2022
Systematic review of studies using platelet serotonin content to assess bioeffect of serotonin reuptake inhibitors at the serotonin transporter
Anderson G, Bruno-Pacella I. Systematic review of studies using platelet serotonin content to assess bioeffect of serotonin reuptake inhibitors at the serotonin transporter. Psychopharmacology 2022, 240: 1-13. PMID: 36399187, DOI: 10.1007/s00213-022-06276-5.Peer-Reviewed Original ResearchConceptsSerotonin reuptake inhibitorsSerotonin transporterPlatelet serotonin transporterSERT occupancyReuptake inhibitorsSystematic reviewClinical implicationsPlatelet serotonin contentMeasurement of plateletPlatelet serotonin uptakePractical clinical implicationsStudy of plateletsSerotonin uptakeHealthy controlsSerotonin contentDifferent SSRIsClinical practicePlateletsInhibitorsUptakeSNRIsSSRIsPatientsReviewTransporters
2002
Serotonin transporter promoter variants in autism: functional effects and relationship to platelet hyperserotonemia
Anderson G, Gutknecht L, Cohen DJ, Brailly-Tabard S, Cohen JH, Ferrari P, Roubertoux PL, Tordjman S. Serotonin transporter promoter variants in autism: functional effects and relationship to platelet hyperserotonemia. Molecular Psychiatry 2002, 7: 831-836. PMID: 12232775, DOI: 10.1038/sj.mp.4001099.Peer-Reviewed Original ResearchAdolescentAutistic DisorderBlood PlateletsCarrier ProteinsChildCitalopramFemaleGenetic VariationGenotypeHumansLinear ModelsMaleMembrane GlycoproteinsMembrane Transport ProteinsNerve Tissue ProteinsPromoter Regions, GeneticSelective Serotonin Reuptake InhibitorsSerotoninSerotonin Plasma Membrane Transport Proteins
1998
Peripheral serotonin measures in prepubertal psychiatric inpatients and normal children: associations with suicidal behavior and its risk factors
Pfeffer C, McBride P, Anderson G, Kakuma T, Fensterheim L, Khait V. Peripheral serotonin measures in prepubertal psychiatric inpatients and normal children: associations with suicidal behavior and its risk factors. Biological Psychiatry 1998, 44: 568-577. PMID: 9787881, DOI: 10.1016/s0006-3223(98)00020-1.Peer-Reviewed Original ResearchConceptsPrepubertal psychiatric inpatientsBlood tryptophanRisk factorsSerotonin contentSuicidal behaviorMood disordersNormal controlsInpatient childrenSuicidal ideationSerotonin-amplified platelet aggregationPsychiatric inpatientsSuicide attemptsPlatelet serotonin contentEthnic differencesRecent suicide attemptSerotonin measuresPrepubertal controlsPlatelet serotoninPrepubertal childrenInpatientsPlatelet aggregationNormal childrenWhole bloodChildrenDisordersEffects of Diagnosis, Race, and Puberty on Platelet Serotonin Levels in Autism and Mental Retardation
MCBRIDE P, ANDERSON G, HERTZIG M, SNOW M, THOMPSON S, KHAIT V, SHAPIRO T, COHEN D. Effects of Diagnosis, Race, and Puberty on Platelet Serotonin Levels in Autism and Mental Retardation. Journal Of The American Academy Of Child & Adolescent Psychiatry 1998, 37: 767-776. PMID: 9666633, DOI: 10.1097/00004583-199807000-00017.Peer-Reviewed Original ResearchSerotonin Transporter-Blocking Properties of Nefazodone Assessed by Measurement of Platelet Serotonin
Narayan M, Anderson G, Cellar J, Mallison R, Price L, Nelson J. Serotonin Transporter-Blocking Properties of Nefazodone Assessed by Measurement of Platelet Serotonin. Journal Of Clinical Psychopharmacology 1998, 18: 67-71.. PMID: 9472845, DOI: 10.1097/00004714-199802000-00011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntidepressive Agents, Second-GenerationBlood PlateletsCarrier ProteinsDepressive DisorderFemaleHumansMaleMembrane GlycoproteinsMembrane Transport ProteinsMiddle AgedNerve Tissue ProteinsPiperazinesSelective Serotonin Reuptake InhibitorsSerotoninSerotonin Plasma Membrane Transport ProteinsTriazolesConceptsSelective serotonin reuptake inhibitorsSerotonin reuptake inhibitorsHAM-D scoresHamilton Rating ScaleSerotonin type 2Nefazodone treatmentPretreatment plateletBaseline plateletSSRI treatmentReuptake inhibitorsUptake blockadeTherapeutic dosesPlatelet serotoninClinical dosesDepressed patientsMajor depressionTreatment groupsDepression scoresNefazodoneType 2Percent changeUptake inhibitionRating ScalePercent decreasePlatelets
