2022
Association of propofol induction dose and severe pre-incision hypotension among surgical patients over age 65
Schonberger RB, Dai F, Michel G, Vaughn MT, Burg MM, Mathis M, Kheterpal S, Akhtar S, Shah N, Bardia A. Association of propofol induction dose and severe pre-incision hypotension among surgical patients over age 65. Journal Of Clinical Anesthesia 2022, 80: 110846. PMID: 35489305, PMCID: PMC11150018, DOI: 10.1016/j.jclinane.2022.110846.Peer-Reviewed Original ResearchConceptsPropofol induction doseGeneral anesthetic inductionSevere hypotensionInduction doseBlood pressure measurementsYears of ageSurgical patientsEndotracheal intubationAnesthetic inductionInvasive blood pressure measurementsGeriatric surgical patientsNon-vascular surgeryDose of propofolNon-invasive blood pressure measurementBlood pressure dropSignificant independent associationPostoperative morbidityRetrospective observationalTotal patientsMulticenter cohortPrimary outcomeAnesthesia inductionPrimary exposureIndependent associationSurgical incision
2021
Variation in propofol induction doses administered to surgical patients over age 65
Schonberger RB, Bardia A, Dai F, Michel G, Yanez D, Curtis JP, Vaughn MT, Burg MM, Mathis M, Kheterpal S, Akhtar S, Shah N. Variation in propofol induction doses administered to surgical patients over age 65. Journal Of The American Geriatrics Society 2021, 69: 2195-2209. PMID: 33788251, PMCID: PMC8373684, DOI: 10.1111/jgs.17139.Peer-Reviewed Original ResearchConceptsPropofol induction dosesInduction dosesEndotracheal intubationGeneral anesthetic inductionPropofol induction dosePercent of patientsRetrospective observational studyLarge multicenter cohortSurgical patientsMulticenter cohortPropofol doseBolus doseGeneral anesthesiaInduction dosePropofol inductionPresent studyAnesthetic inductionDose administrationAdvanced agePatient variablesObservational studyProvider practicesAnaesthetic practiceClinical consequencesDosing decisions
2020
An Analysis of Anesthesia Induction Dosing in Female Older Adults
Chen EY, Michel G, Zhou B, Dai F, Akhtar S, Schonberger RB. An Analysis of Anesthesia Induction Dosing in Female Older Adults. Drugs & Aging 2020, 37: 435-446. PMID: 32300966, PMCID: PMC7359723, DOI: 10.1007/s40266-020-00760-3.Peer-Reviewed Original ResearchConceptsAcute kidney injuryPostinduction hypotensionGeneral anesthesiaPresent cohortPostoperative acute kidney injuryLarge tertiary teaching hospitalOlder adultsFrailty of patientsGynecologic oncology surgeryImmediate hemodynamic effectsPropofol induction dosesPercentage of patientsRetrospective observational studyTertiary teaching hospitalPerioperative vital signsHigher propofol dosesFemale older adultsAKI associationInotrope administrationKidney injurySurgical populationHemodynamic effectsDose adjustmentPrimary outcomeFemale patients
2019
Preference Phenotypes in Support of Shared Decision–Making at Point‐of‐Care for Patients With Rheumatoid Arthritis: A Proof‐of‐Concept Study
Hsiao B, Binder‐Finnema P, Nowell W, Michel G, Wiedmeyer C, Fraenkel L. Preference Phenotypes in Support of Shared Decision–Making at Point‐of‐Care for Patients With Rheumatoid Arthritis: A Proof‐of‐Concept Study. Arthritis Care & Research 2019, 71: 629-637. PMID: 29953733, PMCID: PMC6310675, DOI: 10.1002/acr.23684.Peer-Reviewed Original ResearchConceptsDisease-modifying antirheumatic drugsNew disease-modifying antirheumatic drugsValues clarification toolPost-test visitsMore disease-modifying antirheumatic drugsTest visitsPretest/post-test studyAntirheumatic drugsMore patientsOutpatient visitsRheumatoid arthritisConcept studyPost-test studyPatientsPatient valuesSD lengthPost-test phaseVisitsActive RAVisit timeCarePretest phaseEscalation decisionsPreference phenotypesPhenotypeImpact of Information Presentation Format on Preference for Total Knee Replacement Surgery
Fraenkel L, Nowell WB, Stake CE, Venkatachalam S, Eyler R, Michel G, Peters E. Impact of Information Presentation Format on Preference for Total Knee Replacement Surgery. Arthritis Care & Research 2019, 71: 379-384. PMID: 29799668, PMCID: PMC6252282, DOI: 10.1002/acr.23605.Peer-Reviewed Original Research
2017
Preference phenotypes to facilitate shared decision-making in rheumatoid arthritis
Fraenkel L, Nowell WB, Michel G, Wiedmeyer C. Preference phenotypes to facilitate shared decision-making in rheumatoid arthritis. Annals Of The Rheumatic Diseases 2017, 77: 678. PMID: 29247126, PMCID: PMC5898982, DOI: 10.1136/annrheumdis-2017-212407.Peer-Reviewed Original ResearchConceptsBothersome side effectsRare side effectRheumatoid arthritisSide effectsSerious infectionsOnset of actionJanus kinase inhibitorPreferences of patientsMethotrexate monotherapyTriple therapyParenteral medicationsPoint of careTreatment preferencesGroup 2Patient valuesPatientsGroup 4Target strategyGroup 5Kinase inhibitorsConjoint analysis surveyLatent class analysisLarge groupArthritisMedications