1983
Dopaminergic but not noradrenergic mediation of hyperactivity and performance deficits in the developing rat pup
Shaywitz B, Teicher M, Cohen D, Anderson G, Young J, Levitt P. Dopaminergic but not noradrenergic mediation of hyperactivity and performance deficits in the developing rat pup. Psychopharmacology 1983, 82: 73-77. PMID: 6420833, DOI: 10.1007/bf00426384.Peer-Reviewed Original ResearchConceptsRat pupsDays of ageMotor activityBehavioral arousalPostsynaptic dopaminergic mechanismsReduction of norepinephrineReduction of dopamineGeneral motor activityMesolimbic dopaminergic pathwayDopaminergic mechanismsBrain dopaminePreferential reductionEscape latencyNoradrenergic mediationNorepinephrinePostnatal lifeWeek 3PupsSuch treatmentDopamineT-mazeShuttle boxAgeDesmethylimipraminePerformance deficits
1982
Psychopharmacology of attention deficit disorder: pharmacokinetic, neuroendocrine, and behavioral measures following acute and chronic treatment with methylphenidate.
Shaywitz S, Hunt R, Jatlow P, Cohen D, Young J, Pierce R, Anderson G, Shaywitz B. Psychopharmacology of attention deficit disorder: pharmacokinetic, neuroendocrine, and behavioral measures following acute and chronic treatment with methylphenidate. Pediatrics 1982, 69: 688-94. PMID: 7079034, DOI: 10.1542/peds.69.6.688.Peer-Reviewed Original ResearchConceptsAcute studyMPH concentrationsGrowth hormoneObserved maximal concentrationCentral dopaminergic mechanismsPeak plasma concentrationAdministration of medicationsPharmacokinetics of methylphenidatePlasma growth hormoneConcentrations of methylphenidatePlasma MPH concentrationsAttention deficit disorderClinical responseChronic treatmentDopaminergic mechanismsGroup of childrenDisorders of attentionAbbreviated Conners' Rating ScaleSchool-aged childrenOral administrationPlasma concentrationsClinical pharmacologyMPH administrationProlactin concentrationsPercentage of improvement
1981
Effects of bromocriptine in developing rat pups after 6-hydroxydopamine
Shaywitz B, Lipton S, Teicher M, Cohen D, Anderson G, Batter D, Young J. Effects of bromocriptine in developing rat pups after 6-hydroxydopamine. Pharmacology Biochemistry And Behavior 1981, 15: 443-448. PMID: 6794039, DOI: 10.1016/0091-3057(81)90275-6.Peer-Reviewed Original ResearchConceptsVehicle pupsHigh dosesDays of ageRat pupsCombination of desmethylimipramineInhibitory dopaminergic mechanismDoses of bromocriptineEffects of bromocriptineLittle clinical utilityGeneral motor activityAttention deficit disorderHole boxVehicle animalsDenervation supersensitivityDopaminergic mechanismsBrain dopamineClinical syndromeCommon disorderBromocriptineClinical utilityLonger observation periodPharmacological agentsPostnatal lifeMotor activityFirst month