2002
Applying Hidden Markov Models to the Analysis of Single Ion Channel Activity
Venkataramanan L, Sigworth F. Applying Hidden Markov Models to the Analysis of Single Ion Channel Activity. Biophysical Journal 2002, 82: 1930-1942. PMID: 11916851, PMCID: PMC1301989, DOI: 10.1016/s0006-3495(02)75542-2.Peer-Reviewed Original ResearchConceptsCorrelated background noiseHidden Markov ModelDigital inverse filterMarkov model parametersDiscrete timeBaum-Welch algorithmMarkov modelComputational intensityDeterministic interferenceModel parametersInverse filterMultiple data setsAlgorithmPrevious resultsPractical applicationsNoise ratioState transitionsSharp frequencyData setsChannel dataSingle ion channel currentsNoiseExtensionRandomnessBackground noise
1999
Two-Microelectrode Voltage Clamp of Xenopus Oocytes: Voltage Errors and Compensation for Local Current Flow
Baumgartner W, Islas L, Sigworth F. Two-Microelectrode Voltage Clamp of Xenopus Oocytes: Voltage Errors and Compensation for Local Current Flow. Biophysical Journal 1999, 77: 1980-1991. PMID: 10512818, PMCID: PMC1300479, DOI: 10.1016/s0006-3495(99)77039-6.Peer-Reviewed Original Research
1990
Yet another approach to the dwell-time omission problem of single-channel analysis
Crouzy S, Sigworth F. Yet another approach to the dwell-time omission problem of single-channel analysis. Biophysical Journal 1990, 58: 731-743. PMID: 1698473, PMCID: PMC1281014, DOI: 10.1016/s0006-3495(90)82416-4.Peer-Reviewed Original Research
1987
Data transformations for improved display and fitting of single-channel dwell time histograms
Sigworth F, Sine S. Data transformations for improved display and fitting of single-channel dwell time histograms. Biophysical Journal 1987, 52: 1047-1054. PMID: 2447968, PMCID: PMC1330104, DOI: 10.1016/s0006-3495(87)83298-8.Peer-Reviewed Original Research
1981
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
Hamill O, Marty A, Neher E, Sakmann B, Sigworth F. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Archiv - European Journal Of Physiology 1981, 391: 85-100. PMID: 6270629, DOI: 10.1007/bf00656997.Peer-Reviewed Original Research