2006
Effects of Short- and Long-Term Risperidone Treatment on Prolactin Levels in Children with Autism
Anderson GM, Scahill L, McCracken JT, McDougle CJ, Aman MG, Tierney E, Arnold LE, Martin A, Katsovich L, Posey DJ, Shah B, Vitiello B. Effects of Short- and Long-Term Risperidone Treatment on Prolactin Levels in Children with Autism. Biological Psychiatry 2006, 61: 545-550. PMID: 16730335, DOI: 10.1016/j.biopsych.2006.02.032.Peer-Reviewed Original ResearchConceptsRisperidone-induced increasesLong-term risperidone treatmentProlactin levelsRisperidone treatmentSerum prolactinOpen-label followWeeks of risperidoneBaseline prolactin levelsEffects of ShortPlacebo groupProlactin elevationReceptor polymorphismsWeek 8Baseline levelsMean increaseProlactinRisperidoneSerum samplesAdverse effectsPlaceboChildrenTreatmentMonthsDRD2 allelesAdolescents
1991
Emergence of Self-Destructive Phenomena in Children and Adolescents during Fluoxetine Treatment
KING R, RIDDLE M, CHAPPELL P, HARDIN M, ANDERSON G, LOMBROSO P, SCAHILL L. Emergence of Self-Destructive Phenomena in Children and Adolescents during Fluoxetine Treatment. Journal Of The American Academy Of Child & Adolescent Psychiatry 1991, 30: 179-186. PMID: 2016219, DOI: 10.1097/00004583-199103000-00003.Peer-Reviewed Original ResearchConceptsFluoxetine treatmentObsessive-compulsive disorderUniversity Clinical Research CenterClinical Research CenterMajor risk factorDrug-induced activationPrior suicidal ideationYounger patientsRisk factorsRegulation of aggressionPatientsSuicidal ideationSelf-destructive behaviorFluoxetineAge 10Apparent associationVulnerable individualsDisordersTreatmentIdeationDe novoHospitalizationSymptoms
1986
Cerebrospinal fluid monoamine precursor and metabolite levels in children treated for leukemia: Age and sex effects and individual variability
Riddle M, Anderson G, McIntosh S, Harcherik D, Shaywitz B, Cohen D. Cerebrospinal fluid monoamine precursor and metabolite levels in children treated for leukemia: Age and sex effects and individual variability. Biological Psychiatry 1986, 21: 69-83. PMID: 2417634, DOI: 10.1016/0006-3223(86)90009-0.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaMetabolite homovanillic acidHomovanillic acidMonoamine precursorsCerebrospinal fluidLevels of HVALumbar cerebrospinal fluidCNS traumaCSF levelsLymphoblastic leukemiaMonoamine systemsCSF samplesChronic effectsSignificant sex differencesMetabolite levelsSignificant correlationLeukemiaSex differencesChildrenIndividual variabilityAgeSex effectsTreatmentLevelsMean coefficient
1984
Whole blood serotonin and tryptophan levels in Tourette's disorder: Effects of acute and chronic clonidine treatment
Leckman J, Anderson G, Cohen D, Ort S, Harcherik D, Hoder E, Shaywitz B. Whole blood serotonin and tryptophan levels in Tourette's disorder: Effects of acute and chronic clonidine treatment. Life Sciences 1984, 35: 2497-2503. PMID: 6595491, DOI: 10.1016/0024-3205(84)90435-1.Peer-Reviewed Original ResearchConceptsChronic clonidine treatmentClonidine treatmentTourette's disorder patientsWhole blood serotoninDisorder patientsTourette's disorderBlood serotoninTryptophan levelsMean differenceChronic treatmentAcute doseNormal controlsMean increaseClonidinePatientsDisordersMode of actionTreatmentSignificant differencesSerotoninBaseline conditionsLevelsDifferencesDoseSympathetic control of sexual reflexes: Peripheral 6-hydroxydopamine administration facilitates the onset of penile reflexes in male rats
Howard S, Lumia A, Anderson G, Shaywitz B. Sympathetic control of sexual reflexes: Peripheral 6-hydroxydopamine administration facilitates the onset of penile reflexes in male rats. Physiology & Behavior 1984, 32: 791-794. PMID: 6436843, DOI: 10.1016/0031-9384(84)90196-3.Peer-Reviewed Original ResearchConceptsControl subjectsPenile reflexesMale ratsPeripheral norepinephrine levelsSympathetic inhibitionChemical sympathectomyNorepinephrine levelsSympathetic controlSexual reflexesReflexRatsMean numberSignificant differencesFirst reflexAdministrationOne daySubjectsSalineDaysTreatmentOnsetSympathectomy