2011
Chloride Regulation of Enzyme Turnover: Application to the Role of Chloride in Photosystem II
Pokhrel R, McConnell IL, Brudvig GW. Chloride Regulation of Enzyme Turnover: Application to the Role of Chloride in Photosystem II. Biochemistry 2011, 50: 2725-2734. PMID: 21366335, DOI: 10.1021/bi2000388.Peer-Reviewed Original ResearchConceptsOxygen-evolving complexPhotosystem IICatalytic residuesChloride-binding siteRecent structural evidenceCyanobacterial photosystem IISalt bridgeEnzyme-substrate complexΑ-amylaseResidue crucialConformational shiftS-state cycleLys residuesCarboxylate residuesEnzyme turnoverChloride regulationResiduesD61Structural evidenceManganese clusterEnzymeBindingD1Potential mechanismsArg
2005
Catalytic Oxygen Evolution by a Bioinorganic Model of the Photosystem II Oxygen-Evolving Complex
Howard D, Tinoco A, Brudvig G, Vrettos J, Allen B. Catalytic Oxygen Evolution by a Bioinorganic Model of the Photosystem II Oxygen-Evolving Complex. Journal Of Chemical Education 2005, 82: 791. DOI: 10.1021/ed082p791.Peer-Reviewed Original ResearchBioinorganic modelsWater oxidationMn4 clusterArtificial water oxidation catalystsBioinorganic model complexesCatalytic oxygen evolutionWater oxidation catalystsPhotosystem IIPhotosynthetic water oxidationUV-visible spectroscopyOxygen-Evolving ComplexDeuterium kinetic isotope effectsPhotosystem II Oxygen Evolving ComplexKinetic isotope effectsBioinorganic chemistryTerpy complexesInorganic synthesisPlace of H2OManganese complexesModel complexesPrimary oxidantManganese clusterOne-electronOxygen evolutionActive site
2004
Investigation of the Functional Role of Ca2+ in the Oxygen‐Evolving Complex of Photosystem II: A pH‐Dependence Study of the Substitution of Ca2+ by Sr2+
Lee C, Brudvig G. Investigation of the Functional Role of Ca2+ in the Oxygen‐Evolving Complex of Photosystem II: A pH‐Dependence Study of the Substitution of Ca2+ by Sr2+. Journal Of The Chinese Chemical Society 2004, 51: 1221-1228. DOI: 10.1002/jccs.200400178.Peer-Reviewed Original ResearchOxygen-evolving complexOxygen evolution activityPhotosystem IISr 2Water oxidation chemistryOxidation of waterPH dependenceMetal ions resultsTetranuclear manganese clusterElectron acceptor sidePH dependence studyOxidation chemistryWater oxidationManganese clusterLewis acidOxygen-evolving activityOxygen evolutionEssential acidic groupAcidic groupsSubstitution of Ca2Ions resultsOnly ionsCatalytic siteCa 2Chloride ions
2002
Water oxidation chemistry of photosystem II
Vrettos J, Brudvig G. Water oxidation chemistry of photosystem II. Philosophical Transactions Of The Royal Society B Biological Sciences 2002, 357: 1395-1405. PMID: 12437878, PMCID: PMC1693042, DOI: 10.1098/rstb.2002.1136.Peer-Reviewed Original ResearchConceptsManganese clusterProton-coupled electron transfer stepsO bond-forming stepPhotosystem IIWater oxidation chemistryBond-forming stepElectron transfer stepFour-electron oxidationTetranuclear manganese clusterOxidation chemistryWater moleculesModel chemistryO bondNucleophilic attackIon selectivityBiophysical studiesChemistryCalcium sitesOxidationSpecific roleModel systemComplexesHis190Recent studiesWater
2001
Mechanism of photosynthetic water oxidation: combining biophysical studies of photosystem II with inorganic model chemistry
Vrettos J, Limburg J, Brudvig G. Mechanism of photosynthetic water oxidation: combining biophysical studies of photosystem II with inorganic model chemistry. Biochimica Et Biophysica Acta 2001, 1503: 229-245. PMID: 11115636, DOI: 10.1016/s0005-2728(00)00214-0.Peer-Reviewed Original ResearchMeSH KeywordsCrystallographyElectron TransportHemerythrinHydrogen-Ion ConcentrationKineticsManganeseModels, ChemicalModels, MolecularOrganometallic CompoundsOxidation-ReductionOxygenPhotosynthesisPhotosynthetic Reaction Center Complex ProteinsPhotosystem II Protein ComplexProtonsThylakoidsTyrosineWaterConceptsPhotosynthetic water oxidationWater oxidationOxygen-evolving complexProton-coupled electron transferTetranuclear manganese clusterMu-oxo bridgePhotosystem IIReduction of manganeseOOH speciesWater moleculesElectron transferModel chemistryManganese clusterNucleophilic attackDiferric siteFerric hydroperoxideOxidationD1 polypeptideBiophysical studiesOxyhemerythrinBiophysical resultsStructural modelDioxygenChemistryProtonation