2000
Imaging extrastriatal dopamine D2 receptor occupancy by endogenous dopamine in healthy humans
Fujita M, Verhoeff N, Varrone A, Zoghbi S, Baldwin R, Jatlow P, Anderson G, Seibyl J, Innis R. Imaging extrastriatal dopamine D2 receptor occupancy by endogenous dopamine in healthy humans. European Journal Of Pharmacology 2000, 387: 179-188. PMID: 10650158, DOI: 10.1016/s0014-2999(99)00817-1.Peer-Reviewed Original ResearchConceptsAcute dopamine depletionDopamine depletionEndogenous dopamineAlpha-methylTemporal cortexExtrastriatal dopamine D2 receptor occupancyDopamine D2 receptor occupancyD2 receptor occupancySynaptic dopamine concentrationsSingle photon emissionNegative Symptom ScalePara-tyrosineExtrastriatal regionsOral administrationHealthy humansSymptom ScaleReceptor occupancyDopamine concentrationsDysphoric moodDopaminePhoton emissionHigh-affinity ligandsCortexVivo measurementsThalamus
1994
Aspartame, behavior, and cognitive function in children with attention deficit disorder.
Shaywitz B, Sullivan C, Anderson G, Gillespie S, Sullivan B, Shaywitz S. Aspartame, behavior, and cognitive function in children with attention deficit disorder. Pediatrics 1994, 93: 70-5. PMID: 7505423, DOI: 10.1542/peds.93.1.70.Peer-Reviewed Original ResearchConceptsAttention deficit disorderWisconsin Card Sorting TestDeficit disorderTreatment Emergent Symptom ScalePlacebo-controlled crossover studyComplete blood cell countStudy centersLiver function testsUrinary excretion rateBlood cell countAdministration of aspartameMental Disorders criteriaCognitive testsMeasurement of catecholaminesCrossover studyFunction testsMonoamine metabolismInpatient admissionsMetabolite excretionLarge dosesSymptom ScaleUsual consumptionCell countPlasma phenylalanineBiochemical measures