1999
Gramicidin channel controversy — the structure in a lipid environment
Andersen O, Apell H, Bamberg E, Busath D, Koeppe R, Sigworth F, Szabo G, Urry D, Woolley A. Gramicidin channel controversy — the structure in a lipid environment. Nature Structural & Molecular Biology 1999, 6: 609-609. PMID: 10404209, DOI: 10.1038/10648.Peer-Reviewed Original Research
1993
Substitution of a hydrophobic residue alters the conformational stability of Shaker K+ channels during gating and assembly
McCormack K, Lin L, Sigworth F. Substitution of a hydrophobic residue alters the conformational stability of Shaker K+ channels during gating and assembly. Biophysical Journal 1993, 65: 1740-1748. PMID: 8274662, PMCID: PMC1225901, DOI: 10.1016/s0006-3495(93)81202-5.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBiophysical PhenomenaBiophysicsDNA, ComplementaryDrosophilaDrug StabilityFemaleIon Channel GatingMembrane PotentialsMolecular Sequence DataMutagenesis, Site-DirectedOocytesPeptidesPotassium ChannelsProtein ConformationShaker Superfamily of Potassium ChannelsThermodynamicsXenopus laevisConceptsUncharged amino acid residuesLeucine heptad repeatWild-type subunitsPosition 370Large hydrophobic residuesAmino acid residuesSequence motifsConservative substitutionsHeptad repeatHydrophobic residuesVoltage-gated channelsLeucine residuesAcid residuesTertiary structureS4 segmentSpecific hydrophobic interactionsHydrophilic residuesResidue altersChannel subunitsInactivation gatingChannel complexSubunitsConformational stabilityConformational transitionResidues
1989
Transmembrane Channels Based on Tartaric Acid-Gramicidin A Hybrids
Stankovic C, Heinemann S, Delfino J, Sigworth F, Schreiber S. Transmembrane Channels Based on Tartaric Acid-Gramicidin A Hybrids. Science 1989, 244: 813-817. PMID: 2471263, DOI: 10.1126/science.2471263.Peer-Reviewed Original Research