition of specific binding of EBNA 1 to DNA by Murine Monoclonal and certain human polyclonal antibodies. Virology 1990, 176: 638-642. PMID: 2161154, DOI: 10.1016/0042-6822(90)90036-q.Peer-Reviewed Original ResearchConceptsEBNA-1 proteinGel mobility shift experimentsMobility shift experimentsSequence-specific DNARecognition of DNAEBNA-1Binding of DNASpecific bindingLac promoterDNA bindingMonoclonal antibodiesDimerization siteSpecific DNANonfusion proteinBurkitt's lymphoma cellsShift experimentsMolecular massEscherichia coliProteinDNASame monoclonal antibodyBindingPolyclonal antibodiesEB virusLymphoma cells
1986
Animal model for Epstein-Barr lymphoma
MILLER G. Animal model for Epstein-Barr lymphoma. Nature 1986, 319: 626-626. PMID: 3005864, DOI: 10.1038/319626c0.Peer-Reviewed Original Research
1985
Identification and expression of a nuclear antigen from the genomic region of the Jijoye strain of Epstein-Barr virus that is missing in its nonimmortalizing deletion mutant, P3HR-1.
Rowe D, Heston L, Metlay J, Miller G. Identification and expression of a nuclear antigen from the genomic region of the Jijoye strain of Epstein-Barr virus that is missing in its nonimmortalizing deletion mutant, P3HR-1. Proceedings Of The National Academy Of Sciences Of The United States Of America 1985, 82: 7429-7433. PMID: 2997790, PMCID: PMC391358, DOI: 10.1073/pnas.82.21.7429.Peer-Reviewed Original ResearchConceptsChronic active EBV infectionActive EBV infectionEpstein-Barr virusJijoye strainEBV infectionEBV DNACertain patientsP3HR-1Human antiseraVirus strainsNuclear antigenHr-1JijoyeVirus deletion mutantsLtk- cellsMouse Ltk- cellsImmortalization processPatientsGene transferNeoantigensLymphocytesInfectionAntigen
1984
Regions of the EBV genome involved in latency and lymphocyte immortalization.
Miller G. Regions of the EBV genome involved in latency and lymphocyte immortalization. Medical Virology 1984, 30: 107-28. PMID: 6087408.Peer-Reviewed Original ResearchAnimalsAntigens, ViralB-LymphocytesCell NucleusCell Transformation, ViralChildChild, PreschoolChromosome DeletionDNA, ViralEpstein-Barr Virus Nuclear AntigensFemaleGenes, ViralHerpesvirus 4, HumanHumansLymphomaMaleRepetitive Sequences, Nucleic AcidRNA, ViralTranscription, GeneticTumor Virus InfectionsVirionVirus Replication
1982
Neutralization of lymphocyte immortalization by different strains of Epstein-Barr virus with a murine monoclonal antibody
Miller G, Heston L, Hoffman G. Neutralization of lymphocyte immortalization by different strains of Epstein-Barr virus with a murine monoclonal antibody. Infection And Immunity 1982, 37: 1028-1031. PMID: 6182100, PMCID: PMC347642, DOI: 10.1128/iai.37.3.1028-1031.1982.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusMurine monoclonal antibodiesMonoclonal antibodiesCases of mononucleosisB95-8 strainBurkitt's lymphoma cell linesPolyclonal lymphomaBlood transfusionEBV strainsAmerican patientsChallenge virusLymphoma cell linesBurkitt's lymphomaLymphocyte immortalizationAfrican childrenHybridoma antibodiesAntigenic differencesAntibodiesMarmoset cellsMononucleosisVirusAntigenic sitesCell linesLymphomaAntigen
1979
Cross-neutralization of infectious mononucleosis and Burkitt lymphoma strains of Epstein-Barr virus with hyperimmune rabbit antisera.
Coope D, Heston L, Brandsma J, Miller G. Cross-neutralization of infectious mononucleosis and Burkitt lymphoma strains of Epstein-Barr virus with hyperimmune rabbit antisera. The Journal Of Immunology 1979, 123: 232-8. PMID: 221591, DOI: 10.4049/jimmunol.123.1.232.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusCell linesMarmoset lymphoblastoid cell lineHuman B lymphoid cellsHR-1 strainDiverse biologic propertiesSource of antigenLymphoblastoid T-cell lineCross-absorption testsT cell linesSera of rabbitsB-lymphoid cellsInhibition of inductionVirus producer cellsImmunization of rabbitsInfectious mononucleosisSupernatant culture fluidsEB virusEarly antigenHyperimmune rabbit antiserumAntibody titersInhibition of transformationLymphoblastoid cell linesLymphoid cellsNormal lymphocytes
1978
Radiobiological Inactivation of Epstein-Barr Virus
Henderson E, Heston L, Grogan E, Miller G. Radiobiological Inactivation of Epstein-Barr Virus. Journal Of Virology 1978, 25: 51-59. PMID: 202757, PMCID: PMC353900, DOI: 10.1128/jvi.25.1.51-59.1978.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusEarly antigen inductionAntigen inductionStrain of EBVAbility of EBVHerpes simplex virus type 1B95-8 virusSimplex virus type 1Herpes simplex virusVirus type 1X-irradiationCell DNA synthesisHost cell DNA synthesisLymphoid cell linesEBV genomeB95-8EBV transformationSimplex virusPlaque formationType 1Nuclear antigenMechanisms of repairPrimary lymphocytesCell clonesDose of irradiation
1977
Efficiency of transformation of lymphocytes by Epstein-Barr virus
Henderson E, Miller G, Robinson J, Heston L. Efficiency of transformation of lymphocytes by Epstein-Barr virus. Virology 1977, 76: 152-163. PMID: 189490, DOI: 10.1016/0042-6822(77)90292-6.Peer-Reviewed Original ResearchConceptsHuman umbilical cord leukocytesEpstein-Barr virusCord blood leukocytesBlood leukocytesMixed mononuclear cellsSusceptible cellsB95-8 strainUmbilical cord leukocytesSusceptibility of lymphocytesHuman placental cellsUmbilical cord cellsVirus-exposed cellsMultiplicity of infectionMononuclear cellsT lymphocytesMononuclear leukocytesCord cellsPlacental cellsAutochthonous lymphocytesViral factorsLymphocytesMarmoset bloodCellular DNA synthesisLeukocytesAdult humans
1975
Differences between laboratory strains of Epstein-Barr virus based on immortalization, abortive infection and interference.