1996
Adenosine diphosphate inhibits the serotonin transporter
Anderson G, Hall L, Horne W, Yang J. Adenosine diphosphate inhibits the serotonin transporter. Biochimica Et Biophysica Acta 1996, 1283: 14-20. PMID: 8765089, DOI: 10.1016/0005-2736(96)00073-9.Peer-Reviewed Original Research
1993
Platelet serotonin studies in hyperserotonemic relatives of children with autistic disorder
Cook E, Arora R, Anderson G, Berry-Kravis E, Yan S, Yeoh HC, Sklena P, Charak D, Leventhal B. Platelet serotonin studies in hyperserotonemic relatives of children with autistic disorder. Life Sciences 1993, 52: 2005-2015. PMID: 7684805, DOI: 10.1016/0024-3205(93)90685-v.Peer-Reviewed Original ResearchConceptsLysergic acid diethylamideParoxetine bindingWhole bloodSubgroup of subjectsHyperserotonemia of autismProstaglandin E1Arginine vasopressinDensity of plateletsCAMP productionAcid diethylamideLSD bindingAutistic disorderSignificant differencesSignificant correlationBloodSubjectsBasalSubgroupsPlateletsChildrenAutistic probandsUptake VmaxAutistic children
1992
Activators of protein kinase C decrease serotonin transport in human platelets
Anderson G, Horne W. Activators of protein kinase C decrease serotonin transport in human platelets. Biochimica Et Biophysica Acta 1992, 1137: 331-337. PMID: 1445934, DOI: 10.1016/0167-4889(92)90154-4.Peer-Reviewed Original ResearchPlatelet dense granule release reaction monitored by high-performance liquid chromatography-fluorometric determination of endogenous serotonin
Anderson G, Hall L, Yang J, Cohen D. Platelet dense granule release reaction monitored by high-performance liquid chromatography-fluorometric determination of endogenous serotonin. Analytical Biochemistry 1992, 206: 64-67. PMID: 1456443, DOI: 10.1016/s0003-2697(05)80011-9.Peer-Reviewed Original ResearchPlatelet and whole blood serotonin content in depressed inpatients: Correlations with acute and life-time psychopathology
Mann J, McBride P, Anderson G, Mieczkowski T. Platelet and whole blood serotonin content in depressed inpatients: Correlations with acute and life-time psychopathology. Biological Psychiatry 1992, 32: 243-257. PMID: 1420642, DOI: 10.1016/0006-3223(92)90106-a.Peer-Reviewed Original ResearchConceptsPlatelet serotonin contentBorderline personality disorderBlood serotonin contentSerotonin contentWhole blood serotonin contentSerotonin levelsHealthy controlsPersonality disorderLower platelet serotonin contentComorbid borderline personality disorderHigher serotonin levelsLow serotonin levelsSeverity of depressionPlatelet serotonin levelsLife-time historyBPD attemptersPatient groupMajor depressionPatientsDepressed inpatientsSuicide attemptsSuicidal behaviorNonborderline patientsWhole bloodDisordersTryptophan loading in hyperserotonemic and normoserotonemic adults
Cook E, Anderson G, Heninger G, Fletcher K, Freedman D, Leventhal B. Tryptophan loading in hyperserotonemic and normoserotonemic adults. Biological Psychiatry 1992, 31: 525-528. PMID: 1581428, DOI: 10.1016/0006-3223(92)90264-z.Peer-Reviewed Original Research
1990
The Hyperserotonemia of Autisma
