2012
Altered Response to Neuroendocrine Challenge Linked to Indices of the Metabolic Syndrome in Healthy Adults
Tyrka A, Walters O, Price L, Anderson G, Carpenter L. Altered Response to Neuroendocrine Challenge Linked to Indices of the Metabolic Syndrome in Healthy Adults. Hormone And Metabolic Research 2012, 44: 543-549. PMID: 22549400, PMCID: PMC3580172, DOI: 10.1055/s-0032-1306342.Peer-Reviewed Original ResearchConceptsDEX/CRH testBody mass indexHealthy adultsCRH testBlood pressureACTH responseMetabolic syndromeAdrenocorticotropic hormoneDexamethasone/corticotropin-releasing hormone testCorticotropin-releasing hormone testIndices of MetSHPA axis functionNeuroendocrine challenge testsAdrenal axis activityPathogenesis of MetS.Significant medical problemEarly life stressHealthy community sampleCommunity sampleCentral obesityChronic medicationsMetS componentsHDL cholesterolCentral adiposityDevelopment of disease
2004
Effects of glucocorticoids on declarative memory function in major depression
Bremner J, Vythilingam M, Vermetten E, Anderson G, Newcomer J, Charney D. Effects of glucocorticoids on declarative memory function in major depression. Biological Psychiatry 2004, 55: 811-815. PMID: 15050862, DOI: 10.1016/j.biopsych.2003.10.020.Peer-Reviewed Original ResearchConceptsMajor depressive disorderDeclarative memory functionVerbal declarative memory functionDay 3Major depressionMemory functionParagraph recallUnipolar major depressive disorderSubset of patientsEffects of glucocorticoidsHealthy human subjectsDepressive disorderTransient impairmentHealthy subjectsRandomized fashionDeclarative memoryGlucocorticoid receptorBrain regionsExogenous cortisolGlucocorticoidsPlaceboDexamethasonePatientsBaselineDepression
2001
Relationship Among Plasma Cortisol, Catecholamines, Neuropeptide Y, and Human Performance During Exposure to Uncontrollable Stress
Morgan C, Wang S, Rasmusson A, Hazlett G, Anderson G, Charney D. Relationship Among Plasma Cortisol, Catecholamines, Neuropeptide Y, and Human Performance During Exposure to Uncontrollable Stress. Psychosomatic Medicine 2001, 63: 412-422. PMID: 11382268, DOI: 10.1097/00006842-200105000-00010.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderStress disorderPsychobiological responsesUncontrollable stressThreat response systemStress-related illnessesIndividual differencesTrauma exposurePsychological dissociationAversive experiencesNeurobiological factorsHuman performanceBehavioral indicesSurvival SchoolNeurobiological perturbationsNeurobiological responsesPsychological symptomsCatecholamine functioningMilitary performanceDisordersNeuropeptide YCortisol releaseIndividualsAdrenocortical axisNeuropeptide Y release
2000
Cerebrospinal Fluid Corticotropin-Releasing Hormone in Healthy Humans: Effects of Yohimbine and Naloxone1
Vythilingam M, Anderson G, Owens M, Halaszynski T, Bremner J, Carpenter L, Heninger G, Nemeroff C, Charney D. Cerebrospinal Fluid Corticotropin-Releasing Hormone in Healthy Humans: Effects of Yohimbine and Naloxone1. The Journal Of Clinical Endocrinology & Metabolism 2000, 85: 4138-4145. PMID: 11095445, DOI: 10.1210/jcem.85.11.6968.Peer-Reviewed Original ResearchConceptsCRH neuronsParaventricular nucleusCSF CRHCerebrospinal fluidPlasma cortisolHypothalamic pituitary adrenal axis activityCSF CRH concentrationsCSF CRH levelsCorticotropin-Releasing HormoneCSF NE levelsEffects of yohimbineAdult normal volunteersPlasma cortisol concentrationsCRH concentrationsCentral norepinephrineOpioid regulationPlacebo administrationPVN neuronsCRH levelsNE levelsCSF norepinephrineHPA axisAxis activityHealthy humansMedian eminence
1997
Plasma β‐Endorphin, Adrenocorticotropin Hormone, and Cortisol in Autism
Tordjman S, McBride P, Hertzig M, Snow M, Anderson G, Hall L, Thompson S, Ferrari P, Cohen D. Plasma β‐Endorphin, Adrenocorticotropin Hormone, and Cortisol in Autism. Journal Of Child Psychology And Psychiatry 1997, 38: 705-715. PMID: 9315980, DOI: 10.1111/j.1469-7610.1997.tb01697.x.Peer-Reviewed Original ResearchConceptsAdrenocorticotropin hormoneBeta-endorphinPlasma levelsHigher plasma levelsPlasma β-endorphinNormal control individualsAcute stress responseΒ-endorphinNormal controlsControl individualsAcute stressorChronic hyperarousalStress response systemSevere autismCortisolAutistic groupHormoneIndividualsGroupHighest meanAutistic individualsLevelsStress response
1994
Enhanced stress responsivity of tourette syndrome patients undergoing lumbar puncture
Chappell P, Riddle M, Anderson G, Scahill L, Hardin M, Walker D, Cohen D, Leckman J. Enhanced stress responsivity of tourette syndrome patients undergoing lumbar puncture. Biological Psychiatry 1994, 36: 35-43. PMID: 8080901, DOI: 10.1016/0006-3223(94)90060-4.Peer-Reviewed Original ResearchConceptsTS patientsLumbar punctureNormal controlsTourette syndromeClinician ratingsEnhanced stress responsivityLumbar puncture stressUrinary norepinephrine excretionTourette syndrome patientsPeak ACTH levelsNorepinephrine excretionACTH levelsSympathetic systemAdrenal axisMedication responsivenessMore norepinephrinePhonic ticsSyndrome patientsUrinary catecholaminesMore ACTHPatientsTic severityNeuropsychiatric disordersSymptom severityStress responsivity
1981
Plasma free MHPG and neuroendocrine responses to challenge doses of clonidine in Tourette's Syndrome: Preliminary report
Young J, Cohen D, Hattox S, Kavanagh M, Anderson G, Shaywitz B, Maas J. Plasma free MHPG and neuroendocrine responses to challenge doses of clonidine in Tourette's Syndrome: Preliminary report. Life Sciences 1981, 29: 1467-1475. PMID: 6946271, DOI: 10.1016/0024-3205(81)90012-6.Peer-Reviewed Original ResearchConceptsFree MHPGPlasma free MHPGTourette syndromeChallenge doseNeuroendocrine responsesDoses of clonidineSingle oral dosesClonidine administrationResponsive patientsGH responseOral dosesMaintenance treatmentThyroxine indexClonidineTS patientsPatientsMHPGSyndromeT patientsNeuropsychiatric patientsPilot studyPreliminary reportMetabolic responseFurther investigationDose