Miller G, Robinson J, Heston L, Lipman M. Differences between laboratory strains of Epstein-Barr virus based on immortalization, abortive infection and interference. IARC Scientific Publications 1975, 395-408. PMID: 190145.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusEarly antigenH virusInitiation of immortalizationAntibody-negative human serumPretreatment of lymphocytesNon-producer cell linesCell linesHuman umbilical cordHuman serumInfectious mononucleosisCarrier cell linesB95-8Umbilical cordBurkitt's lymphomaLymphocyte immortalizationDNA synthesisLaboratory strainsStimulation of DNAHuman lymphocytesLymphocytesBiological behaviorPrimary culturesAbortive infectionAntigen
1974
Expression of Epstein-Barr viral capsid, complement fixing, and nuclear antigens in stationary and exponential phase cultures.
Miller G, Heston L. Expression of Epstein-Barr viral capsid, complement fixing, and nuclear antigens in stationary and exponential phase cultures. The Yale Journal Of Biology And Medicine 1974, 47: 123-35. PMID: 4372815, PMCID: PMC2596417.Peer-Reviewed Original ResearchConceptsViral capsid antigenEpstein-Barr viralCapsid antigenNuclear antigenComplement fixingContinuous lymphoblastoid cell linesEpstein-Barr viral capsidViable cellsContent of antigensProportion of cellsLymphocyte transformationAnticomplement immunofluorescenceLymphoblastoid cell linesComplement-fixing (CF) antigenCell subpopulationsComplement fixationAntigenAntigen complexIntranuclear antigensProducer linesCell linesCells
1973
Malignant Lymphoma in Cottontop Marmosets after Inoculation with Epstein-Barr Virus
Shope T, Dechairo D, Miller G. Malignant Lymphoma in Cottontop Marmosets after Inoculation with Epstein-Barr Virus. Proceedings Of The National Academy Of Sciences Of The United States Of America 1973, 70: 2487-2491. PMID: 4354852, PMCID: PMC427039, DOI: 10.1073/pnas.70.9.2487.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusMalignant lymphomaImmunosuppressive drugsCottontop marmosetsCell-free Epstein-Barr virusCourse of diseaseCell-free virusHuman malignant lymphomasSarcoma typesVirus antigenAddition of virusLymphomaAutologous cellsTumor formationLatent periodOncogenic capacityOrgan cultureMarmosetsVirusTumorsAntibodiesDrugsAdditional evidenceCellsNeoplasiaProlonged Oropharyngeal Excretion of Epstein–Barr Virus after Infectious Mononucleosis
Miller G, Niederman J, Andrews L. Prolonged Oropharyngeal Excretion of Epstein–Barr Virus after Infectious Mononucleosis. New England Journal Of Medicine 1973, 288: 229-232. PMID: 4345064, DOI: 10.1056/nejm197302012880503.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusThroat washesInfectious mononucleosisEpstein-Barr viral antigensEpstein-Barr virus antibodiesInfectious mononucleosis syndromeUmbilical cord leukocytesOropharyngeal excretionClinical symptomsControl subjectsSerum antibodiesVirus antibodiesViral antigensBlood leukocytesSuch antigensComplement fixationContinuous cell linesFactor presentMononucleosisAntibodiesReference seraPatientsCell linesSyndromeLeukocytesRelease of Infectious Epstein-Barr Virus by Transformed Marmoset Leukocytes
Miller G, Lipman M. Release of Infectious Epstein-Barr Virus by Transformed Marmoset Leukocytes. Proceedings Of The National Academy Of Sciences Of The United States Of America 1973, 70: 190-194. PMID: 4346033, PMCID: PMC433213, DOI: 10.1073/pnas.70.1.190.Peer-Reviewed Original Research
1972
Epstein-Barr Virus: Transformation, Cytopathic Changes, and Viral Antigens in Squirrel Monkey and Marmoset Leukocytes
Miller G, Shope T, Lisco H, Stitt D, Lipman M. Epstein-Barr Virus: Transformation, Cytopathic Changes, and Viral Antigens in Squirrel Monkey and Marmoset Leukocytes. Proceedings Of The National Academy Of Sciences Of The United States Of America 1972, 69: 383-387. PMID: 4333982, PMCID: PMC426463, DOI: 10.1073/pnas.69.2.383.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen-Antibody ReactionsAntigens, ViralCattleCell LineCell Transformation, NeoplasticCells, CulturedChromosomesComplement Fixation TestsCytopathogenic Effect, ViralFetusFibroblastsFluorescent Antibody TechniqueHaplorhiniHerpesviridaeHerpesvirus 4, HumanHumansImmune SeraKidneyLeukocytesPathologyPlacentaConceptsEpstein-Barr virus antigensEpstein-Barr virusVirus antigenGiant cellsMultinucleate giant cellsViral antigensBlood leukocytesCytopathic changesNew World primatesInfectious virusIntranuclear inclusionsSquirrel monkeysAntigenLymphoblastoid cellsVirusLeukocytesWorld primatesSimian cellsCellsLarge proportionMultinucleate cells