ANDERSON G, HORNE W, CHATTERJEE D, COHEN D. The Hyperserotonemia of Autisma. Annals Of The New York Academy Of Sciences 1990, 600: 331-340. PMID: 2252319, DOI: 10.1111/j.1749-6632.1990.tb16893.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAutistic DisorderBlood PlateletsChildChild, PreschoolHumansInfantReference ValuesSerotoninConceptsPlatelet functionHuman platelet dense granules: Improved isolation and preliminary characterization of [3H]-serotonin uptake and tetrabenazine-displaceable [3H]-ketanserin binding
Chatterjee D, Anderson G, Chakraborty M, Cohen D. Human platelet dense granules: Improved isolation and preliminary characterization of [3H]-serotonin uptake and tetrabenazine-displaceable [3H]-ketanserin binding. Life Sciences 1990, 46: 1755-1764. PMID: 2163001, DOI: 10.1016/0024-3205(90)90139-i.Peer-Reviewed Original Research
1989
The issue of hyperserotonemia and platelet serotonin exposure: A preliminary study
Anderson G, Minderaa R, Cho S, Volkmar F, Cohen D. The issue of hyperserotonemia and platelet serotonin exposure: A preliminary study. Journal Of Autism And Developmental Disorders 1989, 19: 349-351. PMID: 2745398, DOI: 10.1007/bf02211852.Peer-Reviewed Original Research
1988
Liquid chromatographic determination of taurine in whole blood, plasma and platelets
Anderson G, Durkin T, Chakraborty M, Cohen D. Liquid chromatographic determination of taurine in whole blood, plasma and platelets. Journal Of Chromatography 1988, 431: 400-405. PMID: 3243795, DOI: 10.1016/s0378-4347(00)83109-6.Peer-Reviewed Original Research
1987
WHOLE BLOOD SEROTONIN IN AUTISTIC AND NORMAL SUBJECTS
Anderson G, Freedman D, Cohen D, Volkmar F, Hoder E, McPhedran P, Minderaa R, Hansen C, Young J. WHOLE BLOOD SEROTONIN IN AUTISTIC AND NORMAL SUBJECTS. Journal Of Child Psychology And Psychiatry 1987, 28: 885-900. PMID: 3436995, DOI: 10.1111/j.1469-7610.1987.tb00677.x.Peer-Reviewed Original ResearchConceptsWhole blood serotoninSerotonin levelsBlood serotoninNormal subjectsWhole blood serotonin concentrationAutistic subjectsBlood serotonin concentrationsBlood tryptophan levelsLow serotonin levelsHyperserotonemia of autismPlatelet countSerotonin concentrationsNormal groupTryptophan levelsSerotoninAutistic groupSubjectsPossible causesAnticonvulsantsNeurolepticsGroupLevelsHyperserotonemiaSteady-state model for plasma free and platelet serotonin in man
Anderson G, Stevenson J, Cohen D. Steady-state model for plasma free and platelet serotonin in man. Life Sciences 1987, 41: 1777-1785. PMID: 3657383, DOI: 10.1016/0024-3205(87)90696-5.Peer-Reviewed Original ResearchDetermination of serotonin in whole blood, platelet-rich plasma, platelet-poor plasma and plasma ultrafiltrate
Anderson G, Feibel F, Cohen D. Determination of serotonin in whole blood, platelet-rich plasma, platelet-poor plasma and plasma ultrafiltrate. Life Sciences 1987, 40: 1063-1070. PMID: 3821372, DOI: 10.1016/0024-3205(87)90568-6.Peer-Reviewed Original Research
1984
Platelet imipramine binding in autistic subjects
Anderson G, Minderaa R, van Benthem P, Volkmar F, Cohen D. Platelet imipramine binding in autistic subjects. Psychiatry Research 1984, 11: 133-141. PMID: 6584936, DOI: 10.1016/0165-1781(84)90097-0.Peer-Reviewed Original Research
1982
Clinical neurochemistry of autism and associated disorders
Young J, Kavanagh M, Anderson G, Shaywitz B, Cohen D. Clinical neurochemistry of autism and associated disorders. Journal Of Autism And Developmental Disorders 1982, 12: 147-165. PMID: 6184361, DOI: 10.1007/bf01531305.Peer-Reviewed Original ResearchConceptsNorepinephrine metabolismNeurochemical methodsClinical neurochemistryClinical studiesNeurochemical studiesBehavioral deficitsBiochemical dysfunctionBrain functionAutistic syndromeInfantile autismLow levelsNew studiesAutismDysfunctionSerotoninSyndromeAutistic individualsSymptomsNeurochemistryBrainMajor obstacle