2019
FURIN variant associations with postexercise hypotension are intensity and race dependent
Cilhoroz BT, Schifano ED, Panza GA, Ash GI, Corso L, Chen M, Deshpande V, Zaleski A, Farinatti P, Santos LP, Taylor BA, O'Neill RJ, Thompson PD, Pescatello LS. FURIN variant associations with postexercise hypotension are intensity and race dependent. Physiological Reports 2019, 7: e13952. PMID: 30706700, PMCID: PMC6356167, DOI: 10.14814/phy2.13952.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBicyclingBlack or African AmericanBlood PressureCase-Control StudiesExerciseFemaleFurinGenetic Association StudiesGenetic Predisposition to DiseaseHumansHypertensionHypotensionMaleMiddle AgedObesityPhenotypePolymorphism, Single NucleotideRisk FactorsTime FactorsWhite PeopleYoung AdultConceptsPostexercise hypotensionSystolic BPDiastolic BPBlood pressure responseAmbulatory BP monitorBlood pressure regulationModerate-intensity cyclingRace-dependent associationsObese blacksAerobic exerciseBP measurementsBP monitorIntensity cyclingAwake hoursMmHgPressure regulationMinor alleleMerit further explorationPressure responseHypotensionHypertensionP-valueReceptor processingMultiple testing
2016
Deep‐targeted exon sequencing reveals renal polymorphisms associate with postexercise hypotension among African Americans
Pescatello LS, Schifano ED, Ash GI, Panza GA, Lamberti L, Chen M, Deshpande V, Zaleski A, Farinatti P, Taylor BA, Thompson PD. Deep‐targeted exon sequencing reveals renal polymorphisms associate with postexercise hypotension among African Americans. Physiological Reports 2016, 4: e12992. PMID: 27940662, PMCID: PMC5064144, DOI: 10.14814/phy2.12992.Peer-Reviewed Original ResearchConceptsMultiple testing thresholdADD1 variantsAngiotensin type 1 receptorAmbulatory blood pressure responsesTesting thresholdBlood pressure responseExon sequencingAmbulatory BP monitorModerate-intensity exerciseType 1 receptorModerate-intensity cyclingPostexercise hypotensionRenal variantDiastolic BPAcute exerciseValidation cohortBP measurementsBP monitorIntensity exerciseVigorous intensityAdducin geneVariant genotypesAldosterone synthaseIntensity cyclingCYP11B2 variants